Cerebellar Extraventricular Neurocytoma with Spinal Seeding

Aşkın Şeker; Bahattin Tanrıkulu; Ulaş Yener; Zafer Toktaş; Türker Kılıç

Cerebellar Extraventricular Neurocytoma with Spinal Seeding

Year 2012, Volume: 25 Issue: 1, 37 - 40, 02.03.2015

Aşkın Şeker , Bahattin Tanrıkulu Ulaş Yener Zafer Toktaş Türker Kılıç

Abstract

Central neurocytomas are typically located in lateral or third ventricles. Here, we report a case of neurocytoma located in the middle cerebellar peduncle. A 36-year-old male patient presented with symptoms of ataxic gait and urinary incontinence for one month. Magnetic resonance imaging (MRI) of the brain revealed a slightly enhanced lesion on the left middle cerebellar peduncle with obstructive hydrocephalus. The preoperative diagnosis was a glial tumor and a subtotal surgical removal was performed. Following pathological studies, the final definitive diagnosis was made as central neurocytoma. Six months after surgery, the patient presented with low back pain and bilateral lower extremity weakness. Lumbar MRI studies revealed multiple intradural-extramedulary lesions. The patient was not operated for spinal lesions. He was treated with palliative radiotherapy in the metastatic spinal area. Cerebellar peduncle is an atypical location for a neurocytoma. Neurocytomas in atypical locations may behave more aggressively and make spinal seeding. According to neuroradiological and clinical presentation, these tumors may have been confused with other common cerebellar lesions. Pathological examination is needed for definitive diagnosis. Favorable prognosis is related to total tumor excision. (Marmara Medical Journal 2012;25:37-40)

