Year 2011,
Volume: 24 Issue: 1, 21 - 25, 30.03.2015
Gonca Mumcu
,
Nevsun İnanç
Tulin Ergun
Haner Direskeneli
References
- 1. Direskeneli H. Behcet’s Disease: Infectious etiology, new auto-antigens and HLA-B51. Ann Rheum Dis 2001; 60:996-1002. doi:10.1136/ard.60.11.996
- 2. Direskeneli H. Autoimmunity vs autoinflammation in Behcet’s disease: do we oversimplify a complex disorder? Rheumatology 2006; 45:1461-465. doi: 10.1093/rheumatology/kel329
- 3. Sakane T, Takeno M, Suzuki N, Inaba G. Behçet's disease. N Engl J Med 1999;341:1284- 1291.
- 4. Mumcu G, Inanc N, Yavuz S, Direskeneli H. The role of infectious agents in the pathogenesis, clinical manifestations and treatment strategies in Behçet’s Disease-Review. Clin Exp Rheumatol 2007; 25(4 Suppl 45):S27-33.
- 5. Mumcu G. Behçet’s disease: a dentist’s overview . Clin Exp Rheumatol 2008;26(4 Suppl 50):S121-124.
- 6. Kaneko F, Oyama N, Yanagihori H, Isogai E, Yokota K, Oguma K. The role of streptococcal hypersensitivity in the pathogenesis of Behçet’s disease. Eur J Dermatol 2008; 18: 489-498.
- 7. Yoshikawa K, Kotake S, Sasamoto Y, Ohno S, Matsuda H. Close association of Streptococcus sanguis and Behcet’s Disease. Nippon Ganka Gakkai Zasshi 1991; 95: 1261-1267.
- 8. Mizushima Y. Behçet’s Disease Research Committe of Japan, Skin hypersensitivity of streptococal antigens and the induction of systemic symptoms by the antigens in Behçet disease. J Rheumatol 1989;16:506-511.
- 9. Isogai E, Isogai H, Kotake S, Ohno S, Kimura K, Oguma K. Role of Streptococcus Sanguis and traumatic factors in Behcet’s disease. J Appl Res 2003;3:64-75.
- 10. Kaneko F, Oyama N, Nishibu A. Streptococcal infection in the pathogenesis of Behçet’s Disease and clinical effects of minocycline on the disease symptoms. Yonsei Med J 1997; 38; 444-454.
- 11. Mumcu G, Ergun T, Elbir Y, Eksioglu-Demiralp E. Clinical and immunological effects of azithromycin in Behcet's disease. J Oral Pathol Med 2005;34:13-16. Article first published online: 16 DEC 2004 doi: 10.1111/j.1600- 0714.2004.00265.x
- 12. Calguneri M, Ertenli I, Kiraz S, Erman M, Celik I. Effect of prophylactic benzathine penicilline on mucocutaneous symptoms of Behçet’s Disease. Dermatology 1996; 192: 125-128. doi:10.1159/000246336
- 13. Mumcu G, Ergun T, Inanç N, et al. Oral health is impaired in Behçet’s disease and associate with disease severity. Rheumatol 2004; 43: 1028- 1033. doi: 10.1093/rheumatology/keh236
- 14. Karacayli U, Mumcu G, Simsek I, et al. The close association between dental and periodontal treatments and oral ulcer course in Behcet's disease: a prospective clinical study. J Oral Pathol Med 2009;38:410-415. doi:10.1111/j.1600-0714.2009.00765.x
- 15. Mumcu G, Niazi S, Stewart J, Hagi-Pavli E, Gokani B, Seoudi N, Ergun T, Yavuz S, Stanford M, Fortune F, Direskeneli H: Oral health and related quality of life status in patients from UK and Turkey: A comparative study in Behcet's disease. J Oral Pathol Med. 2009;38:406-9. doi: 10.1111/j.1600-0714.2009.00752.x
- 16. Mumcu G, Ergun T. Behçet Hastalığında Oral Sağlık ve Hastalığın Gelişimindeki Yeri. TURKDERM 2009;43 (Ek: 2): 39-41.
