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CARDIAC AMYLOIDOSIS AS A COMPLICATION OF MULTIPLE MYELOMA

Year 1999, Volume: 12 Issue: 2, 94 - 97, 03.12.2016

Sibel Ersan Refik Demirtunç Yıldırım Çınar

Abstract

Restrictive cardiomyopathy due to cardiac amyloid deposition is not an uncommon complication of multiple myeloma. Most cases of cardiac amyloidosis reported in early series were diagnosed postmortem at autopsy(1,2).
The following is a report of a case with antemortem diagnosis of cardiac amyloidosis as a complication of multiple myeloma. We described the clinical features and diagnostic approaches by review of the literature.
Key Words : Cardiac amyloidosis, Multiple myeloma, Restrictive cardiomyopathy

References

  • O'Connell JB, Renland DO. Myocarditis and specific myocardial diseases. In: Schlant RC, Alexander RW, O'Rourke RA, et al (eds). Hurst's The Heart, 8^’ ed. Hew York, McGraw-Hill, 1994:1591 -1607.
  • Dubrey SIV, Cha R, Anderson J, et at. The clinical features of immunoglobulin light-chain (AL) amyloidosis with heart involvement (abstract). QJM 1998;91:141-157.
  • 6
  • Marmara Medical Journal Volume 12 No 2 April 1999
  • Vaitkus PT, Kussmaul WG. Constrictive pericarditis versus restrictive cardiomyopathy: a reappraisal and update of diagnostic criteria. Am Heart J 1991;122:1431-1441.
  • Hamer JP, Janssen S, Rijswijk van MH, Lie Kl. Amyloid cardiomyopathy in systemic non-hereditary amyloidosis. Clinical, échocardiographie and electrocardiographic findings in 30 patients with AA and 24 patients with AL amyloidosis. Eur Heart J 1992;13:623-627.
  • Schattner A, Epstein M, Berrebi A, Caspi A. Case report: multiple myeloma presenting as a diastolic heart failure with no evidence of amyloidosis. Am J Med Sci 1995;310:256-257.
  • Mitchell MA, Horneffer MD. Standiford TJ. Multiple myeloma complicated by restrictive cardiomyopathy and cardiac tamponade. Chest 1993;103:946-947.
  • Gertz MA, Kyle RA. Primary systemic amyloidosis-a diagnostic primer. Mayo Clin Proc 1989;64:1505- 1519.
  • Reisinger J, Dubrey SW, Lavalley M, Skinner M, Falk RH. Electrophysiologic abnormalities in AL (primary) amyloidosis with cardiac involement. J Am Coll Cardiol 199 7;30:1046-1051.
  • Brandt K, Cathead E 5, Cohen A S. A clinical analysis of the course and prognosis of forty-two patients with amyloidosis. Am J Med 1968:44:955- 969.
  • Klein AL, Hatle LK, Taliercio CP, et al. Prognostic significance of Doppler measures of diastolic function in cardiac amyloidosis. A Doppler echocardiography study. Circulation 1991:83:808- 816.
  • Falk RH, Plehn JF, Deering T, et al. Sensitivity and specificity of the échocardiographie features of cardiac amyloidosis. Am J Cardiol 1987;59:418- 422.
  • Simons M, Isner JM. Assessment of relative sensitivities of noninvasive tests for cardiac amyloidosis in documented cardiac amyloidosis. Am J Cardiol 1992;69:425-427.
  • Dubrey SW, Cha K, Skinner M, La Valley M, Falk RH. Familial and primary (AL) cardiac amyloidosis: echocardiographically similar diseases with distinctly different clinical outcomes. Heart 1997;78:74-82.
  • Hesse A, Altland K, Linke RP, et al. Cardiac amyloidosis: a review and report of a new transthyretin (prealbumin) variant. Br Heart J 1993;70:1 I 1-115.
  • Tei C, Dujardin KS, Hodge DO, Kyle RA, Tajik AJ, Seward JB. Doppler index combining systolic and diastolic myocardial performance: clinical value in cardiac amyloidosis. J Am Coll Cardiol 1996; 28:658-664.
  • Arbustini E, Merlini G, Gavazzi A, et al. Cardiac
  • immunocyte-derived (AL) amyloidosis: an
  • endomyocardial biopsy study in 11 patients. Am Heart J 1995; 130:528-536.
  • Garcia L C, Tajik A J, Kyle R A, et al. Serial
  • échocardiographie observations in patients with primary systemic amyloidosis: an introduction to the concept of early (asymptomatic) amyloid infiltration of the heart. Mayo Clin Proc
  • ;59:589-597.
  • Pellikka P, Holmes D R, Edwards W D, et at Endomyocardial biopsy in 30 patients with primary amyloidosis and suspected cardiac involvement Arch Intern Med 1988;148:662-666.
  • McAllister H A, Seger J, Bossart M, Ferrans V J. Restrictive cardiomyopathy with kappa light chain deposits in myocardium as a complication of multiple myeloma. Arch Pathol Lab Med 1988:112:1 151-1 154.