Key Words: Extraventricular neurocytoma, Spinal bleeding, Cerebellum

Keywords

References

1. Hassoun J, Gambarelli D, Grisoli F, et al. Central neurocytoma. An electron-microscopic study of two cases. Acta Neuropathol 1982;56:151-6. doi: 10.1007/BF00690587
2. Hassoun J, Soylemezoglu F, Gambarelli D, Figarella-Branger D, von Ammon K, Kleihues P. Central neurocytoma: a synopsis of clinical and histological features. Brain Pathol 1993;3:297-306. doi: 10.1111/j.1750-3639.1993.tb00756.x
3. Agranovich AL, Ang LC, Fryer CJ. Central neurocytoma: report of 2 cases and literature review. J Neurooncol 1993;16:47-53. doi: 10.1007/BF01324834
4. Brat D, Scheithauer B, Eberhart C, Burger P. Extraventricular neurocytomas. Pathologic features and clinical outcome. Am J Surg Pathol 2002;25:1252-60.
5. Sgouros S, Walsh AR, Barber P. Central neurocytoma of thalamic origin. Br J Neurosurg 1994;8:373-6. doi:10.1016/0090- 3019(94)90405-7
6. Pal L, Santosh V, Gayathri N, et al. Neurocytoma/rhabdomyoma (myoneurocytoma) of the cerebellum. Acta Neuropathol (Berl)1998;95:318-23. doi: 10.1007/s004010050805
7. Soontornniyokkij V, Schelper R. Pontine neurocytoma. J Clin Pathol 1996;49:764-5.
8. Gomes FL, Franca LR, Zymberg ST, Cavalheiro S. Central neurocytomas of uncommon locations: report of two cases. Arq Neuropsiquiatr 2006;64:1015-8. dx.doi.org/10.1590/S0004- 282X2006000600025
9. Metcalf C, Mele E, McAllister I. Neurocytoma of th retina. Br J Ophthalmol 1993;77:382-4.
10. Martin AJ, Sharr MM, Teddy PJ, Gardner BP, Robinson SF. Neurocytoma of the thoracic spinal cord. Acta Neurochir (Wien) 2002;144:823-8. doi: 10.1007/s00701-002-0980-z
11. Sharma S, Sarkar C, Gaikwad S, Suri A, Sharma MC. Primary neurocytoma of the spinal cord: a case report and review of literature. J Neurooncol 2005;74:47-52. doi: 10.1007/s11060-004-3348-9
12. Chou YY, Lee CC, Chen TJ, Wei CP. Atypical central neurocytoma: report of a case. J Formos Med Assoc 1999;98:573-7.
13. Soylemezoglu F, Scheithauer BW, Esteve J, Kleihues P. Atypical central neurocytoma. J Neuropathol Exp Neurol 1997;56:551-6.
14. Nishio S, Takeshita I, Kaneko Y, Fukui M. Cerebral neurocytoma. A new subset of benign neuronal tumors of the cerebrum. Cancer 1992; 70:529-37. doi: 10.1002/1097-0142(19920715)70:2<529: :AID-CNCR2820700225>3.0.CO;2-0
15. Coca S, Moreno M, Martos J, Rodriguez J, Barecena A, Vaquero J. Neurocytoma of spinal cord. Acta Neuropathol (Berl) 1994;87:537- 40. doi: 10.1007/BF0029418
16. Stapleton SR, David KM, Harkness WF, Harding BN. Central neurocytoma of the cervical spinal cord. J Neurol Neurosurg Psychiatry 1997;63:119-20.
17. Tatter SB, Borges LF, Louis DN. Central neurocytomas of the cervical spinal cord. Report of two cases. J Neurosurg 1994;81:288-93.
18. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, (editors) World Health Organization Classification of Tumours of the Central Nervous System. 4 ed. Lyon: International Agency for Research on Cancer Press, 2007.
19. Eng DY, DeMonte F, Ginsberg L, Fuller GN, Jaeckle K. Craniospinal dissemination of central neurocytoma. Report of two cases. J Neurosurg 1997;86:547-52.
20. Figarella-Branger D, Pellissier J, Daumas-Duport C, al. E. Central neurocytomas: critical evaluation of a small cell neuronal tumor. Am J Surg Pathol 1992;16:97-106.
21. Kim DG, Paek SH, Kim IH, et al. Central neurocytoma: the role of radiation therapy and long term outcome. Cancer 1997;79:1995- 2002. doi: 10.1002/(SICI)1097-0142(19970515)79:10<1995::AIDCNCR22>3.0.CO;2-P
22. Sgouros S, Carey M, Aluwihare N, Barber P, Jackowski A. Central neurocytoma: a correlative clinicopathologic and radiologic analysis. Surg Neurol 1998;49:197-204. doi : 16065, 35400007826903.0110
23. Schweitzer JB, Davies KG. Differentiating central neurocytoma. Case report. J Neurosurg 1997;86:543-6.
24. Horoupian DS, Shuster DL, Kaarsoo-Herrick M, Shuer LM. Central neurocytoma: one associated with a fourth ventricular PNET/medulloblastoma and the second mixed with adipose tissue. Hum Pathol 1997;28:1111-4. doi:10.1016/S0046-8177(97)90066-6
25. Ishiuchi S, Tamura M. Central neurocytoma: an immunohistochemical, ultrastructural and cell culture study. Acta Neuropathol 1997;94:425- 35. doi: 10.1007/s00401005072
26. Mackenzie IR. Central neurocytoma: histologic atypia, proliferation potential, and clinical outcome. Cancer 1999;85:1606-10. doi: 10.1002/(SICI)1097-0142(19990401)85:7<1606::AIDCNCR24>3.0.CO;2-B
27. Warmuth-Metz M, Klein R, Sorensen N, Solymosi L. Central neurocytoma of the fourth ventricle. Case report. J Neurosurg 1999;91:506-9.
28. Sharma MC, Sarkar C, Karak AK, Gaikwad S, Mahapatra AK, Mehta VS. Intraventricular neurocytoma: a clinicopathological study of 20 cases with review of the literature. J Clin Neurosci 1999;6:319-23. doi:10.1016/S0967-5868(99)90055-3
29. Singh I, Pal G, (editors). Human embryology. 8 ed. India: MacMillan, 2007.
30. Katati MJ, Vilchez R, Ros B, Horcajadas A, Arraez MA, Arjona V. Central neurocytoma: analysis of three cases and review of the literature. Rev Neurol 1999;28:713-7.
31. Muragaki Y, Chernov M, Tajika Y, et al. Coincidence of central neurocytoma and multiple glioblastomas: a rare case report. J Neurooncol 2009;93:431-5. doi: 10.1007/s11060-008-9793-0
32. Leenstra JL, Rodriguez FJ, Frechette CM, et al. Central neurocytoma: management recommendations based on a 35-year experience. Int J Radiat Oncol Biol Phys 2007;67:1145-54. doi:10.1016/j.ijrobp.2006.10.018
33. Rades D, Schild SE. Is 50 Gy sufficient to achieve long-term local control after incomplete resection of typical neurocytomas? Strahlenther Onkol 2006;182:415-8. doi: 10.1007/s00066-006- 1522-z

