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Yıl 2009, Cilt: 22 Sayı: 2, 169 - 178, 18.06.2015

Muhsin Eraslan Ebru Toker

Öz

-

Anahtar Kelimeler

-

Kaynakça

  • 1. Kim WJ, Mohan RR, Wilson SE. Effect of PDGF, IL-1alpha, and BMP2/4 on corneal fibroblast chemotaxis: expression of the platelet-derived growth factor system in the cornea. Invest Ophthalmol Vis Sci 1999; 40: 1364-72
  • 2. Tuominen IS, Tervo TM, Teppo AM, Valle TU, Grönhagen-Riska C, Vesaluoma MH. Human tear fluid PDGF-BB, TNF-alpha and TGF-beta1 vs corneal haze and regeneration of corneal epithelium and subbasal nerve plexus after PRK. Exp Eye Res 2001; 72: 631-41.
  • 3. Wilson SE,Weng J, Li Q, Vital M, Chwang EL. Epithelial injury induces keratocyte apoptosis: hypothesized role for the interleukin-1 system in the modulation of corneal tissue organization. Exp Eye Res 1996; 62: 325–338.
  • 4. Mohan RR, Kim W-J, Chen L, Wilson SE. Bone morphogenicproteins 2 and 4 and their receptors in the adult human cornea. Invest Ophthalmol Vis Sci 1998; 39: 2626–2636.
  • 5. Mohan RR, Kim WJ, Wilson SE. Modulation of TNF-alpha-induced apoptosis in corneal fibroblasts by transcription factor NF-kb. Invest Ophthalmol Vis Sci 2000; 41: 1327–1336.
  • 6. Wilson SE, Schultz GS, Chegini N, Weng J, He YG.. Epidermal growth factor, transforming growth factor alpha, transforming growth factor beta, acidic fibroblast growth factor, basic fibroblast growth factor, and interleukin-1 proteins in the cornea. Exp Eye Res1994; 59: 63–72.
  • 7. Weng J, Mohan RR, Li Q, Wilson S E. IL-1 upregulates keratinocyte growth factor and hepatocyte growth factor mRNA and protein production by cultured stromal fibroblast cells: Interleukin-1 beta expression in the cornea. Cornea 1996; 16: 465–471.
  • 8. Wilson SE, Lloyd S A , He YG.. Glucocorticoid receptor and interleukin-1 receptor messenger RNA expression in corneal cells. Cornea 1994; 13: 4–8.
  • 9. Jester J V, Petroll W M, Cavanagh H D. Corneal stromal wound healing in refractive surgery: the role of myofibroblasts. Prog Retin Eye Res 1999; 18: 311– 356.
  • 10. Strissel KJ, Rinehart WB, Fini M E. Regulation of paracrine cytokine balance controlling collagenase synthesis by corneal cells. Invest Ophthalmol Vis Sci 1997; 38: 546–552.
  • 11. West-Mays JA, Strissel KJ, Sadow PM, Fini M E. Competence for collagenase gene expression by tissue fibroblasts requires activation of an interleukin 1 alpha autocrine loop. Proc Natl Acad Sci (U S A) 1995; 92: 6768–6772.
  • 12. Pflugfelder SC, Jones D, Ji Z, Afonso A, Monroy D. Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjogren’s syndrome keratoconjunctivitis sicca. Curr Eye Res 1999; 19: 201–211.
  • 13. Mohan RR, Liang Q, Kim WJ, Helena MC, Baerveldt F, Wilson S E. Apoptosis in the cornea: further characterization of Fas/Fas ligand system. Exp Eye Res 1997; 65: 575–589.
  • 14. Wilson SE, He Y-G, Weng J, Zieske JD, Jester J V, Schultz GS. Effect of epidermal growth factor, hepatocyte growth factor, and keratinocyte growth factor, on proliferation, motility, and differentiation of human corneal epithelial cells. Exp Eye Res 1994; 59: 665–678.
  • 15. Zengin N, Koz M, Gonul B. Büyüme faktörleri: Kornea hastalıklarının tedavisinde yeni ufuklar. T Oft Gaz 1991; 21:543-548.
