BibTex RIS Kaynak Göster

THE ROLE OF BASIC FIBROBLAST GROWTH FACTOR RECEPTOR (bFGF) AND C-KIT RECEPTOR IN PROGRESSION OF CUTANEOUS MELANOCYTIC LESIONS

Yıl 2002, Cilt: 15 Sayı: 1, 33 - 38, 03.12.2016

Öz

Objective: We investigated the expression of basic Fibroblast Growth Factor (bFGF) and c-kit proto-oncogene in progression to malignancy and métastasés of melanocytic lesions.
Methods: Immunohistochemical detection of bFGF and c-kit receptors were performed by peroxidase- antiperoxidase (PAP) technique on compound nevi, vertical growth phase malignant melanoma and metastatic malignant melanoma in 12, 12 and 15 cases respectively.
Clinicopathological correlations were analysed by Paerson’s Chi-Square, Student’s T-Test and One Way Anova test.
Results: bFGF receptor immunoreactivity rates were 83.3%, 83.3% and 80 % in compound nevi, primary MMs and metastatic MMs respectively, c-kit immunoreactivity was absent in nevus cells, but faintly present in 16.6 % (2 cases) of MM cells.
Conclusion: The results of our study suggest that loss of c-kit expression is more important in dermal penetration than métastasés in melanomas.However, bFGF is not shown to be a prognostic factor for MMs.
Key Words: c-kit, bFGF, Melanocytic nevi, Malignant melanoma, Metastatic melanoma

