ENDOTEL PROGENİTÖR HÜCRELER

Year 2007, Volume: 20 Issue: 1, 59 - 65, 25.06.2015

S. Özgür Tekeli Kaya Emerk

Abstract

Endotelyal progenitör hücreler (EPH) gelecek yıllarda vasküler hastalıkların tedavi yöntemleri arasına
girmeye adaydır. Postnatal süreçte de fonksiyonlarını devam ettirdikleri kanıtlanan EPH’ler kemik iliğinde
olgunlaşıp, dolaşıma çıkarak vasküler hasarın olduğu bölgelerde yoğunlaşıp hasarın tamir edilmesinde
merkezi rol alırlar. EPH’ler kemik iliğinden ayrıldıktan sonra hücre yüzey belirteçlerinde birtakım
değişiklikler geçirerek olgun endotel hücrelere dönüşebilirler. Günümüzde EPH’lerle ilişkili hem klinik hem
de deneysel çalışmalar oldukça artmıştır. Fakat EPH’lerin olgunlaşmasını, göçünü ve hasarlı bölgeye
yerleşmesini sağlayan mekanizmalar tam olarak aydınlatılmış değildir.

Keywords

Endotelyal progenitör hücreler, vaskülogenez, anjiogenez, tamir, endotelyal hücreler

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