  • 16. Tran MT, Tellaetxe-Isusi M, Elner V, Strieter RM, Lausch RN, Oakes JE. Proinflammatory cytokines induce RANTES and MCP-1 synthesis in human corneal keratocytes but not in corneal epithelial cells. Beta-chemokine synthesis in corneal cells. Invest. Ophthalmol. Vis. Sci 1996; 37: 987–996.
  • 17. Kamiyama K, Iguchi I, Wang X, Imanishi J. Effects of PDGF on the migration of rabbit corneal fibroblasts and epithelial cells. Cornea 1998 ; 17: 315–325.
  • 18. Kim WJ, Helena MC, Mohan RR, Wilson SE. Changes in corneal morphology associated with chronic epithelial injury. Invest Ophthalmol Vis Sci 1999; 40: 35–42.
  • 19. Kim W-J, Mohan RR, Wilson SE. Effect of PDGF, IL-1 alpha, and BMP 2/4 on corneal fibroblast chemotaxis: expression of the platelet derived growth factor system in the cornea. Invest Ophthalmol Vis Sci 1999; 40: 1364–1372.
  • 20. Helena MC, Baerveldt F, Kim W-J, Wilson SE. Keratocyte apoptosis after corneal surgery. Invest Ophthalmol Vis Sci 1998 ;39: 276–283.
  • 21. Wilson SE, Pedroza L, Beuerman R, Hill JM. Herpes simplex virus type-1 infection of corneal epithelial cells induces apoptosis of the underlying keratocytes. Exp Eye Res 1997; 64: 775–779.
  • 22. Mohan RR, Wilson SE. Discoidin domain receptor (DDR) 1 and 2: collagenactivated tyrosine kinase receptors in the cornea. Exp Eye Res 2001; 72: 87– 92.
  • 23. Watsky MA. Keratocyte gap junctional communication in normal and wounded rabbit corneas and human corneas. Invest Ophthalmol Vis Sci 1995; 36: 2568–2576.
  • 24. Wilson SE, Liang Q, Kim W-J. Lacrimal gland HGF, KGF, and EGF mRNA levels increase after corneal epithelial wounding. Invest Ophthalmol Vis Sci 1999 ; 40: 2185–2190.
  • 25. Wilson SE. Lacrimal gland epidermal growth factor production and the ocular surface.Am J Ophthalmol 1991; 111: 763-765.
  • 26. Thoft RA, Friend J. The X, Y, Z hypothesis of corneal epithelial maintenance. Invest Ophthalmol Vis Sci 1983; 24:1442-1443.
  • 27. Wilson SE, Mohan RR, Ambrosio R, Hong J, Lee J. The corneal wound healing response: cytokinemediated interaction of the epithelium, stroma, and inflammatory cells. Prog Retin Eye Res 2001; 20: 625-637.
  • 28. Fini ME. Keratocyte and fibroblast phenotypes in the repairing cornea.Prog Retin Eye Res 1999;18:529–551.
  • 29. Clark RA. Potential roles of fibronectin in cutaneous wound repair.Arch Dermatol. 1988;124:201-206.
  • 30. Cintron C, Hassinger LC, Kublin CL, Cannon DJ. Biochemical and ultrastructural changes in collagen during corneal wound healing. J Ultrastruct Res 1978; 65: 13-22.
  • 31. Brown SI, Weller CA. Cell origin of collagenase in normal and wounded corneas. Arch Ophthalmol 1970; 83: 74-77.
  • 32. Porras-Reyes BH, Blair HC, Jeffrey JJ, Mustoe TA. Collagenase production at the border of granulation tissue in a healing wound: macrophage and mesenchymal collagenase production in vivo. Connect Tissue Res 1991;27:63-71.
  • 33. Hembry RM, Bernanke DH, Hayashi K, Trelstad RL, Ehrlich HP. Morphologic examination of mesenchymal cells in healing wounds of normal and tight skin mice.Am J Pathol 1986;125:81-89.
  • 34. Werb Z, Alexander CM, Adler RR. Expression and function of matrix metalloproteinases in development.Matrix Suppl 1992;1:337-343.
