Graves Hastalığı Tedavisinde Sabit 10 mCi ve 15 mCi İyot-131 Dozlarının Karşılaştırılması: 11 Yıllık Tecrübe

Yıl 2011, Cilt: 24 Sayı: 1, 26 - 30, 30.03.2015

Fuat Dede Tunç Öneş Sinem Candemir Fuad Novruzov Serkan Güngör Mustafa Aras Salih Özgüven Sabahat İnanır Tanju Erdil Halil Turoğlu

Öz

Amaç: Sabit doz Iyot-131 (RAI) tedavisi, karmaşık hesaplamalara ihtiyaç duymayan basit ancak etkin bir seçenektir. Bu çalışmada, Graves hastalığında sabit 10 ve 15 mCi ile RAI tedavisi sonuçları karşılaştırıldı. Hastalar ve Yöntem: 1997-2008 tarihleri arasında sabit 10 mCi (n:48) ve sabit 15 mCi (n:9) RAI tedavisi almış ve en az 2 yıl takip edilmiş 55 hastanın takip dosyaları incelenerek başarılı (ötiroidi, hipotiroidi) ve başarısız (persiste hipertiroidi) tedavi oranları ile sonuçlara etkili olabilecek parametreler analiz edildi. Bulgular: 10 mCi alan grupta tedavi başarı oranı %87 (ötiroidi %9.1, hipotiroidi %78.2) olarak bulunurken, 15 mCi alan grupta bu değer %100 (hipotiroidi) olarak bulundu. Her iki grup arasında, kullanılan ortalama propylthiouracil dozu dışında (10 mCi: 190 mg, 15 mCi: 350 mg, p<0.05) anlamlı fark izlenmedi. Sonuç: Sabit 10 ve 15 mCi RAI doz uygulamalarının her ikisi de Graves hastalığının tedavisinde başarılı sonuç vermiştir. Sabit 10 mCi verilen hastalarda düşük oranda da olsa persistan hipertiroidizm izlenebilmektedir

Anahtar Kelimeler: Graves hastalığı, Tedavi, Sabit doz, Iyot-131

Anahtar Kelimeler

Graves hastalığı, Tedavi, Sabit doz, Iyot-131

Kaynakça

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