Kaynakça

  • Alberts B, Bray D, Lewis J, Raff M, Roberts R, Watson JD. Molecular Biology of the Cell. 2nd ed. London: Garland Publishing, Inc. 1989: 681-790.
  • flerlyn M, Mandanti ML, Jambrosic J, Bolen JB, Koprowski ft. Regulatory factors that determine growth and phenotype of normal human melanocytes. Exp Cell Res ¡988; I 79: 322-331.
  • Shih IM, flerlyn M. Autocrine and paracrine roles for growth factors in melanoma. In Vivo 1994; 8:1 13-123.
  • lialaban R, Pan B, Ahn J, Punasaka Y, Gitay- Goren fl, Heufeld G. Growth factors, receptor kinases, and protein tyrosine phosphatases innormal and malignant melonocytes. J
  • Immunother 1992; 12:154-161.
  • Halaban R. Growth factors and tyrosine protein kinases in normal and malignant melanocytes. Cancer Metastasis Rev 1991; 10: 129-140.
  • Huang S, Luca M, Gutman M, et al. Enforced c- kit expression renders highly metastatic human melanoma cells susceptible to stem cell factor induced apoptosis and inhibits their tumorigenic and metastatic potential. Oncogene 1996; 13: 2339-2347.
  • Zakut R, Pedis R, Eliyahu S, et al. KIT ligand (mast cell growth factor) inhibits the growth of KIT-expressing melanoma cells. Oncogene 1993; 8: 2221-2229.
  • Tsuura Y, Hiraki H, Watanabe K, et af Preferential localization of c-kit product in tissue mast cells, basal cells of skin, epithelial cells of breast, small cell lung carcinoma and seminoma/dysgerminoma in human: immunohistochemical study on formalin- fixed- paraffin-embedded tissues. Virchows Arch 1994; 424: 135-141.
  • Al-Alousi S, Barnhill R, Blessing K, Barksdale S. The prognostic significance of basic fibroblast growth factor in cutaneous malignant melanoma. J Cutan Pathol 1996; 23: 506-510.
  • Luo D, Chen H, Searles Cj, Jumbow K. Coordinated mRHA expression of c-Kit with tyrosinase and TRP-1 in melanine pigmentation of normal and malignant human melanocytes and transient activation of tyrosinase by Kit/SCP-R. Melanoma Res 1995; 5: 303-309.
  • I I. Hatali PG, nicotra MR, Winkler AB, Cavaliere R, Bigotti A, Ullrich A. Progression of human cutaneous melanoma is associated with loss of expression of c-kit proto-oncogene receptor. Int J Cancer 1992; 52: 197-201.
  • Yarden Y, Kuang WJ, Yang-Peng T, et af Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J 1988; 7:1003- 1011.
  • Giebel LB, Strunk KM, Holmes 5/1, Spritz RA. Organization and nucleotide sequence of the human KIT (mast/stem cell growth factor receptor) proto-oncogene. Oncogene 1992;7:2207-221 7.
  • Hiroto S, Isozaki K, Moriyama Y, et al. Gain of function mutation of c-kit in human gastrointestinal stromal tumors. Science 1998;279:577-580
  • Arber DA, Tamayo R, Weiss LM. Paraffin section detection of the c-kit gene product (CD 117) in human tissues: Value in the diagnosis of mast cell disorders. Hum Pathol 1998; 28: 498-504.
  • Ohashi A, Funasaka Y, Ueda M, Ichihashi M. C- kit receptor expression in cutaneous malignant melanoma and benign melanocytic naevi. Melanoma Res 1996; 6: 25-30.
  • Lu C, Kerbel RS. Cytokines, growth factors and the loss of negative growth controls in the progression of human cutaneous malignant melanoma. Curr Opin Oncol 1994; 6: 212- 220.