- 17. Akman A, Ekinci NC, Kacaroglu H, Yavuzer U, Alpsoy E, Yegin O: Relationship between periodontal findings and specific polymorphisims of interleukin-1 alpha and -1 beta in Turkish patients with Behçet’s disease. Arch Dermatol Res 2008;300:19-26. doi:10.1007/s00403-007- 0794-1
- 18. Akman A, Sallakci N, Kacaroglu H, et al. Relationship between periodontal findings and the TNF-alpha Gene 1031T/C polymorphism in Turkish patients with Behçet's disease. J Eur Acad Dermatol Venereol 2008;22:950-957. Article first published online: 19 MAR 2008 doi: 10.1111/j.1468-3083.2008.02678.x
- 19. Celenligil-Nazliel H, Kansu E, Ebersole J. Periodontal findings and systemic antibody responses to oral microorganisms in Behçet’s disease. J Periodontol 1999;70: 1449-1456. doi:10.1902/jop.1999.70.12.1449
- 20. International Study Group for Behcet’s disease. Criteria for diagnosis. of Behc et’s disease. Lancet 1990;335:1078–1080.
- 21. Wilkins E. Clinical practice of the dental hygienist: Indices and scoring methods, 8th edn. Philadelphia: Lippincott Williams & Wilkins, 1999:293–314.
- 22. Krause I, Mader R, Sulkes J, et al. Behçet’s Disease in Israel: The influence of ethnic origin on disease expression and severity. J Rheumatol 2001;28: 1033-1036.
- 23. Cotti E, Dessi C, Piras A, Mercuro G. Can a chronic dental infection to be considered a cause of cardiovascular disease?: A review of the litrature. Int J Cardiol 2010, doi:10.1016/j.jcard.2010.08.011 (Epub ahead of print)
- 24. Scannapieco FA, Ho AW. Potential associations between chronic respiratory disease and periodontal disease: Analysis of National Health and Nutrition Examination Survey III. J Periodontol 2001;72:50-6. doi:10.1902/jop.2001.72.1.50
- 25. Tunes RS, Foss-freitas MC, Nogueira-filho GR. Impact of periodontitis on the diabetes-related inflammatory status. J Can Dent Assoc 2010;76:a35.
- 26. Isogai E, Ohno S, Kotake S, Isogai H, Tsurumizu T, Fuji N, Yokota K, Syuto B, Yamaguchi M, Matsuda H, Oguma K: Chemiluminescence of neutrophils from patients with Behçet’s disease and its correlation with an increased proportion of uncommon serotypes of Streptococcus sanguis in the oral flora. Archives Oral Biol 1990;35:43-48.
- 27. Mumcu G, Inanc N, Aydin SZ, Ergun T, Direskeneli H: Association of salivary S.mutans colonisation and manoose-binding lectin deficiency with gender in Behcet's disease. Clin Exp Rheumatol 2009;27(Suppl 53): S32-S36.
- 28. Yavuz S, Elbir Y, Tulunay A, Eksioglu-Demiralp E, Direskeneli H: Differential expression of tolllike receptor 6 on granulocytes and monocytes implicates the role of microorganisms in Behcet's disease etiopathogenesis. Rheumatol Int 2008;28:401-406 doi: 10.1007/s00296-007- 0470-y
- 29. Cuchacovich M, Merino G, Yamamoto JH, et al.: Behçet’s disease patients present high levels of deglycosylated anti-lipoteikoic acid IgG and high IL-8 production after lipoteikoic acid stimulation. Clin Exp Rheumatol 2005;23 (Suppl.38):S27- S34.
- 30. Direskeneli H, Direskeneli G:. The role of heat shock proteins in Behçet's disease. Clin Exp Rheumatol 2003;21(4 Suppl 30):S44-48.
- 31. Saçlı S, Seyahi E, Özyazgan Y, Mat C, Yazıcı H. Some Manifestations Disappear Earlier than Others in Behçet’s Syndrome. 14th International Conference on Behçet Disease, 8th-10th July 2010, London, United Kingdom.
Behçet Hastalarında Oral Sağlığın Değişimi: 10 Yıllık İzlem Çalışması
Year 2011,
Volume: 24 Issue: 1, 21 - 25, 30.03.2015
Gonca Mumcu
,
Nevsun İnanç
Tulin Ergun
Haner Direskeneli
Abstract
Giriş: Bu araştırmanın amacı Behçet hastalarında (BH)
10 yıllık dönemde oral sağlıktaki değişimleri
incelemektir.
Hastalar ve Yöntemler: Bu retrospektif araştırmaya 10
yıl süresince düzenli olarak klinik, laboratuvar ve oral
sağlık değerlendirmeleri yapılan 18 BH’lı hasta seçildi
(K/E: 12/6, yaş ort.:36.4 ± 9.9 yıl). Oral sağlık dental ve
periodontal indeksler ile değerlendirildi. Hastalara her
muayenede düzenli olarak oral hijyen eğitimi verildi. Oral
ülser sayısı/ay kaydedildi ve hastalık şiddet skoru
hesaplandı.
