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Year 2004, Volume: 17 Issue: 3, 105 - 108, 29.06.2015

Gülay Kenangil A. Yalçın Gonca Haklar Hasan Cacina Hulki Forta

Abstract

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Keywords

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References

  • Martens P, Raabe A, Johnsson P. Serum S-100 and
  • neuron-specific enolase for prediction of regaining
  • consciousness after global cerebral ischemia. Stroke
  • ; 9: 2363-2366.
  • Heizmann WC. Ca-binding S-100 proteins in the central
  • nervous system. Neurochem Res 1999; 24: 1097-1100.
  • Heizmann WC, Cox JA. New perspectives on S-100
  • proteins: a multifunctional Ca+2-Zn+2 and Cu+2 binding
  • protein family. Biometals 1998; 11: 383-397.
  • Schmidt S. S-100 B: pathogenetic and pathophysiologic
  • significance in neurology. Nervenarzt 1998; 69: 639-
  • -
  • Hardemark HG, Erricson N, Kotwica Z, et al. S-100
  • protein and neuron-specific enolase in CSF after
  • experimental traumatic or focal ischemic brain damage.
  • J Neurosurg 1989; 71: 727-731.
  • Makuno K, Kato K, Kawai K, Matsuoka Y, Yanagi T,
  • Sobue I. Neuron-specific enolase and S-100 protein
  • levels in cerebrospinal fluid of patients with various
  • neurological diseases. J. Neurol Sci 1983; 60: 443-451.
  • Lamers KJ, van Engelen BG, Gabreels FJ, Hommes OR,
  • Borm GF, Wevers RA. Cerebrospinal neuron-spesific
  • enolase, S-100 and myelin basic protein in neurological
  • disorders. Acta Neurol Scand 1995; 92: 247-251.
  • Tatu L, Moulin T, Bogousslavsky J, Duvernoy H.
  • Arterial territories of the human brain, cerebral
  • hemispheres. Neurology 1998; 50: 1699-1708.
  • Butterworth RJ, Wassif WS, Sherwood RA,Gerges A.
  • Serum NSE, carnosinase, and their ratio in acute stroke:
  • an enzimatic test for predicting outcome ? Stroke 1996;
  • : 2064- 2068.
  • Engelen BG, Lamers KJ, Gabreels FJ, Wever RA, van
  • Geel WJ , Borm GF. Age-related changes of neuron
  • specific enolase, S-100 protein and myelin basic protein
  • concentration in cerebrospinal fluid. Clin Chem, 1992;
  • : 813-816.
  • Persson L, Hardemark HG, Gustafsson J et al. S-100
  • protein and neuron specific enolase in cerebrospinal
  • fluıd and serum: markers of cell damage in human
  • central nervous system. Stroke 1987; 18: 911-918.
  • Büttner T, Weyers S, Postert T. S-100 Protein: serum
  • marker of focal brain damage after ischemic territorial
  • MCA infarction. Stroke 1997; 28: 1961-1965.
  • Kim JS, Yoon SS, Kim YH,Ryu JS. Serial measurement
  • of interleukin-6, transforming growth factor-B and S-
  • protein in patients with acute stroke. Stroke 1996:
  • ; 1553-1557.
  • Herrmann M, Vos P, Wunderlich MT, Bruijn CHMM,
  • Lamers KJB. Release of glial tissue-specific proteins
  • after acute stroke. A comparative analysis of serum
  • concentrations of protein S-100 B and glial fibrillary
  • acidic protein. Stroke 2000; 31: 2670-2677.
  • Missler U, Wiesmann M, Friedrich C, Kaps M. S-100
  • Protein and neuron-specific enolase concentrations in
  • blood as indicators of infarction volume and prognosis
  • in acute ischemic stroke. Stroke 1997; 28: 1956-1960.
  • Wunderlich MT, Ebert AD, Kratz T, Goertler M, Jost S,
  • Hermann M. Early neurobehavioral outcome after stroke
  • is related to release of neurobiochemical markers of
  • brain damage. Stroke 1999; 30: 1190-1195.
  • Foerch C, Otto B, Singer O C, Haefelin T N, Yan B,
  • Berkefeld J, Steinmetz H et al. Serum S-100 B predicts a
  • malignant course of infarction in patients with acute
  • middle cerebral artery occlusion. Stroke 2004; 35: 2160-
  • -
  • Foerch C, Singer O C, Haefilin TN, Rochemont M,
  • Steinmetz H. Evaluation of Serum S-100 B as a
  • surragate marker for long-term outcome and infarct
  • volume in acute middle cerebral artery infarction. Arch
  • Neurol 2005 ;62: 1130-1134.