  • Moretti S, Pinzi C, Spallanzani A, et al. Immunohistochemical evidence of cytokine networks during progression of human melanocytic lesions. Int J Cancer 1999; 84: 160-168.
  • Takahashi H, Saitoh K, Kishi H, Parsons PG. Immunohistochemical localisation of stem cell factor (SCP) with comparison of its receptor c-Kit proto-oncogene product (c-KIT) in melanocytic tumours. Virchows Arch 1995;427:283-288.
  • Welker P, Schadendorf D, Artuc M, Grabbe J, Llenz BM. Expression of SCP splice variants in human melonocytes and melanoma cell lines: potential prognostic implications. Br J Cancer 2000:82: 1453-1458.
  • Papadimitriou CA, Topp MS, Serve H, et al. Recombinant human stem cell factor does exert minor stimulation of growth in small cell lung cancer and melanoma cell lines. Eur J Cancer 1995; 31 A: 2371-2378.
  • Salama S, Sircar K, Hewlett R. Kit expression in melanocytic lesions: An analysis of conventional nevi, Spitz and Reed's nevi, and melanoma. Am J Dermatopathol 1999; 21 : 595. (Abstracts : Joint Meeting of ISD)
  • Shin EY, Lee BH, Yang JH, et al. Up-regulation and co-expression of fibroblast growth factor receptors in human gastric cancer.J Cancer Res Clin Oncol 2000;126:519-528.
  • Ropiquet F, Giri D, Kwabi-Addo B, Mansukhani A, Ittmann M. Increased expression of fibroblast growth factor 6 in human prostatic intraepithelial neoplasia and prostate cancer.Cancer Res 2000;60:4245-4250.
  • Shemirani B,Crowe DL. Head and neck squamous cell carcinoma lines produce biologically active angiogenic factors. Oral Oncol 2000; 36: 61-66.
  • Alanko T, Rosenberg M, Saksela O. PGP expression allows nevus cells to survive in
  • 7
  • Esin Kotiloglu, et al
  • three-dimensional collagen gel under conditions that induce apoptosis in normal human melanocytes. J Invest Dermatol 1999; 113: 111-116.
  • Meier F, Hesbit M, Hsu MY, et al. Human melanoma progression in skin reconstructs : biological significance of bFGF. Am J Pathol 2000; 156: 193-200.
  • Ahmed HU, Ueda M, lto A, Ohashi A, Funasaka Y, Ichihashi M. Expression of fibroblast growth factor receptors in naevus-cell naevus and malignant melanoma. Melanoma Res 1997; 7: 299-305.
  • Yaguchi H, Tsuboi R, Ueki R, Ogawa 11. Immunohistochemical localization of basic fibroblast growth factor in skin diseases. Acta Derm Venereol 1993; 73: 81-83.
  • Birck A, Firkin AF, Zeuthen J, Hou-Jensen F. Expression of basic fibroblast growth factor
  • and vascular endothelial growth factor in primary and metastatic melanoma from the same patients. Melanoma Res 1999; 9: 375- 381.
  • Xerri L, Battyani Z, Grob JJ, et al. Expression of FGF1 and FGFR1 in human melanoma tissues. Melanoma Res 1996; 6:223-230.
  • Wang Y, Becker D. Antisense targeting of basic fibroblast growth factor and fibroblast growth factor receptor-1 in human melanomas blocks intratumoral angiogenesis and tumor growth. Hat Med 1997; 3: 887-893.
  • Rofstad EF, Halsor EF. Vascular endothelial growth factor, interleukin 8, platelet-derived endothelial cell growth factor, and basic fibroblast growth factor promote angiogenesis and metastasis in human melanoma
Yıl 2002, Cilt: 15 Sayı: 1, 33 - 38, 03.12.2016