Bulgular: Diş fırçalama sıklığının 10 yıllık izlem
sonrasında (median:1.2) başlangıç dönemine
(median:1) göre artış gösterdiği ama anlamlı farklılığa
ulaşmadığı görüldü (p=0.06). Başlangıç ve kontrol
dönemlerinde dental ve periodontal indeks skorlarında
anlamlı farklılık tespit edilmedi (p>0.05). Aylık oral ülser
sayısı ise 10 yıllık izlem döneminde (median:1)
başlangıç dönemine göre (median:6) anlamlı olarak
azaldı (p=0.000).
Sonuçlar: Behçet hastalarında ağrılı ülser varlığının
oral sağlığı olumsuz yönde etkilemesine rağmen, 10
yıllık izlem döneminde oral hijyen eğitimi ve motivasyon
ile dental ve periodontal sağlığın stabil kaldığı belirlendi.
Ancak oral hijyenin iyileştirilmesi ile oral ülserin azalması
arasındaki ilişkinin daha iyi değerlendirilebilmesi için
yeni çalışmalara ihtiyaç vardır.
References
- 1. Direskeneli H. Behcet’s Disease: Infectious etiology, new auto-antigens and HLA-B51. Ann Rheum Dis 2001; 60:996-1002. doi:10.1136/ard.60.11.996
- 2. Direskeneli H. Autoimmunity vs autoinflammation in Behcet’s disease: do we oversimplify a complex disorder? Rheumatology 2006; 45:1461-465. doi: 10.1093/rheumatology/kel329
- 3. Sakane T, Takeno M, Suzuki N, Inaba G. Behçet's disease. N Engl J Med 1999;341:1284- 1291.
- 4. Mumcu G, Inanc N, Yavuz S, Direskeneli H. The role of infectious agents in the pathogenesis, clinical manifestations and treatment strategies in Behçet’s Disease-Review. Clin Exp Rheumatol 2007; 25(4 Suppl 45):S27-33.
- 5. Mumcu G. Behçet’s disease: a dentist’s overview . Clin Exp Rheumatol 2008;26(4 Suppl 50):S121-124.
- 6. Kaneko F, Oyama N, Yanagihori H, Isogai E, Yokota K, Oguma K. The role of streptococcal hypersensitivity in the pathogenesis of Behçet’s disease. Eur J Dermatol 2008; 18: 489-498.
- 7. Yoshikawa K, Kotake S, Sasamoto Y, Ohno S, Matsuda H. Close association of Streptococcus sanguis and Behcet’s Disease. Nippon Ganka Gakkai Zasshi 1991; 95: 1261-1267.
- 8. Mizushima Y. Behçet’s Disease Research Committe of Japan, Skin hypersensitivity of streptococal antigens and the induction of systemic symptoms by the antigens in Behçet disease. J Rheumatol 1989;16:506-511.
- 9. Isogai E, Isogai H, Kotake S, Ohno S, Kimura K, Oguma K. Role of Streptococcus Sanguis and traumatic factors in Behcet’s disease. J Appl Res 2003;3:64-75.
- 10. Kaneko F, Oyama N, Nishibu A. Streptococcal infection in the pathogenesis of Behçet’s Disease and clinical effects of minocycline on the disease symptoms. Yonsei Med J 1997; 38; 444-454.
- 11. Mumcu G, Ergun T, Elbir Y, Eksioglu-Demiralp E. Clinical and immunological effects of azithromycin in Behcet's disease. J Oral Pathol Med 2005;34:13-16. Article first published online: 16 DEC 2004 doi: 10.1111/j.1600- 0714.2004.00265.x
- 12. Calguneri M, Ertenli I, Kiraz S, Erman M, Celik I. Effect of prophylactic benzathine penicilline on mucocutaneous symptoms of Behçet’s Disease. Dermatology 1996; 192: 125-128. doi:10.1159/000246336
- 13. Mumcu G, Ergun T, Inanç N, et al. Oral health is impaired in Behçet’s disease and associate with disease severity. Rheumatol 2004; 43: 1028- 1033. doi: 10.1093/rheumatology/keh236
- 14. Karacayli U, Mumcu G, Simsek I, et al. The close association between dental and periodontal treatments and oral ulcer course in Behcet's disease: a prospective clinical study. J Oral Pathol Med 2009;38:410-415. doi:10.1111/j.1600-0714.2009.00765.x
- 15. Mumcu G, Niazi S, Stewart J, Hagi-Pavli E, Gokani B, Seoudi N, Ergun T, Yavuz S, Stanford M, Fortune F, Direskeneli H: Oral health and related quality of life status in patients from UK and Turkey: A comparative study in Behcet's disease. J Oral Pathol Med. 2009;38:406-9. doi: 10.1111/j.1600-0714.2009.00752.x
- 16. Mumcu G, Ergun T. Behçet Hastalığında Oral Sağlık ve Hastalığın Gelişimindeki Yeri. TURKDERM 2009;43 (Ek: 2): 39-41.
