Yıl 1999, Cilt 12 , Sayı 3, Sayfalar 134 - 137 2016-12-03

Objective: In this experiment, supplementation of the diet with increased levels of glutamine was used to determine glutamine enriched diet effect on the healing of ileal anastomosis.
Methods: Forty albino Wistar rats, in four groups, had a special diet 7 days prior to surgery and 7 days after surgery. On the 7th day of study a complete cut of the ileal wall was carried out and an anastomosis was performed using single layer interrupted inverting sutures. Group 1 received a normal diet for all 14 days; group 2 received a glutamine enriched diet 7 days prior to surgery and a normal diet 7 days after surgery; group 3 received a normal diet prior to surgery and a glutamine enriched diet after surgery; group 4 received a constant glutamine enriched diet. On the 7th postoperative day, tensile strength measurements and hydroxyproline level analyses were done.
Results: A preoperative glutamine enriched diet did not show any significant improvement in the bursting pressure and hydroxyproline levels on the 7th postoperative day, but pre and postoperative, and postoperative glutamine enriched diet significantly improved when compared with the normal diet group (p<0.05).
Conclusion: These findings show that when a glutamine enriched diet was used, in the postoperative or both pre and postoperative period, hydroxyproline levels and bursting pressures increased, indicating a good anastomotic healing.
Key Words: Anastomotic healing, Glutamine, Bursting pressure

  • /. Jorge EA. nutrition and wound healing. JPEh 1994;18:367-376.
  • tlall JC, tleel K, McCauley R. Glutamine. Br J Surg 1996;83:305-312.
  • Zielke RH, Ozand PT, Tildon JT, Sevdalian DA, Cornblath n. Reciprocal regulation oi glucose and glutamine utilization by cultured human diploid fibroblasts. J Cell Physiol 1978;95:41-48.
  • Hendriks T, Walter JB, Mast boom B. healing of experimental intestinal anastomoses. Dis Colon Rectum 1990;33:891-901.
  • Aszodi A; Ponsky JL. Effects of 5-fluorouracil on the healing of bowel anastomosis in rats. Am Surgeon 1985;51:671-674.
  • WeesnerJP. The determination of hydroxyproline in tissue and protein samples containing small proportions of this aminoacid. Arch Biochemistry Biophysics 1961 ,-93:440-447.
  • Madden JW, Peacock EE Jr. Studies on the biology of collagen during wound healing 1. Rate of collagen synthesis and deposition in cutaneous wound in rat. Surgery 1968;64:288-294.
  • Bernstein EF, Salomon GD, Hahsiaidis L, et at. Collagen gene expression and wound strength in normal and radiation-impaired wounds. Dermatol Surg Oncol 1993;19:564-570.
  • hangkomp LJ, henken B, Suziki R, Stahlaren LE. Glutamine presents parenteral nutrition induced increases in intestinal permeability. JPEh 1994;18:303-307.
  • Coldwell MD. Local glutamine metabolism in wounds and inflammation. Metabolism 1989:38:34-
  • Yavuzer R, Taşçılar Ö, Tekin E, et al. Incisional healing in rats treated with diethyl maleate. Eur J Plast Surg 1997;20:306-309.
  • Chen R, Okamura K, Targoe Y, Miyauchi Y. Glutamine supplemental parenteral nutrition improves gut mucosa integrity and function in endotoxemic rats. JPEh 1994; 18:167-1 71.
  • Windmueller HG, Spaeth AE. Course and rate of circulating citrulline. Am J Physiol 1981;241 :E473- 480.
  • Kirk SJ, BarbuI A. Role of arginine in trauma, sepsis, and immunity. JPEH 1990; 14(suppl):226-229.
  • hong RW, Rounds JD, helton W'S, Robinson MK, Wilmore DW. Glutamine preserves liver glutathione after lethal hepatic injury. Ann Surg 1992, 215:1 14- I 19.
  • Mc Cauley K, Platell C, hall J, Mc Culjoch R. Effects of glutamine infusion on colonic anastomotic strenght in the rat. JPEh 1991;15:437-439.
  • I 7. Ashy AA, Ardawi SM. Glucose, glutamine and keton body metabolism in human entorocytes. Metabolism 1986;37:602-609.
  • Klimberg US, Souba WW, Dolson DJ, et al. Prophylactic glutamine protects the intestinal mucosa from radiation injury. Cancer 1990:66:62- 68.
  • Platell C, Me Cauley K, Mc Culloch R, Hill R. The influence of parenteral glutamine and branched- chain aminoacids on total parenteral nutrition induced atrophy of the gut. JPEh 1993; I 7:348-354.
  • ODywer ST, Smith RT, Hwang TC. Maintenance of small bowel mucosa with glutamine enriched parenteral nutrition. JPEh 1989; 13:579-585.
  • !. Jacops DO, Evans A, ODywer ST. Disparité effects of 5-fluorauracil on the ileum and colon of enterally fed rats with protection of dietery glutamine. Surg Forum 1987;38:45-49.
  • Fox AD, Kripkes A, De Pauloj F. Effect of a glutamine supplemented diet on methotraxate induced enterocolitis. JPEh 1988; 19:325-331.
  • Klimberg US, Sallaum RM, Kapser M, et al. Oral glutamine accelerates healing of small intestine and improves outcome after whole abdominal radiation. Arch Surg 1990; 125:1040-1045.
  • ORiordin MG, Fearon KCH, Ross JA, et al. Glutamine supplemented total parenteral nutrition enhances T lymphocyte response in surgical patients undergoing colorectal resection. Ann Surg 1994;220:212-221.
  • Chen K, Okuma T, Okamura K, Tangoe Y, Miyauchi Y. Glutamine supplemented parenteral nutrition improves gut mucosal integrity and function in endotoxemic rats. JPEh 1994; 18:167-1 71.
Bölüm Original Research
Yazarlar

