THE INFLUENCE OF ALTERED THYROID STATE ON GASTROINTESTINAL MOTILITY IN RATS

Yıl 2000, Cilt: 13 Sayı: 2, 64 - 69, 03.12.2016

Çağla Ayhan Salah Ghandour Levhi Akın Ahmet Karadağ Berrak Yeğen

Öz

Objective: Gastrointestinal symptoms frequently accompany thyroid dysfunction. Previous reports on the relationship between the thyroid status and the gut have conflicting results regarding gastric emptying and only a few experimental studies on colonic motility are present. This study was therefore designed to examine further the effects of changing thyroid hormone status on gastric emptying and to evaluate small intestinal and colonic motility in experimental hypo/hyperthyroidism in the rat.
Methods: Wistar-Albino rats (220-280 g) of both sexes were randomly treated with either Propylthiouracil (20 mg/kg/day, ip, 2 weeks; hypothyroid group) orT3 (1 mg/kg/day, ip, 7 days; hypertyroid group). Evaluation for daily food intake, gastric emptying, intestinal transit and colonic motility was performed.
Results: Daily food intake, fecal pellet number and gastric emptying rate were significantly reduced in hypothyroid rats. Both the daily stool volume and the number of fecal pellets were significantly higher in the hyperthyroid rats, whereas intestinal transit in 30 minutes remained unchanged both in the hyperthyoid and hypothyroid rats compared to control group.
Conclusion: The data from our experiments indicate that deviations from the normal euthyroid status in either direction principally affects colonic motility. Hypothyroidism seems to act in a broader spectrum, suggesting an overall inhibition in the gut motility.
Key Words: Thyroid hormones,
gastrointestinal motility, colon, gastric emptying, rat.

Kaynakça

• Sharma S, Longo WE, Baniadam B, Vernava AM. Colorectal manifestations of endocrine disease. Dis Colon Rectum 1995:38:318-323.
• Shafer RB, Prentiss RA, Bond Jfl. Gastrointestinal transit in thyroid disease. Gastroenterology 1984:86-852-855.
• Goto S, Billmire DE, Grosfeld JL. hypothyroidism impairs colonic motility and function: An experimental study in the rat. Eur J Pediatr Surg 1992;2:16-21.
• Jonderko R, Jonderko G, Marcisz C, Golab T. Gastric emptying in hyperthyroidism. Am J Gastroenterol 1997:92:835-838.
• Groskreutz JL, Rim Ch, McConahey WM. Acute gastroparesis associated with thyrotoxicosis. Am J Gastroenterol 1990;85:1206-1207.
• Derblom h, Johansson H, hylander G. Thyroid hormone activity and gastrointestinal function. Acta Chir Scand 1963;307(suppl): 1-
• Ikeda T, Eujiyoma R, hoshino T, et al. Glucose tolerance and gastric emptying in thyrotoxic rats. Metabolism 1989:38:874-877.
• Rahman Q, haboubi MY, Hudson PR, Lee GS, Shah IU. The effect of thyroxine on small intestinal motility in the elderly. Clin Endocrinol 1991,-35:443-446.
• Middleton WRJ. Thyroid hormones and the gut. Gut 1971,12:172-177.
• Tachman ML, Guthrie GP. hypothyroidism; diversity of presentation. Endocrine Reviews 1984;5:456-465.
• ll.Schreiber G, Aldred AR, Jaworowski A, hilsson C, Achen MG, Segal MB. Thyroxine transport from blood to brain via transthyretin synthesis in choroid plexus. Am J Physiol 1990;258:R338-R345.
• Gullo D, Sinha AR, Woods R, Pervin R, Ekins RP. Triiodothyronine binding in adult rat brain: compartimentation of receptor populations in purified neuronal and glial nuclei. Endocrinology (Baltimore) 1987; 120:325- 331.
• Atterwill CR, Bunn SJ, Atkinson DJ, Smith SL, heal DJ. Effects of thyroid status on
• Altered thyroid state on Gastrointestinal motility
• presynaptic a2-adrenoreceptor function and P-adrenoreceptor binding in the rat brain. J Pleural Transm 1984;59:43-55.
• Beiezikian JP, Loeb Jn. The influence of hyperthyroidism and hypothyroidism an a-and p-adrenergic receptor systems and adrenergic responsiveness. Endocr Rev 1983;4:378-388.
• Medina JH, Wolfman C, Levi de Stein M, Tumilasci O, floussay AB. Thyroid hormone regulation of adrenergic receptors and beta- adrenergic responsiveness in the rat submandibular gland. Life Sci 1984;35:819- 823.
• Stiles GL, Stadel JM, De Lean A, Lefkowitz R. Hypothyroidism modulates beta adrenergic receptor-adenylate cyclase interactions in rat reticulocytes. J Clin Invest 1981:68:1450- 1455.
• Mayer EA, Raybould HE. Role of visceral afferent mechanisms in functional bowel disorders. Gastroenterology 1990;99:1688- 1704.
• Henley WIT, Chen X, Klettner C, Bellush LL, Hotestine MA. Hypothyroidism increases serotonin turnover and sympathetic activity in the adult rat. Can J Physiol Pharmacol
• ;69-205-210.
• Lyrenas E, Abrahamsson H, Dotevall G. Effects of P-adrenoreceptor stimulation on rectosigmoid motility in man. Dig Dsi Sci 1985;30:536-540.
• Welch 1M, Sepple CP, Read IT W. Comparison of the effects on satiety and eating behaviour of infusion of lipid into different regions of the small intestine. Gut 1988;29:306-311.
• Kamal IT, Chami T, Andersen A, Rosell EA, Schuster MM, Whitehead WE. Delayed gastrointestinal transit times in anorexia nervosa and bulimia nervosa. Gastroenterology 1991,101:1320-1324.
• You le MS, Read ITW. Effect of painless rectal distension on gastrointestinal transit of solid meal. Dig Dsi Sci 1984;29:902-906.
• Bellow JE, Gill RC, Wingate DL. Modulation of upper gastrointestinal motility by rectal distension. Gut 1984;28:864-868.
• Hutson WR, Wald A. Gastric emptying in patients with bulimia nervosa and anorexia nervosa. Am J Gastroenterol 1990:85:4 1 -46.
• Holdsworth CD, Besser GM. Influence of gastric empying rate and of insulin response on oral glucose tolerance in thyroid disease. Lancet 1968;2:700-702.
• Wegener M, Wedmann B, Langhoff T, Schaffstein J, Adamek R. Effect of hyperthyroidism on the transit of a caloric solid-liquid meal through the stomach, the small intestine, and the colon in man. J Clin Endocrinol Metab 1992;75:745-749.