Serebellar Ekstraventriküler Nörositom: Olgu Sunumu

Year 2012, Volume: 25 Issue: 1, 37 - 40, 02.03.2015

Aşkın Şeker , Bahattin Tanrıkulu Ulaş Yener Zafer Toktaş Türker Kılıç

Abstract

Nörositomlar tipik olarak lateral ya da 3. ventrikül yerleşimli tümörlerdir. Bu
yazıda serebellar pedinkül yerleşimli extraventriküler nörositom olgusu
sunulmaktadır.
36 yaşında erkek hasta bir aydır olan idrar inkontinansı ve ataksik yürüyüş ile
kliniğe başvurdu. Yapılan magnetik rezonans (MR) görüntülemelerinde sol orta
serebellar pedinkül yerleşimli minimal kontrast tutulumu olan lezyon ve
obstrüktif hidrosefali saptandı. Hasta opere edildi. Lezyon subtotal rezeke
edildi. Lezyonun patoloji sonucu santral nörositom ile uyumlu idi.
Operasyondan 6 ay sonra hasta kliniğe bel ve her iki bacak ağrısı ile başvurdu.
Yapılan lomber MR görüntülemelerinde çok sayıda intradural ekstramedüller
lezyonlar saptandı. Hasta bu lezyonlarına yönelik opere edilmedi. Radyasyon
Onkolojisi’nin görüşü üzerine metastatik spinal bögeye palyatif radyoterapi
aldı. Serebellar pedinkül santral nörositom için alışılmış bir lokalizasyon değildir.
Ventrikül dışında yerleşen nörositomlar daha agresif davranabilir ve spinal
metastazlar yapabilirler. Nöroradyolojik görünümleri diğer serebellar
lezyonlarla karıştırılabilir. Kesin tanı için patolojik inceleme hayati önem
taşımaktadır. Total rezeksiyon prognoza olumlu yönde katkı sağlamaktadır.

