Araştırma Makalesi
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Yıl 2022, Cilt: 35 Sayı: 3, 281 - 287, 31.10.2022
https://doi.org/10.5472/marumj.1186858

Öz

Kaynakça

  • Belwal T, Devkota HP, Singh MK, et al. St. John’s Wort (Hypericum Perforatum) in Nonvitamin and Nonmineral Nutrirional Supplements. Nabavi SM, Silva AS. Elsevier Inc.; 2019. Chapter 3.40. https://doi.org/10.1016/C2016-0-03546-5
  • Klemow KM, Bartlow A, Crawford J, Kocher N, Shah J, Ritsick M. Medical Attributes of St. John’s Wort (Hypericum perforatum). In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd ed. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 11. PMID: 22593920
  • Barrientos S, Brem H, Stojadinovic O, et al. Clinical application of growth factors and cytokines in wound healing. Wound Repair Regen 2014;22:5:569-78. doi:10.1111/wrr.12205
  • Topal Hançer A, Yılmaz Pınar. Editöre mektup: Balın Yara İyileşmesi Üzerine Etkisinin Değerlendirilmesi. Bozok Tıp Derg 2019;9:1:152-9. doi:10.16919/bozoktip.399768
  • Rodrigues M, Kosaric N, Bonham CA, et al. Wound healing: A cellular perspective. Physiol Rev 2019;99:1:665-706. doi:10.1152/physrev.00067.2017
  • Gunpinar S, Kilic OA, Duran I, et al. Tosun M, Firat T, Soyler G. Evaluation of the Effect of Topical Hypericum perforatum Oil on Excisional Palatal Wound Healing in Rabbits. J Investig Surg 2020;33:1:49-58. doi:10.1080/08941.939.2018.1474980
  • Abd Jalil MA, Kasmuri AR, Hadi H. Stingless bee honey, the natural wound healer: A review. Skin Pharmacol Physiol 2017;30:2:66-75. doi:10.1159/000458416
  • Trautinger F, Schwarz T, Luger T. Cytokines in dermatotherapy. J Dermatolog Treat 1992;3:3:143-152. doi:10.3109/095.466.39209088710
  • Morelli T, Neiva R, Nevins ML, et al. Angiogenic biomarkers and healing of living cellular constructs J Dent Res. 2011;90:4:456-62. doi:10.1177/002.203.4510389334
  • Murthy S, Gautam MK, Goel S, et al. Evaluation of in vivo wound healing activity of Bacopa monniera on different wound model in rats. Biomed Res Int 2013;2013. doi:10.1155/2013/972028
  • Yücel A, Kan Y, Yesilada E, Akın O. Effect of St.John’s wort (Hypericum perforatum) oily extract for the care and treatment of pressure sores; a case report. J Ethnopharmacol 2017;196:236-41. doi:10.1016/j.jep.2016.12.030
  • Grundmann O, Lv Y, Kelber O, et al. Mechanism of St. John’s wort extract (STW3-VI) during chronic restraint stress is mediated by the interrelationship of the immune, oxidative defense, and neuroendocrine system. Neuropharmacology 2010;58:4-5:767-73. doi:10.1016/j.neuropharm.2009.12.014
  • Fiebich BL, Höllig A, Lieb K. Inhibition of substance P-induced cytokine synthesis by St. John’s wort extracts. Pharmacopsychiatry 2001;34: 1:26-8. doi:10.1055/s-2001-15462
  • DeRose V, Robbins R, Snider R, et al. Substance P increases neutrophil adhesion to bronchial epithelial cells. J Immunol 1994;152:3:1339–46
  • Lu YH, Du C Bin, Liu JW, et al. Neuroprotective effects of Hypericum perforatum on trauma induced by hydrogen peroxide in PC12 cells. Am J Chin Med 2004;32:3:397-405. doi:10.1142/S0192415X04002053
  • Silva B, Oliveira PJ, Dias A, et al. Quercetin, kaempferol and biapigenin from hypericum perforatum are neuroprotective against excitotoxic insults. Neurotox Res 2008;13:3-4:265-79. doi:10.1007/BF03033510
  • Zou Y, Lu Y, Wei D. Antioxidant activity of a flavonoid-rich extract of Hypericum perforatum L. in vitro. J Agric Food Chem 2004;52:16:5032-39. doi:10.1021/jf049571r
  • Sánchez-Reus MI, Gómez del Rio MA, Iglesias I, et al. Standardized Hypericum perforatum reduces oxidative stress and increases gene expression of antioxidant enzymes on rotenone-exposed rats. Neuropharmacology 2007;52:2:606- 16.doi:10.1016/j.neuropharm.2006.09.003
  • Han MC, Durmuş AS, Sağliyan A, et al. Effects of Nigella sativa and Hypericum perforatum on wound healing. Turkish J Vet Anim Sci 2017;41:1:99-105. doi:10.3906/vet-1603-26
  • Bilgen F, Ural A, Kurutas EB, Bekerecioglu M. The effect of oxidative stress and Raftlin levels on wound healing. Int Wound J 2019;16:5:1178-84. doi:10.1111/iwj.13177

Partial healing effects of St. John’s wort oil on the rat excisional wound model

Yıl 2022, Cilt: 35 Sayı: 3, 281 - 287, 31.10.2022
https://doi.org/10.5472/marumj.1186858

