SPERM ANOMALİSİ GÖSTEREN ERKEKLERDE SİTOGENETİK ANALİZLER

Yıl 2009, Cilt: 22 Sayı: 3, 217 - 224, 19.06.2015

Ebru Önalan Etem Hüseyin Yüce Deniz Erol Şükriye Deveci Gülay Güleç Ceylan Halit Elyas

Öz

Amaç: Erkek infertilitesi çocuk sahibi olamayan çiftlerin yarısından sorumludur. Kromozomal
abnormaliteler fertil erkeklerle karşılaştırıldığında infertil erkeklerde daha sıktır. Kromozomal anomalilerin
spermotogenezde başarısızlığa neden olarak erkek infertilitesine neden olduğu bilinmektedir. Çalışmada
sperm anomalisi gösteren infertil erkeklerde major kromozomal anomalilerin tipleri ve sıklığının
araştırılması amaçlanmıştır.
Gereç ve Yöntem: Toplam 214 (138 azospermik, 76 oligospermik) infertil erkek bireye sitogenetik
inceleme yapıldı. Tüm hastaların periferik kan lenfositlerinin kromozomal analizleri sdandart yöntemlere
göre yapıldı.
Bulgular: Toplam 214 infertil erkeğin 24 (%11.2)’ünde klinifelter sendromu (16/24; %7.5), XYY sendromu
(1/24; %0.5), XX erkek sendromu (1/24; %0.5), 45,X, mar (Y) (1/24; %0.5), 46,XX, inv(Y)(p11q11) (1/24;
%0.5), 46,XY, der(1)t(1;5)(p33;qter) (1/24; %0.5), 46,XY, t(15;15) (1/24; %0.5) ve 46,XY,t(14;21) (1/24;
%0.5) kromozomal anomalileri tespit edildi.
Sonuçlar: Bu çalışma infertil erkeklerde kromozomal anomalilerin sıklığı %11.2 olduğunu göstermektedir.
Bu genetik bozuklukların yeni nesillere aktarılmasındaki potansiyel risk infertil erkeklerin ICSI’dan önce
taranması için bir sebep oluşturmaktadır. Ayrıca, genetik tarama ve danışmanın infertil hastalara rutin olarak
yapılması gerekmektedir.

Anahtar Kelimeler

İnfertilite, Kromozom, Sitogenetik, Azospermi, Oligospermi

Kaynakça

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