Öz

Kaynakça

  • Alberts B, Bray D, Lewis J, Raff M, Roberts R, Watson JD. Molecular Biology of the Cell. 2nd ed. London: Garland Publishing, Inc. 1989: 681-790.
  • flerlyn M, Mandanti ML, Jambrosic J, Bolen JB, Koprowski ft. Regulatory factors that determine growth and phenotype of normal human melanocytes. Exp Cell Res ¡988; I 79: 322-331.
  • Shih IM, flerlyn M. Autocrine and paracrine roles for growth factors in melanoma. In Vivo 1994; 8:1 13-123.
  • lialaban R, Pan B, Ahn J, Punasaka Y, Gitay- Goren fl, Heufeld G. Growth factors, receptor kinases, and protein tyrosine phosphatases innormal and malignant melonocytes. J
  • Immunother 1992; 12:154-161.
  • Halaban R. Growth factors and tyrosine protein kinases in normal and malignant melanocytes. Cancer Metastasis Rev 1991; 10: 129-140.
  • Huang S, Luca M, Gutman M, et al. Enforced c- kit expression renders highly metastatic human melanoma cells susceptible to stem cell factor induced apoptosis and inhibits their tumorigenic and metastatic potential. Oncogene 1996; 13: 2339-2347.
  • Zakut R, Pedis R, Eliyahu S, et al. KIT ligand (mast cell growth factor) inhibits the growth of KIT-expressing melanoma cells. Oncogene 1993; 8: 2221-2229.
  • Tsuura Y, Hiraki H, Watanabe K, et af Preferential localization of c-kit product in tissue mast cells, basal cells of skin, epithelial cells of breast, small cell lung carcinoma and seminoma/dysgerminoma in human: immunohistochemical study on formalin- fixed- paraffin-embedded tissues. Virchows Arch 1994; 424: 135-141.
  • Al-Alousi S, Barnhill R, Blessing K, Barksdale S. The prognostic significance of basic fibroblast growth factor in cutaneous malignant melanoma. J Cutan Pathol 1996; 23: 506-510.
  • Luo D, Chen H, Searles Cj, Jumbow K. Coordinated mRHA expression of c-Kit with tyrosinase and TRP-1 in melanine pigmentation of normal and malignant human melanocytes and transient activation of tyrosinase by Kit/SCP-R. Melanoma Res 1995; 5: 303-309.
  • I I. Hatali PG, nicotra MR, Winkler AB, Cavaliere R, Bigotti A, Ullrich A. Progression of human cutaneous melanoma is associated with loss of expression of c-kit proto-oncogene receptor. Int J Cancer 1992; 52: 197-201.
  • Yarden Y, Kuang WJ, Yang-Peng T, et af Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J 1988; 7:1003- 1011.
  • Giebel LB, Strunk KM, Holmes 5/1, Spritz RA. Organization and nucleotide sequence of the human KIT (mast/stem cell growth factor receptor) proto-oncogene. Oncogene 1992;7:2207-221 7.
  • Hiroto S, Isozaki K, Moriyama Y, et al. Gain of function mutation of c-kit in human gastrointestinal stromal tumors. Science 1998;279:577-580
  • Arber DA, Tamayo R, Weiss LM. Paraffin section detection of the c-kit gene product (CD 117) in human tissues: Value in the diagnosis of mast cell disorders. Hum Pathol 1998; 28: 498-504.
  • Ohashi A, Funasaka Y, Ueda M, Ichihashi M. C- kit receptor expression in cutaneous malignant melanoma and benign melanocytic naevi. Melanoma Res 1996; 6: 25-30.
  • Lu C, Kerbel RS. Cytokines, growth factors and the loss of negative growth controls in the progression of human cutaneous malignant melanoma. Curr Opin Oncol 1994; 6: 212- 220.
  • Moretti S, Pinzi C, Spallanzani A, et al. Immunohistochemical evidence of cytokine networks during progression of human melanocytic lesions. Int J Cancer 1999; 84: 160-168.
  • Takahashi H, Saitoh K, Kishi H, Parsons PG. Immunohistochemical localisation of stem cell factor (SCP) with comparison of its receptor c-Kit proto-oncogene product (c-KIT) in melanocytic tumours. Virchows Arch 1995;427:283-288.
  • Welker P, Schadendorf D, Artuc M, Grabbe J, Llenz BM. Expression of SCP splice variants in human melonocytes and melanoma cell lines: potential prognostic implications. Br J Cancer 2000:82: 1453-1458.
  • Papadimitriou CA, Topp MS, Serve H, et al. Recombinant human stem cell factor does exert minor stimulation of growth in small cell lung cancer and melanoma cell lines. Eur J Cancer 1995; 31 A: 2371-2378.
  • Salama S, Sircar K, Hewlett R. Kit expression in melanocytic lesions: An analysis of conventional nevi, Spitz and Reed's nevi, and melanoma. Am J Dermatopathol 1999; 21 : 595. (Abstracts : Joint Meeting of ISD)
  • Shin EY, Lee BH, Yang JH, et al. Up-regulation and co-expression of fibroblast growth factor receptors in human gastric cancer.J Cancer Res Clin Oncol 2000;126:519-528.
  • Ropiquet F, Giri D, Kwabi-Addo B, Mansukhani A, Ittmann M. Increased expression of fibroblast growth factor 6 in human prostatic intraepithelial neoplasia and prostate cancer.Cancer Res 2000;60:4245-4250.
  • Shemirani B,Crowe DL. Head and neck squamous cell carcinoma lines produce biologically active angiogenic factors. Oral Oncol 2000; 36: 61-66.
  • Alanko T, Rosenberg M, Saksela O. PGP expression allows nevus cells to survive in
  • 7
  • Esin Kotiloglu, et al
  • three-dimensional collagen gel under conditions that induce apoptosis in normal human melanocytes. J Invest Dermatol 1999; 113: 111-116.
  • Meier F, Hesbit M, Hsu MY, et al. Human melanoma progression in skin reconstructs : biological significance of bFGF. Am J Pathol 2000; 156: 193-200.
  • Ahmed HU, Ueda M, lto A, Ohashi A, Funasaka Y, Ichihashi M. Expression of fibroblast growth factor receptors in naevus-cell naevus and malignant melanoma. Melanoma Res 1997; 7: 299-305.
  • Yaguchi H, Tsuboi R, Ueki R, Ogawa 11. Immunohistochemical localization of basic fibroblast growth factor in skin diseases. Acta Derm Venereol 1993; 73: 81-83.
  • Birck A, Firkin AF, Zeuthen J, Hou-Jensen F. Expression of basic fibroblast growth factor
  • and vascular endothelial growth factor in primary and metastatic melanoma from the same patients. Melanoma Res 1999; 9: 375- 381.
  • Xerri L, Battyani Z, Grob JJ, et al. Expression of FGF1 and FGFR1 in human melanoma tissues. Melanoma Res 1996; 6:223-230.
  • Wang Y, Becker D. Antisense targeting of basic fibroblast growth factor and fibroblast growth factor receptor-1 in human melanomas blocks intratumoral angiogenesis and tumor growth. Hat Med 1997; 3: 887-893.
  • Rofstad EF, Halsor EF. Vascular endothelial growth factor, interleukin 8, platelet-derived endothelial cell growth factor, and basic fibroblast growth factor promote angiogenesis and metastasis in human melanoma
Toplam 38 adet kaynakça vardır.

