The neuroprotective and anti-inflammatory effects of Annona muricata (Graviola) on radiation-induced rat sciatic nerve injury

Yıl 2022, Cilt: 35 Sayı: 2, 211 - 218, 30.05.2022

Emrah Keskın Ozlem Elmas Havva Hande Keser Sahın Caghan Tonge Ahmet Gunaydın

https://doi.org/10.5472/marumj.1121375

Cited By: 1

Öz

Objective: This study aimed to evaluate Annona muricata’s (AM) radioprotective effects on sciatic nerve injury due to ionising
radiation (IR).

Materials and Methods: Thirty-two adult female Wistar albino rats were separated into four equal groups; Control (C), Annona
muricata leaf extracts (AME), radiation (RAD), radiation and AME (AME+RAD). In groups AME and AME+RAD, AME was
administered at a dose of 300 mg/kg for the first day and 50 mg/every day for the following one week intraperitoneally. In RAD and
AME+RAD, rats were exposed to a single dose of 20 Gray (Gy) IR to their right legs. All the subjects were sacrificed at the end of
the first month. Oxidative stress biochemical parameters from blood samples were analysed. In addition, right sciatic nerves were
extracted and histomorphology was evaluated.

Results: Statistically significant vasculature, degenerative and necrotic changes were observed in RAD, compared to C and AME
(p<0.01). Swelling in myelin sheath was predominantly seen in RAD. Alterations in the level of catalase (p<0.01), superoxide
dismutase (p<0.01) and glutathione peroxidase (p<0.05) in the AME+RAD group compared to the RAD group were found to be
statistically significant.

Conclusion: Our study unveiled that AM could potentially enhance biochemical and histomorphological healing in the acute period
on sciatic nerve injury due to IR.

Anahtar Kelimeler

Radiation, Sciatic nerve, Annona muricata, Neuroprotection, Oxidative stress

Kaynakça

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