Keywords

Ekstraventriculer nörositom, Spinal metastaz, Cerebellum

References

1. Hassoun J, Gambarelli D, Grisoli F, et al. Central neurocytoma. An electron-microscopic study of two cases. Acta Neuropathol 1982;56:151-6. doi: 10.1007/BF00690587
2. Hassoun J, Soylemezoglu F, Gambarelli D, Figarella-Branger D, von Ammon K, Kleihues P. Central neurocytoma: a synopsis of clinical and histological features. Brain Pathol 1993;3:297-306. doi: 10.1111/j.1750-3639.1993.tb00756.x
3. Agranovich AL, Ang LC, Fryer CJ. Central neurocytoma: report of 2 cases and literature review. J Neurooncol 1993;16:47-53. doi: 10.1007/BF01324834
4. Brat D, Scheithauer B, Eberhart C, Burger P. Extraventricular neurocytomas. Pathologic features and clinical outcome. Am J Surg Pathol 2002;25:1252-60.
5. Sgouros S, Walsh AR, Barber P. Central neurocytoma of thalamic origin. Br J Neurosurg 1994;8:373-6. doi:10.1016/0090- 3019(94)90405-7
6. Pal L, Santosh V, Gayathri N, et al. Neurocytoma/rhabdomyoma (myoneurocytoma) of the cerebellum. Acta Neuropathol (Berl)1998;95:318-23. doi: 10.1007/s004010050805
7. Soontornniyokkij V, Schelper R. Pontine neurocytoma. J Clin Pathol 1996;49:764-5.
8. Gomes FL, Franca LR, Zymberg ST, Cavalheiro S. Central neurocytomas of uncommon locations: report of two cases. Arq Neuropsiquiatr 2006;64:1015-8. dx.doi.org/10.1590/S0004- 282X2006000600025
9. Metcalf C, Mele E, McAllister I. Neurocytoma of th retina. Br J Ophthalmol 1993;77:382-4.
10. Martin AJ, Sharr MM, Teddy PJ, Gardner BP, Robinson SF. Neurocytoma of the thoracic spinal cord. Acta Neurochir (Wien) 2002;144:823-8. doi: 10.1007/s00701-002-0980-z
11. Sharma S, Sarkar C, Gaikwad S, Suri A, Sharma MC. Primary neurocytoma of the spinal cord: a case report and review of literature. J Neurooncol 2005;74:47-52. doi: 10.1007/s11060-004-3348-9
12. Chou YY, Lee CC, Chen TJ, Wei CP. Atypical central neurocytoma: report of a case. J Formos Med Assoc 1999;98:573-7.
13. Soylemezoglu F, Scheithauer BW, Esteve J, Kleihues P. Atypical central neurocytoma. J Neuropathol Exp Neurol 1997;56:551-6.
14. Nishio S, Takeshita I, Kaneko Y, Fukui M. Cerebral neurocytoma. A new subset of benign neuronal tumors of the cerebrum. Cancer 1992; 70:529-37. doi: 10.1002/1097-0142(19920715)70:2<529: :AID-CNCR2820700225>3.0.CO;2-0
15. Coca S, Moreno M, Martos J, Rodriguez J, Barecena A, Vaquero J. Neurocytoma of spinal cord. Acta Neuropathol (Berl) 1994;87:537- 40. doi: 10.1007/BF0029418
16. Stapleton SR, David KM, Harkness WF, Harding BN. Central neurocytoma of the cervical spinal cord. J Neurol Neurosurg Psychiatry 1997;63:119-20.
17. Tatter SB, Borges LF, Louis DN. Central neurocytomas of the cervical spinal cord. Report of two cases. J Neurosurg 1994;81:288-93.
18. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, (editors) World Health Organization Classification of Tumours of the Central Nervous System. 4 ed. Lyon: International Agency for Research on Cancer Press, 2007.
19. Eng DY, DeMonte F, Ginsberg L, Fuller GN, Jaeckle K. Craniospinal dissemination of central neurocytoma. Report of two cases. J Neurosurg 1997;86:547-52.
20. Figarella-Branger D, Pellissier J, Daumas-Duport C, al. E. Central neurocytomas: critical evaluation of a small cell neuronal tumor. Am J Surg Pathol 1992;16:97-106.
21. Kim DG, Paek SH, Kim IH, et al. Central neurocytoma: the role of radiation therapy and long term outcome. Cancer 1997;79:1995- 2002. doi: 10.1002/(SICI)1097-0142(19970515)79:10<1995::AIDCNCR22>3.0.CO;2-P
22. Sgouros S, Carey M, Aluwihare N, Barber P, Jackowski A. Central neurocytoma: a correlative clinicopathologic and radiologic analysis. Surg Neurol 1998;49:197-204. doi : 16065, 35400007826903.0110
23. Schweitzer JB, Davies KG. Differentiating central neurocytoma. Case report. J Neurosurg 1997;86:543-6.
24. Horoupian DS, Shuster DL, Kaarsoo-Herrick M, Shuer LM. Central neurocytoma: one associated with a fourth ventricular PNET/medulloblastoma and the second mixed with adipose tissue. Hum Pathol 1997;28:1111-4. doi:10.1016/S0046-8177(97)90066-6
25. Ishiuchi S, Tamura M. Central neurocytoma: an immunohistochemical, ultrastructural and cell culture study. Acta Neuropathol 1997;94:425- 35. doi: 10.1007/s00401005072
26. Mackenzie IR. Central neurocytoma: histologic atypia, proliferation potential, and clinical outcome. Cancer 1999;85:1606-10. doi: 10.1002/(SICI)1097-0142(19990401)85:7<1606::AIDCNCR24>3.0.CO;2-B
27. Warmuth-Metz M, Klein R, Sorensen N, Solymosi L. Central neurocytoma of the fourth ventricle. Case report. J Neurosurg 1999;91:506-9.
28. Sharma MC, Sarkar C, Karak AK, Gaikwad S, Mahapatra AK, Mehta VS. Intraventricular neurocytoma: a clinicopathological study of 20 cases with review of the literature. J Clin Neurosci 1999;6:319-23. doi:10.1016/S0967-5868(99)90055-3
29. Singh I, Pal G, (editors). Human embryology. 8 ed. India: MacMillan, 2007.
30. Katati MJ, Vilchez R, Ros B, Horcajadas A, Arraez MA, Arjona V. Central neurocytoma: analysis of three cases and review of the literature. Rev Neurol 1999;28:713-7.
31. Muragaki Y, Chernov M, Tajika Y, et al. Coincidence of central neurocytoma and multiple glioblastomas: a rare case report. J Neurooncol 2009;93:431-5. doi: 10.1007/s11060-008-9793-0
32. Leenstra JL, Rodriguez FJ, Frechette CM, et al. Central neurocytoma: management recommendations based on a 35-year experience. Int J Radiat Oncol Biol Phys 2007;67:1145-54. doi:10.1016/j.ijrobp.2006.10.018
33. Rades D, Schild SE. Is 50 Gy sufficient to achieve long-term local control after incomplete resection of typical neurocytomas? Strahlenther Onkol 2006;182:415-8. doi: 10.1007/s00066-006- 1522-z

