Yıl 2012,
Cilt: 25 Sayı: 2, 74 - 77, 17.03.2015
Öz
-
Anahtar Kelimeler
Kaynakça
- Jemal A, Siegel R, Xu J, et al. Cancer statistics, 2010. CA Cancer J Clin
- ; 60: 277–300. doi: 10.3322/caac.20073
- Sagar PM, Gauperaa T, Suc-Ling H, et al. An audit of the treatment of the
- cancer of the oesophagus. Gut 1994; 35: 941-5.
- Daly JM, Karnell LH, Menck HR. National Cancer Data Base report on
- esophageal carcinoma. Cancer 1996; 78: 1820-8. doi: 10.1002/
- (SICI)1097-0142(19961015)78:8<1820
- Kelsen DP, Ginsberg R, Pajak TF, et al. Chemotherapy followed by surgery
- compared with surgery alone for localized esophageal cancer. N Eng J
- Med 1998; 339:1979-84.
- Herskovic A, Martz K, Al-Sarraf MV, et al. Combined chemotherapy and
- radiotherapy compared with radiotherapy alone in patients with cancer
- of the esophagus. N Eng J Med 1992; 326: 1593-8.
- Boset JF, Gignoux M, Triboulet JP, et al. Chemoradiatherapy followed by
- surgery compared with surgery alone in squamous cell cancer of the
- esophagus. N Eng J Med 1997; 337: 161-7.
- Gebski V, Burmeister B, Smithers BM, et al. Survival benefits from
- neoadjuvant chemoradiotherapy or chemotherapy in esophageal
- carcinoma: a meta-analysis. Lancet Oncol 2007;8:226–34. doi:10.1016/
- S1470-2045(07)70039-6
- Greer SE, Goodney PP, Sutton JE, et al. Neoadjuvant chemoradiotherapy
- for esophageal carcinoma: A meta-analysis. Surgery 2005; 137:172-7.
- doi:10.1016/j.surg.2004.06.033
- Fiorica F, Di Bona D, Schepis F, et al. Preoperative chemoradiotherapy for
- oesophageal cancer: A systematic review and meta-analysis. Gut 2004;
- :925-30. doi:10.1136/gut.2003.025080
- Urschel JD, Vasan H. A meta-analysis of randomized controlled trials that
- compared neoadjuvant chemoradiation and surgery to surgery alone for
- resectable esophageal cancer. Am J Surg 2003;185:538-43.
- doi:10.1016/S0002-9610(03)00066-7
- Graham AJ, Shrive FM, Ghali WA, et al. Defining the optimal
- treatment of locally advanced esophageal cancer: A systematic review
- and decision analysis. Ann Thorac Surg 2007; 83:1257-64.
- doi:10.1016/ j.athoracsur.2006.11.061
- Coia LR, Engstrom PF, Paul AR, et al. Long-term results of infusional 5-FU,
- mitomycin-C, and radiation as primary management of esophageal
- carcinoma. Int J Radiat Oncol Biol Phys 1991;20:29-36.
- doi:10.1016/0360-3016(91)90134-P
- Wong RK, Malthaner RA, Zuraw L, et al. Cancer Care Ontario Practice
- Guidelines Initiative Gastrointestinal Cancer Disease Site Group.
- Combined modality radiotherapy and chemotherapy in nonsurgical
- management of localized carcinoma of the esophagus: a practice
- guideline. Int J Radiat Oncol Biol Phys 2003; 55:930-42. .
- doi:10.1016/S0360-3016(02)04278-5
- Cooper JS, Guo MD, Herskovic A, et al. Chemoradiotherapy of locally
- advanced esophageal cancer: long-term follow-up of a prospective
- randomized trial (RTOG 85-01). Radiation Therapy Oncology Group
- JAMA. 1999; 281:1623-7.
- al-Sarraf M, Martz K, Herskovic A, et al. Progress report of combined
- chemoradiotherapy versus radiotherapy alone in patients with
- esophageal cancer: an intergroup study. J Clin Oncol 1997;15:277-84.
- Bedenne L, Michel P, Bouché O, et al. Chemoradiation followed by surgery
- compared with chemoradiation alone in squamous cancer of the
- esophagus: FFCD 9102. J Clin Oncol 2007; 25:1160-8. doi:
- 1200/JCO.2005.04.7118
- Walsh TN, Noonan N, Hollywood D, et al. A comparison of multimodal
- therapy and surgery for esophageal adenocarcinoma. N Engl J Med 1996;
- :462-7. doi: 10.1056/NEJM199608153350702
- Urba SG, Orringer MB, Turrisi A, et al. Randomized trial of preoperative
- chemoradiation versus surgery alone in patients with locoregional
- esophageal carcinoma. J Clin Oncol 2001;19:305-13.