  • 35. Cintron C, Covington HI, Kublin CL. Morphologic analyses of proteoglycans in rabbit corneal scars. Invest Ophthalmol Vis Sci 1990; 31: 1789–1798.
  • 36. Mohan RR, Hutcheon AEK, Choi R. Apoptosis, necrosis, proliferation, and myofibroblast generation in the stroma following LASIK and PRK. Exp Eye Res 2003; 76:71–87.
  • 37. Wilson SE. Activation of keratocyte apoptosis in response to epithelial scrape injury does not require tears [letter]. Invest Ophthalmol Vis Sci 2002. Available at http://www.iovs.org/cgi/eletters/42/8/1743).
  • 38. Erie JC, Nau CB, McLaren JW. Long-term keratocyte deficits in the corneal stroma after LASIK. Ophthalmology 2004;111:1356–1361.
  • 39. Kim JH, Kim MS, Hahn TW, Lee YC, Sah WJ, Park CK. Five years results of photorefractive keratectomy for myopia. J. Cataract Refract. Surg 1997; 23: 731-735.
  • 40. Lohmann CP, Guell JL. Regression after LASIK for the treatment of myopia: the role of the corneal epithelium. Semin Ophthalmol 1998;13:79-82.
  • 41. Ambrosio R Jr, Periman LM, Netto MV, Wilson SE. Bilateral marginal sterile infiltrates and diffuse lamellar keratitis after laser in situ keratomileusis.J Refract Surg 2003;19:154-158.
  • 42. Wilson SE, Ambrosio R Jr. Sporadic diffuse lamellar keratitis (DLK) after LASIK. Cornea 2002; 21: 560-563.
  • 43. Netto MV, Mohan RR, Ambrosio Jr R, Hutcheon AE, Zieske JD, Wilson SE. Wound healing in the cornea: a review of refractive surgery complications and new prospects for therapy. Cornea 2005; 24: 509-522.
  • 44. McCarey BE, Napalkov JA, Pippen PA, Koester JM, al Reaves T. Corneal wound healing strength with topical antiinflammatory drugs. Cornea 1995; 14: 290-294.
  • 45. Vigo L, Scandola E, Carones F. Scraping and mitomycin C to treat haze and regression after photorefractive keratectomy for myopia. J. Refract. Surg 2003; 19: 449-454.
  • 46. Netto MV, Mohan RR, Sinha S, Sharma A, Gupta PC, Wilson SE. Effect of prophylactic and therapeutic mitomycin C on corneal apoptosis, proliferation, haze, and keratocyte density. J Ref Surg 2006;22(6):562–274.
  • 47. Tseng SC, Li DQ, Ma X. Suppression of transforming growth factor-beta isoforms, TGFbeta receptor type II, and myofibroblast differentiation in cultured human corneal and limbal fibroblasts by amniotic membrane matrix. J Cell Physiol 1999;179:325-335.
  • 48. Tseng SC, Prabhasawat P, Barton K, Gray T, Meller D. Amniotic membrane transplantation with or without limbal allografts for corneal surface reconstruction in patients with limbal stem cell deficiency. Arch Ophthalmol 1998;116:431-441.
  • 49. Wang MX, Gray TB, Park WC, et al.: Reduction in corneal haze and apoptosis by amniotic membrane matrix in excimer laser photoablation in rabbits. J Cataract Refract Surg 2001; 27:310–319.
  • 50. Lee HK, Kim JK, Kim SS, et al.Effect of amniotic membrane after laser-assisted subepithelial keratectomy on epithelial healing: clinical and refractive outcomes. J Cataract Refract Surg 2004;30:334-340.
  • 51. Yang J, Yamato M, Nishida K, et al. Corneal epithelial stem cell delivery using cell sheet engineering: not lost in transplantation.J Drug Target 2006;14:471-482. Review. Erratum in: J Drug Target 2006;14:662.

