AKUT MYOKARD ENFARKTÜSÜNDE YÜKSELMİŞ SERUM CRP DÜZEYİ VE DİABETES MELLİTUS İLE İLİŞKİSİ

Yıl 2006, Cilt: 19 Sayı: 2, 58 - 64, 26.06.2015

Kenan Topal Sunay Sandıkçı Hakan Demirhindi Ersin Akpınar Esra Saatçı

Öz

Amaç: Günümüzde aterosklerozun enflamatuar bir hastalık olduğu ve serum CRP düzeyinin, aterosklerozun şiddeti ve genişliği ile korele şekilde yükseldiği kabul edilmektedir. Bu çalışmada, Ocak 2000 ile Temmuz 2000 tarihleri arasında, Adana Numune Eğitim ve Araştırma Hastanesi Koroner Yoğun Bakım Ünitesi’ne (KYBÜ) AMİ tanısıyla yatırılıp trombolitik tedavi uygulanan 55 hastada infarkt tipi ve genişliği ile serum CRP düzeyleri arasındaki ilişki incelendi.

Gereç ve Yöntem: Göğüs ağrısının başlangıcından itibaren 12. saatte serum CRP, kardiak troponin İ, CK-MB, LDH, AST, beyaz küre, sedimantasyon düzeyleri incelendi.

Bulgular: Serum CRP düzeyi ortalama 24.5 mg/L, beyaz küre sayısı ortalama 14.2 X10³/ml olup belirgin olarak yüksekti. Serum CRP düzeyi ile infarkt tipi ve genişliği arasında ilişki yoktu. Ayrıca CRP yüksekliği ile diabetes mellitus varlığı arasında pozitif yönde bir ilişki olduğu görüldü (r: 0.479, p<0.01).

Sonuç: AMİ’nde serum CRP düzeyinin yükselmesi, akut koroner sendromlarda enflamasyonun rolünü göstermesi açısından önemlidir.

Anahtar Kelimeler: Ateroskleroz, enflamasyon, CRP, akut myokard enfarktüsü

Anahtar Kelimeler

Ateroskleroz, enflamasyon, CRP, akut myokard enfarktüsü

Kaynakça

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