Year 1999, Volume: 12 Issue: 2, 94 - 97, 03.12.2016

Sibel Ersan Refik Demirtunç Yıldırım Çınar

Abstract

References

  • O'Connell JB, Renland DO. Myocarditis and specific myocardial diseases. In: Schlant RC, Alexander RW, O'Rourke RA, et al (eds). Hurst's The Heart, 8^’ ed. Hew York, McGraw-Hill, 1994:1591 -1607.
  • Dubrey SIV, Cha R, Anderson J, et at. The clinical features of immunoglobulin light-chain (AL) amyloidosis with heart involvement (abstract). QJM 1998;91:141-157.
  • 6
  • Marmara Medical Journal Volume 12 No 2 April 1999
  • Vaitkus PT, Kussmaul WG. Constrictive pericarditis versus restrictive cardiomyopathy: a reappraisal and update of diagnostic criteria. Am Heart J 1991;122:1431-1441.
  • Hamer JP, Janssen S, Rijswijk van MH, Lie Kl. Amyloid cardiomyopathy in systemic non-hereditary amyloidosis. Clinical, échocardiographie and electrocardiographic findings in 30 patients with AA and 24 patients with AL amyloidosis. Eur Heart J 1992;13:623-627.
  • Schattner A, Epstein M, Berrebi A, Caspi A. Case report: multiple myeloma presenting as a diastolic heart failure with no evidence of amyloidosis. Am J Med Sci 1995;310:256-257.
  • Mitchell MA, Horneffer MD. Standiford TJ. Multiple myeloma complicated by restrictive cardiomyopathy and cardiac tamponade. Chest 1993;103:946-947.
  • Gertz MA, Kyle RA. Primary systemic amyloidosis-a diagnostic primer. Mayo Clin Proc 1989;64:1505- 1519.
  • Reisinger J, Dubrey SW, Lavalley M, Skinner M, Falk RH. Electrophysiologic abnormalities in AL (primary) amyloidosis with cardiac involement. J Am Coll Cardiol 199 7;30:1046-1051.
  • Brandt K, Cathead E 5, Cohen A S. A clinical analysis of the course and prognosis of forty-two patients with amyloidosis. Am J Med 1968:44:955- 969.
  • Klein AL, Hatle LK, Taliercio CP, et al. Prognostic significance of Doppler measures of diastolic function in cardiac amyloidosis. A Doppler echocardiography study. Circulation 1991:83:808- 816.
  • Falk RH, Plehn JF, Deering T, et al. Sensitivity and specificity of the échocardiographie features of cardiac amyloidosis. Am J Cardiol 1987;59:418- 422.
  • Simons M, Isner JM. Assessment of relative sensitivities of noninvasive tests for cardiac amyloidosis in documented cardiac amyloidosis. Am J Cardiol 1992;69:425-427.
  • Dubrey SW, Cha K, Skinner M, La Valley M, Falk RH. Familial and primary (AL) cardiac amyloidosis: echocardiographically similar diseases with distinctly different clinical outcomes. Heart 1997;78:74-82.
  • Hesse A, Altland K, Linke RP, et al. Cardiac amyloidosis: a review and report of a new transthyretin (prealbumin) variant. Br Heart J 1993;70:1 I 1-115.
  • Tei C, Dujardin KS, Hodge DO, Kyle RA, Tajik AJ, Seward JB. Doppler index combining systolic and diastolic myocardial performance: clinical value in cardiac amyloidosis. J Am Coll Cardiol 1996; 28:658-664.
  • Arbustini E, Merlini G, Gavazzi A, et al. Cardiac
  • immunocyte-derived (AL) amyloidosis: an
  • endomyocardial biopsy study in 11 patients. Am Heart J 1995; 130:528-536.
  • Garcia L C, Tajik A J, Kyle R A, et al. Serial
  • échocardiographie observations in patients with primary systemic amyloidosis: an introduction to the concept of early (asymptomatic) amyloid infiltration of the heart. Mayo Clin Proc
  • ;59:589-597.
  • Pellikka P, Holmes D R, Edwards W D, et at Endomyocardial biopsy in 30 patients with primary amyloidosis and suspected cardiac involvement Arch Intern Med 1988;148:662-666.
  • McAllister H A, Seger J, Bossart M, Ferrans V J. Restrictive cardiomyopathy with kappa light chain deposits in myocardium as a complication of multiple myeloma. Arch Pathol Lab Med 1988:112:1 151-1 154.
There are 25 citations in total.