KORNEA YARA İYİLEŞMESİNİN MEKANİZMALARI VE REFRAKTİF CERRAHİ OPERASYON SONRASI MODÜLASYONU

Yıl 2009, Cilt: 22 Sayı: 2, 169 - 178, 18.06.2015

Muhsin Eraslan Ebru Toker

Öz

ÖZET Korneanın yara iyileşme cevabı; epitel hücreleri,stromal keratositler, kornea sinirleri, lakrimal bezler, göz yaşı tabakası ve immün sistem hücreleri arasındaki sitokin aracılı etkileşimi kapsayan karmaşık bir kaskaddır. Hasarın miktarına bağlı olarak dokunun yanıtı değişir. Mesela keratorefraktif cerrahi prosedürlerde kullanılan insizyonel, lameller ve yüzey kazınmasına bağlı hasarlar birbirine bazı yönlerden benzeyen fakat diğer yönlerden farklı olan tipik cevaplara neden olurlar. Bu cevabın şiddeti cerrahi sonrasında elde edilecek başarıyı etkiler. Bu makale kornea yara iyileşme yanıtındaki hücresel etkileşimleri, sitokin düzenlemelerini özetleyecek ve keratorefraktif cerrahi operasyonları takiben bu yanıtın modülasyonuna genel bir bakış sağlayacaktır.

Anahtar Kelimeler: Kornea, Yara İyileşmesi, Refraktif, Refraktif Cerrahi, Modülasyon, Sitokin