Ayrıntılar

Bölüm Original Research
Yazarlar

Esin Kotiloğlu Bu kişi benim

Handan Kaya Bu kişi benim

Saime Sezgin Bu kişi benim

Gülsün Ekicioğlu Bu kişi benim

Yayımlanma Tarihi 3 Aralık 2016
Yayımlandığı Sayı Yıl 2002 Cilt: 15 Sayı: 1

Kaynak Göster

APA Kotiloğlu, E., Kaya, H., Sezgin, S., Ekicioğlu, G. (2016). THE ROLE OF BASIC FIBROBLAST GROWTH FACTOR RECEPTOR (bFGF) AND C-KIT RECEPTOR IN PROGRESSION OF CUTANEOUS MELANOCYTIC LESIONS. Marmara Medical Journal, 15(1), 33-38.
AMA Kotiloğlu E, Kaya H, Sezgin S, Ekicioğlu G. THE ROLE OF BASIC FIBROBLAST GROWTH FACTOR RECEPTOR (bFGF) AND C-KIT RECEPTOR IN PROGRESSION OF CUTANEOUS MELANOCYTIC LESIONS. Marmara Med J. Mart 2016;15(1):33-38.
Chicago Kotiloğlu, Esin, Handan Kaya, Saime Sezgin, ve Gülsün Ekicioğlu. “THE ROLE OF BASIC FIBROBLAST GROWTH FACTOR RECEPTOR (bFGF) AND C-KIT RECEPTOR IN PROGRESSION OF CUTANEOUS MELANOCYTIC LESIONS”. Marmara Medical Journal 15, sy. 1 (Mart 2016): 33-38.
EndNote Kotiloğlu E, Kaya H, Sezgin S, Ekicioğlu G (01 Mart 2016) THE ROLE OF BASIC FIBROBLAST GROWTH FACTOR RECEPTOR (bFGF) AND C-KIT RECEPTOR IN PROGRESSION OF CUTANEOUS MELANOCYTIC LESIONS. Marmara Medical Journal 15 1 33–38.
IEEE E. Kotiloğlu, H. Kaya, S. Sezgin, ve G. Ekicioğlu, “THE ROLE OF BASIC FIBROBLAST GROWTH FACTOR RECEPTOR (bFGF) AND C-KIT RECEPTOR IN PROGRESSION OF CUTANEOUS MELANOCYTIC LESIONS”, Marmara Med J, c. 15, sy. 1, ss. 33–38, 2016.
ISNAD Kotiloğlu, Esin vd. “THE ROLE OF BASIC FIBROBLAST GROWTH FACTOR RECEPTOR (bFGF) AND C-KIT RECEPTOR IN PROGRESSION OF CUTANEOUS MELANOCYTIC LESIONS”. Marmara Medical Journal 15/1 (Mart 2016), 33-38.
JAMA Kotiloğlu E, Kaya H, Sezgin S, Ekicioğlu G. THE ROLE OF BASIC FIBROBLAST GROWTH FACTOR RECEPTOR (bFGF) AND C-KIT RECEPTOR IN PROGRESSION OF CUTANEOUS MELANOCYTIC LESIONS. Marmara Med J. 2016;15:33–38.
MLA Kotiloğlu, Esin vd. “THE ROLE OF BASIC FIBROBLAST GROWTH FACTOR RECEPTOR (bFGF) AND C-KIT RECEPTOR IN PROGRESSION OF CUTANEOUS MELANOCYTIC LESIONS”. Marmara Medical Journal, c. 15, sy. 1, 2016, ss. 33-38.
Vancouver Kotiloğlu E, Kaya H, Sezgin S, Ekicioğlu G. THE ROLE OF BASIC FIBROBLAST GROWTH FACTOR RECEPTOR (bFGF) AND C-KIT RECEPTOR IN PROGRESSION OF CUTANEOUS MELANOCYTIC LESIONS. Marmara Med J. 2016;15(1):33-8.