- Burmeister BH, Smithers BM, Gebski V, et al. Surgery alone versus
- chemoradiotherapy followed by surgery for resectable cancer of the
- oesophagus: A randomised controlled phase III trial. Lancet Oncol
- ;6:659-68. doi:10.1016/S1470-2045(05)70288-6
- Tepper J, Krasna MJ, Niedzwiecki D, et al. Phase III trial of trimodality
- therapy with cisplatin, fluorouracil, radiotherapy, and surgery compared
- with surgery alone for esophageal cancer: CALGB 9781. J Clin Oncol
- ;26:1086-92. Doi: 10.1200/JCO.2007.12.9593
- Minsky BD, Pajak TF, Ginsberg RJ, et al. INT 0123 (Radiation Therapy
- Oncology Group 94-05) phase III trial of combined-modality therapy for
- esophageal cancer: high-dose versus standard-dose radiation therapy. J
- Clin Oncol 2002;20:1167-74.
- Common Toxicity Criteria v.3.0. http://www.eortc.be/services/
- doc/ctc/default.htm. Erişim tarihi 16.09.2011
Yıl 2012,
Cilt: 25 Sayı: 2, 74 - 77, 17.03.2015
Öz
Amaç: Bu çalışmada lokal ileri evre özefagus kanseri tanısıyla neoadjuvan/ definitif kemoradyoterapi (KRT) uygulanan hastaların sonuçlarının bildirilmesi amaçlanmıştır. Hastalar ve Yöntem: Histolojik tanısı skuamöz hücreli 10, adenokarsinom 4, adenoskuamöz karsinom 1 olan, T3N0M0 5 veya T3N1M0/T4N0M0 10, toplam 15 hasta geriye dönük olarak incelendi. Ortanca radyoterapi dozu 50 Gy (1,8-2 Gy/gün, 5 fraksiyon/hafta) olup eş zamanlı kemoterapi radyoterapinin ilk ve son hafta sisplatin ve 5-florourasil olarak uygulandı. Bulgular: Eş zamanlı kemoterapinin kesintisiz uygulanabilirlik oranı %80 idi. Medyan takip 15 ay (aralık, 3-70 ay) idi. Neoadjuvan olarak tedavi edilen beş hastadan birinde lokal progresyon, üçünde uzak metastaz izlendi. Baştan definitif KRT planlanan hastalardan üçüne (%30) evrede küçülme izlenerek cerrahi önerildi. İki yıllık lokal kontrol (LK) %22, uzak metastazsız sağkalım (UMSK) %45 ve genel sağkalım (GSK) %31 olarak saptandı. Derece III disfaji oranı %6 idi. Sonuç: Lokal ileri evre özefagus kanserinde tedavi tartışmalıdır. Cerrahi şansını elde eden hastalarda daha uzun sağkalım ve lokal kontrol bildirilirken üçlü modalite tedavilerin yapılabilirliği merkezin deneyimi ile sınırlıdır. Bu nedenle tüm hastalar bireysel olarak ve multidisipliner yaklaşım ile değerlendirilmelidir. (Marmara Üniversitesi Tıp Fakültesi Dergisi 2012;25:74-7)
Anahtar Kelimeler: Cerrahi, Lokal ileri evre, Kemoradyoterapi, Özefagus kanseri
Anahtar Kelimeler
Kaynakça
- Jemal A, Siegel R, Xu J, et al. Cancer statistics, 2010. CA Cancer J Clin
- ; 60: 277–300. doi: 10.3322/caac.20073
- Sagar PM, Gauperaa T, Suc-Ling H, et al. An audit of the treatment of the
- cancer of the oesophagus. Gut 1994; 35: 941-5.
- Daly JM, Karnell LH, Menck HR. National Cancer Data Base report on
- esophageal carcinoma. Cancer 1996; 78: 1820-8. doi: 10.1002/
- (SICI)1097-0142(19961015)78:8<1820
- Kelsen DP, Ginsberg R, Pajak TF, et al. Chemotherapy followed by surgery
- compared with surgery alone for localized esophageal cancer. N Eng J
- Med 1998; 339:1979-84.
- Herskovic A, Martz K, Al-Sarraf MV, et al. Combined chemotherapy and
- radiotherapy compared with radiotherapy alone in patients with cancer
- of the esophagus. N Eng J Med 1992; 326: 1593-8.
- Boset JF, Gignoux M, Triboulet JP, et al. Chemoradiatherapy followed by
- surgery compared with surgery alone in squamous cell cancer of the
- esophagus. N Eng J Med 1997; 337: 161-7.