Anahtar Kelimeler

Kornea Yara İyileşmesi Refraktif Refraktif Cerrahi Modülasyon Sitokin

Kaynakça

  • 1. Kim WJ, Mohan RR, Wilson SE. Effect of PDGF, IL-1alpha, and BMP2/4 on corneal fibroblast chemotaxis: expression of the platelet-derived growth factor system in the cornea. Invest Ophthalmol Vis Sci 1999; 40: 1364-72
  • 2. Tuominen IS, Tervo TM, Teppo AM, Valle TU, Grönhagen-Riska C, Vesaluoma MH. Human tear fluid PDGF-BB, TNF-alpha and TGF-beta1 vs corneal haze and regeneration of corneal epithelium and subbasal nerve plexus after PRK. Exp Eye Res 2001; 72: 631-41.
  • 3. Wilson SE,Weng J, Li Q, Vital M, Chwang EL. Epithelial injury induces keratocyte apoptosis: hypothesized role for the interleukin-1 system in the modulation of corneal tissue organization. Exp Eye Res 1996; 62: 325–338.
  • 4. Mohan RR, Kim W-J, Chen L, Wilson SE. Bone morphogenicproteins 2 and 4 and their receptors in the adult human cornea. Invest Ophthalmol Vis Sci 1998; 39: 2626–2636.
  • 5. Mohan RR, Kim WJ, Wilson SE. Modulation of TNF-alpha-induced apoptosis in corneal fibroblasts by transcription factor NF-kb. Invest Ophthalmol Vis Sci 2000; 41: 1327–1336.
  • 6. Wilson SE, Schultz GS, Chegini N, Weng J, He YG.. Epidermal growth factor, transforming growth factor alpha, transforming growth factor beta, acidic fibroblast growth factor, basic fibroblast growth factor, and interleukin-1 proteins in the cornea. Exp Eye Res1994; 59: 63–72.
  • 7. Weng J, Mohan RR, Li Q, Wilson S E. IL-1 upregulates keratinocyte growth factor and hepatocyte growth factor mRNA and protein production by cultured stromal fibroblast cells: Interleukin-1 beta expression in the cornea. Cornea 1996; 16: 465–471.
  • 8. Wilson SE, Lloyd S A , He YG.. Glucocorticoid receptor and interleukin-1 receptor messenger RNA expression in corneal cells. Cornea 1994; 13: 4–8.
  • 9. Jester J V, Petroll W M, Cavanagh H D. Corneal stromal wound healing in refractive surgery: the role of myofibroblasts. Prog Retin Eye Res 1999; 18: 311– 356.
  • 10. Strissel KJ, Rinehart WB, Fini M E. Regulation of paracrine cytokine balance controlling collagenase synthesis by corneal cells. Invest Ophthalmol Vis Sci 1997; 38: 546–552.
  • 11. West-Mays JA, Strissel KJ, Sadow PM, Fini M E. Competence for collagenase gene expression by tissue fibroblasts requires activation of an interleukin 1 alpha autocrine loop. Proc Natl Acad Sci (U S A) 1995; 92: 6768–6772.
  • 12. Pflugfelder SC, Jones D, Ji Z, Afonso A, Monroy D. Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjogren’s syndrome keratoconjunctivitis sicca. Curr Eye Res 1999; 19: 201–211.
  • 13. Mohan RR, Liang Q, Kim WJ, Helena MC, Baerveldt F, Wilson S E. Apoptosis in the cornea: further characterization of Fas/Fas ligand system. Exp Eye Res 1997; 65: 575–589.
  • 14. Wilson SE, He Y-G, Weng J, Zieske JD, Jester J V, Schultz GS. Effect of epidermal growth factor, hepatocyte growth factor, and keratinocyte growth factor, on proliferation, motility, and differentiation of human corneal epithelial cells. Exp Eye Res 1994; 59: 665–678.
  • 15. Zengin N, Koz M, Gonul B. Büyüme faktörleri: Kornea hastalıklarının tedavisinde yeni ufuklar. T Oft Gaz 1991; 21:543-548.
  • 16. Tran MT, Tellaetxe-Isusi M, Elner V, Strieter RM, Lausch RN, Oakes JE. Proinflammatory cytokines induce RANTES and MCP-1 synthesis in human corneal keratocytes but not in corneal epithelial cells. Beta-chemokine synthesis in corneal cells. Invest. Ophthalmol. Vis. Sci 1996; 37: 987–996.
  • 17. Kamiyama K, Iguchi I, Wang X, Imanishi J. Effects of PDGF on the migration of rabbit corneal fibroblasts and epithelial cells. Cornea 1998 ; 17: 315–325.
  • 18. Kim WJ, Helena MC, Mohan RR, Wilson SE. Changes in corneal morphology associated with chronic epithelial injury. Invest Ophthalmol Vis Sci 1999; 40: 35–42.
  • 19. Kim W-J, Mohan RR, Wilson SE. Effect of PDGF, IL-1 alpha, and BMP 2/4 on corneal fibroblast chemotaxis: expression of the platelet derived growth factor system in the cornea. Invest Ophthalmol Vis Sci 1999; 40: 1364–1372.
  • 20. Helena MC, Baerveldt F, Kim W-J, Wilson SE. Keratocyte apoptosis after corneal surgery. Invest Ophthalmol Vis Sci 1998 ;39: 276–283.
  • 21. Wilson SE, Pedroza L, Beuerman R, Hill JM. Herpes simplex virus type-1 infection of corneal epithelial cells induces apoptosis of the underlying keratocytes. Exp Eye Res 1997; 64: 775–779.
  • 22. Mohan RR, Wilson SE. Discoidin domain receptor (DDR) 1 and 2: collagenactivated tyrosine kinase receptors in the cornea. Exp Eye Res 2001; 72: 87– 92.
  • 23. Watsky MA. Keratocyte gap junctional communication in normal and wounded rabbit corneas and human corneas. Invest Ophthalmol Vis Sci 1995; 36: 2568–2576.
  • 24. Wilson SE, Liang Q, Kim W-J. Lacrimal gland HGF, KGF, and EGF mRNA levels increase after corneal epithelial wounding. Invest Ophthalmol Vis Sci 1999 ; 40: 2185–2190.
