Öz
ÖZET Primer splenik anjiosarkomalar dalağın hematopoetik sistemle ilişkili olmayan en sık malign tümörleri olmasına karşın oldukça nadir görülmekte ve prognozu son derece kötüdür. Bu tümörlerin seyri oldukça agresif ve ölümcül olup yaygın metastazlar veya dalak rüptürü ile karşımıza çıkarlar. Kesin tanı ve tedavi cerrahi ile olur ve rüptür öncesi uygulanan splenektomi yaşam süresini anlamlı şekilde uzatır. Primer splenik anjiosarkomalı bir hastanın tanı, radyolojik patolojik bulgular ve tedavisini sunuyoruz.
Anahtar Kelimeler: Anjiosarkoma, Dalak, İmmünhistokimya, Görüntüleme
Anahtar Kelimeler
Kaynakça
- Wick MR, Scheithaver BW, Smith SI. Primary
- nonlymphoreticular malignant neoplasms of spleen.
- Am J Surg Pathol 1982; 6:229-242.
- Rosai J. Spleen. In: Rosai J. Ed. Rosai and
- Ackerman’s Surgical Pathology. Volume 2. 9th ed.
- Philadelphia: Mosby, 2004;:2036-2042.
- Cotran RS, Kumar V, Robbins S Pathologic basis of
- disease.5th ed. Philadelphia: W.B.Saunders, 1994:
- -516.
- Falk S, Krishan J, Meis JM. Primary angiosarcoma of
- spleen: A clinicopathologic study of 40 cases. Am J
- Surg Pathol 1993; 17:959-970.
- Autry JR, Weitzner S. Hemangiosarcoma of spleen
- with spontaneous rupture. Cancer 1975; 35:534-539.
- Smith VC, Usaf MC, Eisenberg BL, et al. Primary
- splenic angiosarcoma. Cancer 1985; 55:1625-1627.
- Karakas HM, Demir M, Ozyılmaz F, Cakır B.
- Primary angiosarcoma of spleen: in vivo and in vitro
- MRI findings. Clin Imaging 2001; 25:192-196.
- Wafula JM. Ultrasound and CT demonstration of
- primary angiosarcoma of spleen. Br J Radiol 1985;
- :903-907.
- Karakaş HM., Tunçbilek N, Ökten ÖÖ. Splenic
- abnormalities; an overview on sectional images.
- Diagn Intervent Radiol 2005; 11:152-58.
- Neuhauser TS, Derringer CA, Thompson LD, et.al.
- Splenic angiosarcoma: A clinicopathologic and
- immunophenotypic study of 28 cases. Mod Pathol
- ; 13:978-987.
Öz
Although primary splenic angiosarcomas are the most common malignant nonhematopoietic tumors of the spleen ,they are extremely rare tumors with very poor prognosis. These tumors are highly aggressive and lethal, present with widespread metastasis or splenic rupture. Definitive diagnosis and treatment is surgical and survival is significantly improved when splenectomy is performed prior to rupture. Diagnosis, radiologic and pathologic findings and treatment of a patient with primary splenic angiosarcoma are presented.
Anahtar Kelimeler
Kaynakça
- Wick MR, Scheithaver BW, Smith SI. Primary
- nonlymphoreticular malignant neoplasms of spleen.
- Am J Surg Pathol 1982; 6:229-242.
- Rosai J. Spleen. In: Rosai J. Ed. Rosai and
- Ackerman’s Surgical Pathology. Volume 2. 9th ed.
- Philadelphia: Mosby, 2004;:2036-2042.
- Cotran RS, Kumar V, Robbins S Pathologic basis of
- disease.5th ed. Philadelphia: W.B.Saunders, 1994:
- -516.
- Falk S, Krishan J, Meis JM. Primary angiosarcoma of
- spleen: A clinicopathologic study of 40 cases. Am J
- Surg Pathol 1993; 17:959-970.
- Autry JR, Weitzner S. Hemangiosarcoma of spleen
- with spontaneous rupture. Cancer 1975; 35:534-539.
- Smith VC, Usaf MC, Eisenberg BL, et al. Primary
- splenic angiosarcoma. Cancer 1985; 55:1625-1627.
- Karakas HM, Demir M, Ozyılmaz F, Cakır B.
- Primary angiosarcoma of spleen: in vivo and in vitro
- MRI findings. Clin Imaging 2001; 25:192-196.
- Wafula JM. Ultrasound and CT demonstration of
- primary angiosarcoma of spleen. Br J Radiol 1985;
- :903-907.
- Karakaş HM., Tunçbilek N, Ökten ÖÖ. Splenic
- abnormalities; an overview on sectional images.
- Diagn Intervent Radiol 2005; 11:152-58.
- Neuhauser TS, Derringer CA, Thompson LD, et.al.
- Splenic angiosarcoma: A clinicopathologic and
- immunophenotypic study of 28 cases. Mod Pathol
- ; 13:978-987.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Klinik Tıp Bilimleri |
| Bölüm | Olgu Sunumu |
| Yazarlar | |
| Yayımlanma Tarihi | 4 Mayıs 2015 |
| Yayımlandığı Sayı | Yıl 2009 Cilt: 22 Sayı: 1 |