SERUM S-100 PROTEİNİNİN ENFARKT BOYUTU VE KLİNİK PROGNOZ İLE İLİŞKİSİ

Year 2004, Volume: 17 Issue: 3, 105 - 108, 29.06.2015

Gülay Kenangil A. Yalçın Gonca Haklar Hasan Cacina Hulki Forta

Abstract

Amaç: Akut iskemik inmelerde serum S-100 protein konsantrasyonlarının ölçülmesi ile enfarkt boyutu ve klinik prognoz ile olan korelasyonlarının belirlenmesi Yöntemler: Serum örnekleri 26 akut iskemik inmeli olgudan başvuru sırasında, 3. ve 7. günlerde toplandı. Serum S-100 protein düzeyleri Smart S-100 protein saptama reaktifi ile ölçüldü. Lezyonlar supratentoryal orta serebral arter (middle cerebral artery, MCA) enfarktları ve infratentoryal beyin sapı enfarktları olarak sınıflandırıldı. Tüm hastaların ilk 24 saat içinde çekilmiş kraniyal kompüterize tomografileri (computerized tomography, CT) ve ilk hafta içinde çekilmiş manyetik rezonans görüntülemeleri veya CT’leri mevcuttu. Nörolojik incelemeleri akut evrede “National Institute of Health Stroke Scale (NIHSS)” ile, 1. ve 6. aylarda “Modified Barthel Index (MBI)” ile yapıldı. İstatistiksel analizlerde ANOVA kullanıldı. Bulgular: MCA bölgesinin 2/3’ünden fazlasını tutan MCA enfarktları 3. günde en yüksek S-100 protein değerlerine, en yüksek NIHSS ve en düşük MBI skorlarına sahipti. İnfratentoryal enfarkt grubunda serum S-100 proteini ölçülemez düzeydeydi. Sonuç: MCA lezyonlarında S-100 proteini enfarkt boyu ve klinik prognoz ile ilişkilidir ve 3. gündeki artış ödem göstergesi olabilir.

Anahtar Kelimeler: S-100 proteini, İskemik inme, Prognoz, Enfarkt boyutu

Keywords

-

References

  • Martens P, Raabe A, Johnsson P. Serum S-100 and
  • neuron-specific enolase for prediction of regaining
  • consciousness after global cerebral ischemia. Stroke
  • ; 9: 2363-2366.
  • Heizmann WC. Ca-binding S-100 proteins in the central
  • nervous system. Neurochem Res 1999; 24: 1097-1100.
  • Heizmann WC, Cox JA. New perspectives on S-100
  • proteins: a multifunctional Ca+2-Zn+2 and Cu+2 binding
  • protein family. Biometals 1998; 11: 383-397.
  • Schmidt S. S-100 B: pathogenetic and pathophysiologic
  • significance in neurology. Nervenarzt 1998; 69: 639-
  • -
  • Hardemark HG, Erricson N, Kotwica Z, et al. S-100
  • protein and neuron-specific enolase in CSF after
  • experimental traumatic or focal ischemic brain damage.
  • J Neurosurg 1989; 71: 727-731.
  • Makuno K, Kato K, Kawai K, Matsuoka Y, Yanagi T,
  • Sobue I. Neuron-specific enolase and S-100 protein
  • levels in cerebrospinal fluid of patients with various
  • neurological diseases. J. Neurol Sci 1983; 60: 443-451.
  • Lamers KJ, van Engelen BG, Gabreels FJ, Hommes OR,
  • Borm GF, Wevers RA. Cerebrospinal neuron-spesific
  • enolase, S-100 and myelin basic protein in neurological
  • disorders. Acta Neurol Scand 1995; 92: 247-251.
  • Tatu L, Moulin T, Bogousslavsky J, Duvernoy H.
  • Arterial territories of the human brain, cerebral
  • hemispheres. Neurology 1998; 50: 1699-1708.
  • Butterworth RJ, Wassif WS, Sherwood RA,Gerges A.
  • Serum NSE, carnosinase, and their ratio in acute stroke:
  • an enzimatic test for predicting outcome ? Stroke 1996;
  • : 2064- 2068.
  • Engelen BG, Lamers KJ, Gabreels FJ, Wever RA, van
  • Geel WJ , Borm GF. Age-related changes of neuron
  • specific enolase, S-100 protein and myelin basic protein
  • concentration in cerebrospinal fluid. Clin Chem, 1992;
  • : 813-816.
  • Persson L, Hardemark HG, Gustafsson J et al. S-100
  • protein and neuron specific enolase in cerebrospinal
  • fluıd and serum: markers of cell damage in human
  • central nervous system. Stroke 1987; 18: 911-918.
  • Büttner T, Weyers S, Postert T. S-100 Protein: serum
  • marker of focal brain damage after ischemic territorial
  • MCA infarction. Stroke 1997; 28: 1961-1965.
  • Kim JS, Yoon SS, Kim YH,Ryu JS. Serial measurement
  • of interleukin-6, transforming growth factor-B and S-
  • protein in patients with acute stroke. Stroke 1996:
  • ; 1553-1557.
  • Herrmann M, Vos P, Wunderlich MT, Bruijn CHMM,
  • Lamers KJB. Release of glial tissue-specific proteins
  • after acute stroke. A comparative analysis of serum
  • concentrations of protein S-100 B and glial fibrillary
  • acidic protein. Stroke 2000; 31: 2670-2677.
  • Missler U, Wiesmann M, Friedrich C, Kaps M. S-100
  • Protein and neuron-specific enolase concentrations in
  • blood as indicators of infarction volume and prognosis
  • in acute ischemic stroke. Stroke 1997; 28: 1956-1960.
  • Wunderlich MT, Ebert AD, Kratz T, Goertler M, Jost S,
  • Hermann M. Early neurobehavioral outcome after stroke
  • is related to release of neurobiochemical markers of
  • brain damage. Stroke 1999; 30: 1190-1195.
  • Foerch C, Otto B, Singer O C, Haefelin T N, Yan B,
  • Berkefeld J, Steinmetz H et al. Serum S-100 B predicts a
  • malignant course of infarction in patients with acute
  • middle cerebral artery occlusion. Stroke 2004; 35: 2160-
  • -
  • Foerch C, Singer O C, Haefilin TN, Rochemont M,
  • Steinmetz H. Evaluation of Serum S-100 B as a
  • surragate marker for long-term outcome and infarct
  • volume in acute middle cerebral artery infarction. Arch
  • Neurol 2005 ;62: 1130-1134.
There are 70 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Gülay Kenangil This is me