- Gebski V, Burmeister B, Smithers BM, et al. Survival benefits from
- neoadjuvant chemoradiotherapy or chemotherapy in esophageal
- carcinoma: a meta-analysis. Lancet Oncol 2007;8:226–34. doi:10.1016/
- S1470-2045(07)70039-6
- Greer SE, Goodney PP, Sutton JE, et al. Neoadjuvant chemoradiotherapy
- for esophageal carcinoma: A meta-analysis. Surgery 2005; 137:172-7.
- doi:10.1016/j.surg.2004.06.033
- Fiorica F, Di Bona D, Schepis F, et al. Preoperative chemoradiotherapy for
- oesophageal cancer: A systematic review and meta-analysis. Gut 2004;
- :925-30. doi:10.1136/gut.2003.025080
- Urschel JD, Vasan H. A meta-analysis of randomized controlled trials that
- compared neoadjuvant chemoradiation and surgery to surgery alone for
- resectable esophageal cancer. Am J Surg 2003;185:538-43.
- doi:10.1016/S0002-9610(03)00066-7
- Graham AJ, Shrive FM, Ghali WA, et al. Defining the optimal
- treatment of locally advanced esophageal cancer: A systematic review
- and decision analysis. Ann Thorac Surg 2007; 83:1257-64.
- doi:10.1016/ j.athoracsur.2006.11.061
- Coia LR, Engstrom PF, Paul AR, et al. Long-term results of infusional 5-FU,
- mitomycin-C, and radiation as primary management of esophageal
- carcinoma. Int J Radiat Oncol Biol Phys 1991;20:29-36.
- doi:10.1016/0360-3016(91)90134-P
- Wong RK, Malthaner RA, Zuraw L, et al. Cancer Care Ontario Practice
- Guidelines Initiative Gastrointestinal Cancer Disease Site Group.
- Combined modality radiotherapy and chemotherapy in nonsurgical
- management of localized carcinoma of the esophagus: a practice
- guideline. Int J Radiat Oncol Biol Phys 2003; 55:930-42. .
- doi:10.1016/S0360-3016(02)04278-5
- Cooper JS, Guo MD, Herskovic A, et al. Chemoradiotherapy of locally
- advanced esophageal cancer: long-term follow-up of a prospective
- randomized trial (RTOG 85-01). Radiation Therapy Oncology Group
- JAMA. 1999; 281:1623-7.
- al-Sarraf M, Martz K, Herskovic A, et al. Progress report of combined
- chemoradiotherapy versus radiotherapy alone in patients with
- esophageal cancer: an intergroup study. J Clin Oncol 1997;15:277-84.
- Bedenne L, Michel P, Bouché O, et al. Chemoradiation followed by surgery
- compared with chemoradiation alone in squamous cancer of the
- esophagus: FFCD 9102. J Clin Oncol 2007; 25:1160-8. doi:
- 1200/JCO.2005.04.7118
- Walsh TN, Noonan N, Hollywood D, et al. A comparison of multimodal
- therapy and surgery for esophageal adenocarcinoma. N Engl J Med 1996;
- :462-7. doi: 10.1056/NEJM199608153350702
- Urba SG, Orringer MB, Turrisi A, et al. Randomized trial of preoperative
- chemoradiation versus surgery alone in patients with locoregional
- esophageal carcinoma. J Clin Oncol 2001;19:305-13.
- Burmeister BH, Smithers BM, Gebski V, et al. Surgery alone versus
- chemoradiotherapy followed by surgery for resectable cancer of the
- oesophagus: A randomised controlled phase III trial. Lancet Oncol
- ;6:659-68. doi:10.1016/S1470-2045(05)70288-6
- Tepper J, Krasna MJ, Niedzwiecki D, et al. Phase III trial of trimodality
- therapy with cisplatin, fluorouracil, radiotherapy, and surgery compared
- with surgery alone for esophageal cancer: CALGB 9781. J Clin Oncol
- ;26:1086-92. Doi: 10.1200/JCO.2007.12.9593
- Minsky BD, Pajak TF, Ginsberg RJ, et al. INT 0123 (Radiation Therapy
- Oncology Group 94-05) phase III trial of combined-modality therapy for
- esophageal cancer: high-dose versus standard-dose radiation therapy. J
- Clin Oncol 2002;20:1167-74.
- Common Toxicity Criteria v.3.0. http://www.eortc.be/services/
- doc/ctc/default.htm. Erişim tarihi 16.09.2011
Toplam 75 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | Makaleler |
| Yazarlar | |
| Yayımlanma Tarihi | 17 Mart 2015 |
| Yayımlandığı Sayı | Yıl 2012 Cilt: 25 Sayı: 2 |