There are 33 citations in total.

Details

Primary Language	English
Journal Section	Case Reports
Authors	Aşkın Şeker Bahattin Tanrıkulu This is me Ulaş Yener This is me Zafer Toktaş This is me Türker Kılıç This is me
Publication Date	March 2, 2015
Published in Issue	Year 2012 Volume: 25 Issue: 1

Cite

APA	Şeker, A., Tanrıkulu, B., Yener, U., Toktaş, Z., et al. (2015). Cerebellar Extraventricular Neurocytoma with Spinal Seeding. Marmara Medical Journal, 25(1), 37-40.
AMA	Şeker A, Tanrıkulu B, Yener U, Toktaş Z, Kılıç T. Cerebellar Extraventricular Neurocytoma with Spinal Seeding. Marmara Med J. August 2015;25(1):37-40.
Chicago	Şeker, Aşkın, Bahattin Tanrıkulu, Ulaş Yener, Zafer Toktaş, and Türker Kılıç. “Cerebellar Extraventricular Neurocytoma With Spinal Seeding”. Marmara Medical Journal 25, no. 1 (August 2015): 37-40.
EndNote	Şeker A, Tanrıkulu B, Yener U, Toktaş Z, Kılıç T (August 1, 2015) Cerebellar Extraventricular Neurocytoma with Spinal Seeding. Marmara Medical Journal 25 1 37–40.
IEEE	A. Şeker, B. Tanrıkulu, U. Yener, Z. Toktaş, and T. Kılıç, “Cerebellar Extraventricular Neurocytoma with Spinal Seeding”, Marmara Med J, vol. 25, no. 1, pp. 37–40, 2015.
ISNAD	Şeker, Aşkın et al. “Cerebellar Extraventricular Neurocytoma With Spinal Seeding”. Marmara Medical Journal 25/1 (August 2015), 37-40.
JAMA	Şeker A, Tanrıkulu B, Yener U, Toktaş Z, Kılıç T. Cerebellar Extraventricular Neurocytoma with Spinal Seeding. Marmara Med J. 2015;25:37–40.
MLA	Şeker, Aşkın et al. “Cerebellar Extraventricular Neurocytoma With Spinal Seeding”. Marmara Medical Journal, vol. 25, no. 1, 2015, pp. 37-40.
Vancouver	Şeker A, Tanrıkulu B, Yener U, Toktaş Z, Kılıç T. Cerebellar Extraventricular Neurocytoma with Spinal Seeding. Marmara Med J. 2015;25(1):37-40.

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