A. Yalçın This is me

Gonca Haklar This is me

Hasan Cacina This is me

Hulki Forta This is me

Publication Date June 29, 2015
Published in Issue Year 2004 Volume: 17 Issue: 3

Cite

APA Kenangil, G., Yalçın, A., Haklar, G., Cacina, H., et al. (2015). SERUM S-100 PROTEİNİNİN ENFARKT BOYUTU VE KLİNİK PROGNOZ İLE İLİŞKİSİ. Marmara Medical Journal, 17(3), 105-108.
AMA Kenangil G, Yalçın A, Haklar G, Cacina H, Forta H. SERUM S-100 PROTEİNİNİN ENFARKT BOYUTU VE KLİNİK PROGNOZ İLE İLİŞKİSİ. Marmara Med J. August 2015;17(3):105-108.
Chicago Kenangil, Gülay, A. Yalçın, Gonca Haklar, Hasan Cacina, and Hulki Forta. “SERUM S-100 PROTEİNİNİN ENFARKT BOYUTU VE KLİNİK PROGNOZ İLE İLİŞKİSİ”. Marmara Medical Journal 17, no. 3 (August 2015): 105-8.
EndNote Kenangil G, Yalçın A, Haklar G, Cacina H, Forta H (August 1, 2015) SERUM S-100 PROTEİNİNİN ENFARKT BOYUTU VE KLİNİK PROGNOZ İLE İLİŞKİSİ. Marmara Medical Journal 17 3 105–108.
IEEE G. Kenangil, A. Yalçın, G. Haklar, H. Cacina, and H. Forta, “SERUM S-100 PROTEİNİNİN ENFARKT BOYUTU VE KLİNİK PROGNOZ İLE İLİŞKİSİ”, Marmara Med J, vol. 17, no. 3, pp. 105–108, 2015.
ISNAD Kenangil, Gülay et al. “SERUM S-100 PROTEİNİNİN ENFARKT BOYUTU VE KLİNİK PROGNOZ İLE İLİŞKİSİ”. Marmara Medical Journal 17/3 (August 2015), 105-108.
JAMA Kenangil G, Yalçın A, Haklar G, Cacina H, Forta H. SERUM S-100 PROTEİNİNİN ENFARKT BOYUTU VE KLİNİK PROGNOZ İLE İLİŞKİSİ. Marmara Med J. 2015;17:105–108.
MLA Kenangil, Gülay et al. “SERUM S-100 PROTEİNİNİN ENFARKT BOYUTU VE KLİNİK PROGNOZ İLE İLİŞKİSİ”. Marmara Medical Journal, vol. 17, no. 3, 2015, pp. 105-8.
Vancouver Kenangil G, Yalçın A, Haklar G, Cacina H, Forta H. SERUM S-100 PROTEİNİNİN ENFARKT BOYUTU VE KLİNİK PROGNOZ İLE İLİŞKİSİ. Marmara Med J. 2015;17(3):105-8.