DISEASE ACTIVITY AND FUNCTIONAL STATUS IN TURKISH PATIENTS WITH RHEUMATOID ARTHRITIS

Yıl 2003, Cilt: 16 Sayı: 2, 85 - 89, 03.12.2016

Nuray Geçer Şule Yavuz Pamir Atagündüz Nevsun Arıtan Haner Direskeneli

Öz

Objective: Turkish patients with rheumatoid arthritis (RA) followed in a university rheumatology clinic, were evaluated cross- sectionally for clinical, socio-economical and laboratory features, correlations with disease activity (DAS) and functional outcome were assessed using a Modified Health Assessment Questionnaire (M-HAQ).
Methods: Sixty-five patients with RA (F/M: 8/1, mean age: 49.7 + 11,9 years) were investigated. Besides socio-demographic evaluations, patients were analyzed for clinical disease activity, laboratory findings and medication. Univariate and logistic regression analysis of the scores with DAS and M-HAQ were performed.
Results: Despite a long disease duration (97,0+76,9 months) the functional indices (M- HAQ: 0,6+0,6 and ACR: 2,1+0,9) of the patients were limitedly elevated. However, pain visual analog scale (VAS: 3,5+2,7), tender joint score (TJS: 8,3+8,3), swollen joint score (SJS: 1,9+3,2), disease activity score (DAS: 3,3+1,3), deformed joint score (DJS: 3,2+5,6) and acute phase responses (ESR: 57,8+58,2 mm/h, CRP: 15,9+15,2 mg/dl) were moderately high in our population. DAS was found to correlate with most
activity criteria, whereas M-HAQ had a limited correlation.
Conclusion: Our results suggest that the average RA patient has a limited disability after a mean of 8 years of disease duration in a Turkish university clinic setting. However, disease activity was not suppressed adequately in most patients. DAS was observed to be a good composite measure of disease activity, in good correlation with most single activity measurements.
Key Words: Rheumatoid arthritis, Disease activity scores, Health Assessment Questionnaires

Kaynakça

• Imeryuz H, Yazıcı M, Koçak: Pericardial and puimanory invoiment in rheumatoid artritis in Turkey. Clin Rheumatol 1994:13:243.
• Istanbul Rheumatology Study Group and G. Saruhan-Direskeneli. Shared epitope
• 8
• Disease activity and functional status in Turkish patients with RA
• 'homozygosity' is strongly associated with rheumatoid arthritis in Turkey. Br J Rheumatol 1998:37:1126-1 128.
• Arnett TC, Edworthy SM, Bloch DA, et at. The American Rheumatism Assosication 1987 Revised Criteria for the Classification of Rheumatoid Arthritis. Arthritis Rheum 1998; 31:315-324.
• Şenerdem Ti, Gül A, Ronice M, et al. The Use of Two Different Health Assessment Questionnaires in Turkish Rheumatoid Arthritis Population and Assessment of the Associations with Disability. Clin Rheumatol 1999;18:33-37.
• Ward TIM, Leigh JP, Marital status and the progression of functional disability in patients with rheumatoid arthritis. Arthritis Rheum 1993;36:589-592.
• Wolfe F. The effect of smoking on clinical, laboratory, and radiographic status in rheumatoid arthritis. J Rheumatol, 2000;27:3.
• Villaverde V, Balsa A, Cantalejo M, et al. Activity indices in rheumatoid arthritis. J Rheumatol 2000;2 7:25 76-2581.
• Prevoo ML, van Hof MA, Ruper Htl, van Leeuwen MA, van de Putte LB, van Riel PL. Modified disease activity scores that include twenty- eigth- joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum 1995,38:44-
• Prevoo ML, van Gestel AM, van T. Hof MA, van Rijswijk MH, van de Putte LB, van Riel PL. Remission in a prospective study of patients with rheumatoid arthritis. American Rheumatism Association Preminary Criteria in Relation to the Disease Activity Score. Br J Rheumatol 1996:35:1039-1040.
• Salaffi F, Peroni M, Ferraccioli GF. Discriminating ability of composite indices for measuring disease activity in rheumatoid arthritis: a comparison of the cronic arthritis systemic index, disease activity score and Thompson's Articular Index. Rheumatology (Oxford) 2000;39:90-96.
• Welsing PMJ, van Gestel AM, Swinkels I1L, Riemeney LALM, van Riel PLCM. The relationship between disease activity joint destruction, and functional capasity over the course of rheumatoid arthritis. Arthritis Rheum 2001;444:2009-2017.
• Greenwood MC, Doyle DV, Ensor M. Does the Stanford Health Assessment Questionnaire have potential as a monitoring tool for subjects with rheumatoid arthritis?. Ann Rheum 2001 ,-60:344-348.
• Jansen LM, van Schaardenburg D, van Der Horst-Bruinsma IE, Bezemer PD, Dijkmans BA. Predictors of functional status in patients with early rheumatoid arthritis. Ann. Rheum Dis Mar 2000;59:223-226.
• Wolfe F. A Reappraisal of HAQ disability in Rheumatoid Arthritis. Arthritis Rheum 2000; 43:2751-2761.