- 17. Akman A, Ekinci NC, Kacaroglu H, Yavuzer U, Alpsoy E, Yegin O: Relationship between periodontal findings and specific polymorphisims of interleukin-1 alpha and -1 beta in Turkish patients with Behçet’s disease. Arch Dermatol Res 2008;300:19-26. doi:10.1007/s00403-007- 0794-1
- 18. Akman A, Sallakci N, Kacaroglu H, et al. Relationship between periodontal findings and the TNF-alpha Gene 1031T/C polymorphism in Turkish patients with Behçet's disease. J Eur Acad Dermatol Venereol 2008;22:950-957. Article first published online: 19 MAR 2008 doi: 10.1111/j.1468-3083.2008.02678.x
- 19. Celenligil-Nazliel H, Kansu E, Ebersole J. Periodontal findings and systemic antibody responses to oral microorganisms in Behçet’s disease. J Periodontol 1999;70: 1449-1456. doi:10.1902/jop.1999.70.12.1449
- 20. International Study Group for Behcet’s disease. Criteria for diagnosis. of Behc et’s disease. Lancet 1990;335:1078–1080.
- 21. Wilkins E. Clinical practice of the dental hygienist: Indices and scoring methods, 8th edn. Philadelphia: Lippincott Williams & Wilkins, 1999:293–314.
- 22. Krause I, Mader R, Sulkes J, et al. Behçet’s Disease in Israel: The influence of ethnic origin on disease expression and severity. J Rheumatol 2001;28: 1033-1036.
- 23. Cotti E, Dessi C, Piras A, Mercuro G. Can a chronic dental infection to be considered a cause of cardiovascular disease?: A review of the litrature. Int J Cardiol 2010, doi:10.1016/j.jcard.2010.08.011 (Epub ahead of print)
- 24. Scannapieco FA, Ho AW. Potential associations between chronic respiratory disease and periodontal disease: Analysis of National Health and Nutrition Examination Survey III. J Periodontol 2001;72:50-6. doi:10.1902/jop.2001.72.1.50
- 25. Tunes RS, Foss-freitas MC, Nogueira-filho GR. Impact of periodontitis on the diabetes-related inflammatory status. J Can Dent Assoc 2010;76:a35.
- 26. Isogai E, Ohno S, Kotake S, Isogai H, Tsurumizu T, Fuji N, Yokota K, Syuto B, Yamaguchi M, Matsuda H, Oguma K: Chemiluminescence of neutrophils from patients with Behçet’s disease and its correlation with an increased proportion of uncommon serotypes of Streptococcus sanguis in the oral flora. Archives Oral Biol 1990;35:43-48.
- 27. Mumcu G, Inanc N, Aydin SZ, Ergun T, Direskeneli H: Association of salivary S.mutans colonisation and manoose-binding lectin deficiency with gender in Behcet's disease. Clin Exp Rheumatol 2009;27(Suppl 53): S32-S36.
- 28. Yavuz S, Elbir Y, Tulunay A, Eksioglu-Demiralp E, Direskeneli H: Differential expression of tolllike receptor 6 on granulocytes and monocytes implicates the role of microorganisms in Behcet's disease etiopathogenesis. Rheumatol Int 2008;28:401-406 doi: 10.1007/s00296-007- 0470-y
- 29. Cuchacovich M, Merino G, Yamamoto JH, et al.: Behçet’s disease patients present high levels of deglycosylated anti-lipoteikoic acid IgG and high IL-8 production after lipoteikoic acid stimulation. Clin Exp Rheumatol 2005;23 (Suppl.38):S27- S34.
- 30. Direskeneli H, Direskeneli G:. The role of heat shock proteins in Behçet's disease. Clin Exp Rheumatol 2003;21(4 Suppl 30):S44-48.
- 31. Saçlı S, Seyahi E, Özyazgan Y, Mat C, Yazıcı H. Some Manifestations Disappear Earlier than Others in Behçet’s Syndrome. 14th International Conference on Behçet Disease, 8th-10th July 2010, London, United Kingdom.