Yazar: Ferit TANERİ

Yazar: Ercüment TEKİN

Yazar: Emin ERSOY

Yazar: Eser ÖZ

Yazar: İshak TEKİN

Yazar: Mehmet OĞUZ

Yazar: Erhan ONUK

Tarihler

Yayımlanma Tarihi : 3 Aralık 2016

Bibtex @ { marumj271958, journal = {Marmara Medical Journal}, issn = {1019-1941}, eissn = {1309-9469}, address = {}, publisher = {Marmara Üniversitesi}, year = {2016}, volume = {12}, pages = {134 - 137}, doi = {}, title = {THE EFFECTS OF GLUTAMINE-ENRICHED FEEDING ON ILEAL ANASTOMOSE HEALING IN RATS}, key = {cite}, author = {TANERİ, Ferit and TEKİN, Ercüment and ERSOY, Emin and ÖZ, Eser and TEKİN, İshak and OĞUZ, Mehmet and ONUK, Erhan} }
APA TANERİ, F , TEKİN, E , ERSOY, E , ÖZ, E , TEKİN, İ , OĞUZ, M , ONUK, E . (2016). THE EFFECTS OF GLUTAMINE-ENRICHED FEEDING ON ILEAL ANASTOMOSE HEALING IN RATS. Marmara Medical Journal , 12 (3) , 134-137 . Retrieved from https://dergipark.org.tr/tr/pub/marumj/issue/25787/271958
MLA TANERİ, F , TEKİN, E , ERSOY, E , ÖZ, E , TEKİN, İ , OĞUZ, M , ONUK, E . "THE EFFECTS OF GLUTAMINE-ENRICHED FEEDING ON ILEAL ANASTOMOSE HEALING IN RATS". Marmara Medical Journal 12 (2016 ): 134-137 <https://dergipark.org.tr/tr/pub/marumj/issue/25787/271958>
Chicago TANERİ, F , TEKİN, E , ERSOY, E , ÖZ, E , TEKİN, İ , OĞUZ, M , ONUK, E . "THE EFFECTS OF GLUTAMINE-ENRICHED FEEDING ON ILEAL ANASTOMOSE HEALING IN RATS". Marmara Medical Journal 12 (2016 ): 134-137
RIS TY - JOUR T1 - THE EFFECTS OF GLUTAMINE-ENRICHED FEEDING ON ILEAL ANASTOMOSE HEALING IN RATS AU - Ferit TANERİ , Ercüment TEKİN , Emin ERSOY , Eser ÖZ , İshak TEKİN , Mehmet OĞUZ , Erhan ONUK Y1 - 2016 PY - 2016 N1 - DO - T2 - Marmara Medical Journal JF - Journal JO - JOR SP - 134 EP - 137 VL - 12 IS - 3 SN - 1019-1941-1309-9469 M3 - UR - Y2 - 2020 ER -
EndNote %0 Marmara Medical Journal THE EFFECTS OF GLUTAMINE-ENRICHED FEEDING ON ILEAL ANASTOMOSE HEALING IN RATS %A Ferit TANERİ , Ercüment TEKİN , Emin ERSOY , Eser ÖZ , İshak TEKİN , Mehmet OĞUZ , Erhan ONUK %T THE EFFECTS OF GLUTAMINE-ENRICHED FEEDING ON ILEAL ANASTOMOSE HEALING IN RATS %D 2016 %J Marmara Medical Journal %P 1019-1941-1309-9469 %V 12 %N 3 %R %U
ISNAD TANERİ, Ferit , TEKİN, Ercüment , ERSOY, Emin , ÖZ, Eser , TEKİN, İshak , OĞUZ, Mehmet , ONUK, Erhan . "THE EFFECTS OF GLUTAMINE-ENRICHED FEEDING ON ILEAL ANASTOMOSE HEALING IN RATS". Marmara Medical Journal 12 / 3 (Aralık 2016): 134-137 .
AMA TANERİ F , TEKİN E , ERSOY E , ÖZ E , TEKİN İ , OĞUZ M , ONUK E . THE EFFECTS OF GLUTAMINE-ENRICHED FEEDING ON ILEAL ANASTOMOSE HEALING IN RATS. Marmara Med J. 2016; 12(3): 134-137.
Vancouver TANERİ F , TEKİN E , ERSOY E , ÖZ E , TEKİN İ , OĞUZ M , ONUK E . THE EFFECTS OF GLUTAMINE-ENRICHED FEEDING ON ILEAL ANASTOMOSE HEALING IN RATS. Marmara Medical Journal. 2016; 12(3): 137-134.