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Effect of endothelıum on the repetıtıve concentratıon response curves to norepınephrıne ın rabbıt aorta

Year 1988, Volume: 1 Issue: 1 - Marmara Medical Journal, 13 - 15, 01.01.1988

Ş. Oktay

Abstract

Endothelial cells release a relaxant factor, endothe- lum derived relaxing factor (EDRF), and mediate relaxation of vascular smooth muscle induced by various agonists. On the other hand, removal of endothelium potentiates vasoconstrictor effect of norepinephrine (NE). In the present study, it is shown that removal of the endothelium of isolated rabbit thoracic aortic strips, causes a significant increase in the slopes of the concentration-response curves to NE obtained repetitively after the control curve. An earlier desensitization was observed in rubbed preparations when compared with unrubbed strips. These findings suggest that removal of endothelium alters the characteristics of the concentration-response curves to NE and this may cause wrong interpretations if endothelium was not kept intact.

Keywords

Rabbit thoracic aorta; Norepinephrine; Endothelium.

Year 1988, Volume: 1 Issue: 1 - Marmara Medical Journal, 13 - 15, 01.01.1988

Ş. Oktay

Abstract

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Details

Subjects Clinical Sciences
Journal Section Articles
Authors

Ş. Oktay This is me

Publication Date January 1, 1988
Published in Issue Year 1988 Volume: 1 Issue: 1 - Marmara Medical Journal

Cite

APA Oktay, Ş. (1988). Effect of endothelıum on the repetıtıve concentratıon response curves to norepınephrıne ın rabbıt aorta. Marmara Medical Journal, 1(1), 13-15.
AMA Oktay Ş. Effect of endothelıum on the repetıtıve concentratıon response curves to norepınephrıne ın rabbıt aorta. Marmara Med J. January 1988;1(1):13-15.
Chicago Oktay, Ş. “Effect of endothelıum on the repetıtıve concentratıon Response Curves to norepınephrıne ın rabbıt Aorta”. Marmara Medical Journal 1, no. 1 (January 1988): 13-15.
EndNote Oktay Ş (January 1, 1988) Effect of endothelıum on the repetıtıve concentratıon response curves to norepınephrıne ın rabbıt aorta. Marmara Medical Journal 1 1 13–15.
IEEE Ş. Oktay, “Effect of endothelıum on the repetıtıve concentratıon response curves to norepınephrıne ın rabbıt aorta”, Marmara Med J, vol. 1, no. 1, pp. 13–15, 1988.
ISNAD Oktay, Ş. “Effect of endothelıum on the repetıtıve concentratıon Response Curves to norepınephrıne ın rabbıt Aorta”. Marmara Medical Journal 1/1 (January 1988), 13-15.
JAMA Oktay Ş. Effect of endothelıum on the repetıtıve concentratıon response curves to norepınephrıne ın rabbıt aorta. Marmara Med J. 1988;1:13–15.
MLA Oktay, Ş. “Effect of endothelıum on the repetıtıve concentratıon Response Curves to norepınephrıne ın rabbıt Aorta”. Marmara Medical Journal, vol. 1, no. 1, 1988, pp. 13-15.
Vancouver Oktay Ş. Effect of endothelıum on the repetıtıve concentratıon response curves to norepınephrıne ın rabbıt aorta. Marmara Med J. 1988;1(1):13-5.