  • 25. Wilson SE. Lacrimal gland epidermal growth factor production and the ocular surface.Am J Ophthalmol 1991; 111: 763-765.
  • 26. Thoft RA, Friend J. The X, Y, Z hypothesis of corneal epithelial maintenance. Invest Ophthalmol Vis Sci 1983; 24:1442-1443.
  • 27. Wilson SE, Mohan RR, Ambrosio R, Hong J, Lee J. The corneal wound healing response: cytokinemediated interaction of the epithelium, stroma, and inflammatory cells. Prog Retin Eye Res 2001; 20: 625-637.
  • 28. Fini ME. Keratocyte and fibroblast phenotypes in the repairing cornea.Prog Retin Eye Res 1999;18:529–551.
  • 29. Clark RA. Potential roles of fibronectin in cutaneous wound repair.Arch Dermatol. 1988;124:201-206.
  • 30. Cintron C, Hassinger LC, Kublin CL, Cannon DJ. Biochemical and ultrastructural changes in collagen during corneal wound healing. J Ultrastruct Res 1978; 65: 13-22.
  • 31. Brown SI, Weller CA. Cell origin of collagenase in normal and wounded corneas. Arch Ophthalmol 1970; 83: 74-77.
  • 32. Porras-Reyes BH, Blair HC, Jeffrey JJ, Mustoe TA. Collagenase production at the border of granulation tissue in a healing wound: macrophage and mesenchymal collagenase production in vivo. Connect Tissue Res 1991;27:63-71.
  • 33. Hembry RM, Bernanke DH, Hayashi K, Trelstad RL, Ehrlich HP. Morphologic examination of mesenchymal cells in healing wounds of normal and tight skin mice.Am J Pathol 1986;125:81-89.
  • 34. Werb Z, Alexander CM, Adler RR. Expression and function of matrix metalloproteinases in development.Matrix Suppl 1992;1:337-343.
  • 35. Cintron C, Covington HI, Kublin CL. Morphologic analyses of proteoglycans in rabbit corneal scars. Invest Ophthalmol Vis Sci 1990; 31: 1789–1798.
  • 36. Mohan RR, Hutcheon AEK, Choi R. Apoptosis, necrosis, proliferation, and myofibroblast generation in the stroma following LASIK and PRK. Exp Eye Res 2003; 76:71–87.
  • 37. Wilson SE. Activation of keratocyte apoptosis in response to epithelial scrape injury does not require tears [letter]. Invest Ophthalmol Vis Sci 2002. Available at http://www.iovs.org/cgi/eletters/42/8/1743).
  • 38. Erie JC, Nau CB, McLaren JW. Long-term keratocyte deficits in the corneal stroma after LASIK. Ophthalmology 2004;111:1356–1361.
  • 39. Kim JH, Kim MS, Hahn TW, Lee YC, Sah WJ, Park CK. Five years results of photorefractive keratectomy for myopia. J. Cataract Refract. Surg 1997; 23: 731-735.
  • 40. Lohmann CP, Guell JL. Regression after LASIK for the treatment of myopia: the role of the corneal epithelium. Semin Ophthalmol 1998;13:79-82.
  • 41. Ambrosio R Jr, Periman LM, Netto MV, Wilson SE. Bilateral marginal sterile infiltrates and diffuse lamellar keratitis after laser in situ keratomileusis.J Refract Surg 2003;19:154-158.
  • 42. Wilson SE, Ambrosio R Jr. Sporadic diffuse lamellar keratitis (DLK) after LASIK. Cornea 2002; 21: 560-563.
  • 43. Netto MV, Mohan RR, Ambrosio Jr R, Hutcheon AE, Zieske JD, Wilson SE. Wound healing in the cornea: a review of refractive surgery complications and new prospects for therapy. Cornea 2005; 24: 509-522.
  • 44. McCarey BE, Napalkov JA, Pippen PA, Koester JM, al Reaves T. Corneal wound healing strength with topical antiinflammatory drugs. Cornea 1995; 14: 290-294.
  • 45. Vigo L, Scandola E, Carones F. Scraping and mitomycin C to treat haze and regression after photorefractive keratectomy for myopia. J. Refract. Surg 2003; 19: 449-454.
  • 46. Netto MV, Mohan RR, Sinha S, Sharma A, Gupta PC, Wilson SE. Effect of prophylactic and therapeutic mitomycin C on corneal apoptosis, proliferation, haze, and keratocyte density. J Ref Surg 2006;22(6):562–274.
  • 47. Tseng SC, Li DQ, Ma X. Suppression of transforming growth factor-beta isoforms, TGFbeta receptor type II, and myofibroblast differentiation in cultured human corneal and limbal fibroblasts by amniotic membrane matrix. J Cell Physiol 1999;179:325-335.
  • 48. Tseng SC, Prabhasawat P, Barton K, Gray T, Meller D. Amniotic membrane transplantation with or without limbal allografts for corneal surface reconstruction in patients with limbal stem cell deficiency. Arch Ophthalmol 1998;116:431-441.
  • 49. Wang MX, Gray TB, Park WC, et al.: Reduction in corneal haze and apoptosis by amniotic membrane matrix in excimer laser photoablation in rabbits. J Cataract Refract Surg 2001; 27:310–319.
  • 50. Lee HK, Kim JK, Kim SS, et al.Effect of amniotic membrane after laser-assisted subepithelial keratectomy on epithelial healing: clinical and refractive outcomes. J Cataract Refract Surg 2004;30:334-340.
  • 51. Yang J, Yamato M, Nishida K, et al. Corneal epithelial stem cell delivery using cell sheet engineering: not lost in transplantation.J Drug Target 2006;14:471-482. Review. Erratum in: J Drug Target 2006;14:662.
Toplam 51 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Derleme
Yazarlar