Details

Journal Section Case Reports
Authors

Sibel Ersan This is me

Refik Demirtunç This is me

Yıldırım Çınar This is me

Publication Date December 3, 2016
Published in Issue Year 1999 Volume: 12 Issue: 2

Cite

APA Ersan, S., Demirtunç, R., & Çınar, Y. (2016). CARDIAC AMYLOIDOSIS AS A COMPLICATION OF MULTIPLE MYELOMA. Marmara Medical Journal, 12(2), 94-97.
AMA Ersan S, Demirtunç R, Çınar Y. CARDIAC AMYLOIDOSIS AS A COMPLICATION OF MULTIPLE MYELOMA. Marmara Med J. June 2016;12(2):94-97.
Chicago Ersan, Sibel, Refik Demirtunç, and Yıldırım Çınar. “CARDIAC AMYLOIDOSIS AS A COMPLICATION OF MULTIPLE MYELOMA”. Marmara Medical Journal 12, no. 2 (June 2016): 94-97.
EndNote Ersan S, Demirtunç R, Çınar Y (June 1, 2016) CARDIAC AMYLOIDOSIS AS A COMPLICATION OF MULTIPLE MYELOMA. Marmara Medical Journal 12 2 94–97.
IEEE S. Ersan, R. Demirtunç, and Y. Çınar, “CARDIAC AMYLOIDOSIS AS A COMPLICATION OF MULTIPLE MYELOMA”, Marmara Med J, vol. 12, no. 2, pp. 94–97, 2016.
ISNAD Ersan, Sibel et al. “CARDIAC AMYLOIDOSIS AS A COMPLICATION OF MULTIPLE MYELOMA”. Marmara Medical Journal 12/2 (June 2016), 94-97.
JAMA Ersan S, Demirtunç R, Çınar Y. CARDIAC AMYLOIDOSIS AS A COMPLICATION OF MULTIPLE MYELOMA. Marmara Med J. 2016;12:94–97.
MLA Ersan, Sibel et al. “CARDIAC AMYLOIDOSIS AS A COMPLICATION OF MULTIPLE MYELOMA”. Marmara Medical Journal, vol. 12, no. 2, 2016, pp. 94-97.
Vancouver Ersan S, Demirtunç R, Çınar Y. CARDIAC AMYLOIDOSIS AS A COMPLICATION OF MULTIPLE MYELOMA. Marmara Med J. 2016;12(2):94-7.