Muhsin Eraslan Bu kişi benim

Ebru Toker Bu kişi benim

Yayımlanma Tarihi 18 Haziran 2015
Yayımlandığı Sayı Yıl 2009 Cilt: 22 Sayı: 2

Kaynak Göster

APA Eraslan, M., & Toker, E. (2015). KORNEA YARA İYİLEŞMESİNİN MEKANİZMALARI VE REFRAKTİF CERRAHİ OPERASYON SONRASI MODÜLASYONU. Marmara Medical Journal, 22(2), 169-178.
AMA Eraslan M, Toker E. KORNEA YARA İYİLEŞMESİNİN MEKANİZMALARI VE REFRAKTİF CERRAHİ OPERASYON SONRASI MODÜLASYONU. Marmara Med J. Ağustos 2015;22(2):169-178.
Chicago Eraslan, Muhsin, ve Ebru Toker. “KORNEA YARA İYİLEŞMESİNİN MEKANİZMALARI VE REFRAKTİF CERRAHİ OPERASYON SONRASI MODÜLASYONU”. Marmara Medical Journal 22, sy. 2 (Ağustos 2015): 169-78.
EndNote Eraslan M, Toker E (01 Ağustos 2015) KORNEA YARA İYİLEŞMESİNİN MEKANİZMALARI VE REFRAKTİF CERRAHİ OPERASYON SONRASI MODÜLASYONU. Marmara Medical Journal 22 2 169–178.
IEEE M. Eraslan ve E. Toker, “KORNEA YARA İYİLEŞMESİNİN MEKANİZMALARI VE REFRAKTİF CERRAHİ OPERASYON SONRASI MODÜLASYONU”, Marmara Med J, c. 22, sy. 2, ss. 169–178, 2015.
ISNAD Eraslan, Muhsin - Toker, Ebru. “KORNEA YARA İYİLEŞMESİNİN MEKANİZMALARI VE REFRAKTİF CERRAHİ OPERASYON SONRASI MODÜLASYONU”. Marmara Medical Journal 22/2 (Ağustos 2015), 169-178.
JAMA Eraslan M, Toker E. KORNEA YARA İYİLEŞMESİNİN MEKANİZMALARI VE REFRAKTİF CERRAHİ OPERASYON SONRASI MODÜLASYONU. Marmara Med J. 2015;22:169–178.
MLA Eraslan, Muhsin ve Ebru Toker. “KORNEA YARA İYİLEŞMESİNİN MEKANİZMALARI VE REFRAKTİF CERRAHİ OPERASYON SONRASI MODÜLASYONU”. Marmara Medical Journal, c. 22, sy. 2, 2015, ss. 169-78.
Vancouver Eraslan M, Toker E. KORNEA YARA İYİLEŞMESİNİN MEKANİZMALARI VE REFRAKTİF CERRAHİ OPERASYON SONRASI MODÜLASYONU. Marmara Med J. 2015;22(2):169-78.