Öz

Objective: St. John’s wort (SJW) oil (Hypericum perforatum) has been used for its immunomodulatory and anti-inflammatory effects.
Several studies have shown the efficacy of SJW on wound healing. The aim of this study is to assess the effectiveness of SJW using a
combination of biochemical, histopathological and laser Doppler evaluations.
Materials and Methods: Sixteen young Wistar albino rats were used as case and control groups (having 8 in each group). After
anesthesia protocol, 6 mm punch biopsy was taken from six separate sites on the rats’ dorsal skin. Three wounds were stitched (closed
wounds); three wounds were left as they were (open wounds). SJW oil was administered topically to case group once a day for 14 days.
Controls did not receive any treatment.
Results: There was no statistical difference in blood perfusion between the groups. No statistical difference was present between the
groups in GPx (glutathione peroxidase)values. Rat MDA (malonyldialdehyde) values were higher in the case group compared to the
control group. SJW oil was found to be beneficial and effective within some histological parameters.
Conclusion: SJW may be an effective salve within some parameters. Nevertheless, this judgment is uncertain due to the low sample
size. We encourage further studies on this promising natural medicine.

Kaynakça

  • Belwal T, Devkota HP, Singh MK, et al. St. John’s Wort (Hypericum Perforatum) in Nonvitamin and Nonmineral Nutrirional Supplements. Nabavi SM, Silva AS. Elsevier Inc.; 2019. Chapter 3.40. https://doi.org/10.1016/C2016-0-03546-5
  • Klemow KM, Bartlow A, Crawford J, Kocher N, Shah J, Ritsick M. Medical Attributes of St. John’s Wort (Hypericum perforatum). In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd ed. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 11. PMID: 22593920
  • Barrientos S, Brem H, Stojadinovic O, et al. Clinical application of growth factors and cytokines in wound healing. Wound Repair Regen 2014;22:5:569-78. doi:10.1111/wrr.12205
  • Topal Hançer A, Yılmaz Pınar. Editöre mektup: Balın Yara İyileşmesi Üzerine Etkisinin Değerlendirilmesi. Bozok Tıp Derg 2019;9:1:152-9. doi:10.16919/bozoktip.399768
  • Rodrigues M, Kosaric N, Bonham CA, et al. Wound healing: A cellular perspective. Physiol Rev 2019;99:1:665-706. doi:10.1152/physrev.00067.2017
  • Gunpinar S, Kilic OA, Duran I, et al. Tosun M, Firat T, Soyler G. Evaluation of the Effect of Topical Hypericum perforatum Oil on Excisional Palatal Wound Healing in Rabbits. J Investig Surg 2020;33:1:49-58. doi:10.1080/08941.939.2018.1474980
  • Abd Jalil MA, Kasmuri AR, Hadi H. Stingless bee honey, the natural wound healer: A review. Skin Pharmacol Physiol 2017;30:2:66-75. doi:10.1159/000458416
  • Trautinger F, Schwarz T, Luger T. Cytokines in dermatotherapy. J Dermatolog Treat 1992;3:3:143-152. doi:10.3109/095.466.39209088710
  • Morelli T, Neiva R, Nevins ML, et al. Angiogenic biomarkers and healing of living cellular constructs J Dent Res. 2011;90:4:456-62. doi:10.1177/002.203.4510389334
  • Murthy S, Gautam MK, Goel S, et al. Evaluation of in vivo wound healing activity of Bacopa monniera on different wound model in rats. Biomed Res Int 2013;2013. doi:10.1155/2013/972028
  • Yücel A, Kan Y, Yesilada E, Akın O. Effect of St.John’s wort (Hypericum perforatum) oily extract for the care and treatment of pressure sores; a case report. J Ethnopharmacol 2017;196:236-41. doi:10.1016/j.jep.2016.12.030
  • Grundmann O, Lv Y, Kelber O, et al. Mechanism of St. John’s wort extract (STW3-VI) during chronic restraint stress is mediated by the interrelationship of the immune, oxidative defense, and neuroendocrine system. Neuropharmacology 2010;58:4-5:767-73. doi:10.1016/j.neuropharm.2009.12.014
  • Fiebich BL, Höllig A, Lieb K. Inhibition of substance P-induced cytokine synthesis by St. John’s wort extracts. Pharmacopsychiatry 2001;34: 1:26-8. doi:10.1055/s-2001-15462
  • DeRose V, Robbins R, Snider R, et al. Substance P increases neutrophil adhesion to bronchial epithelial cells. J Immunol 1994;152:3:1339–46
  • Lu YH, Du C Bin, Liu JW, et al. Neuroprotective effects of Hypericum perforatum on trauma induced by hydrogen peroxide in PC12 cells. Am J Chin Med 2004;32:3:397-405. doi:10.1142/S0192415X04002053
  • Silva B, Oliveira PJ, Dias A, et al. Quercetin, kaempferol and biapigenin from hypericum perforatum are neuroprotective against excitotoxic insults. Neurotox Res 2008;13:3-4:265-79. doi:10.1007/BF03033510
  • Zou Y, Lu Y, Wei D. Antioxidant activity of a flavonoid-rich extract of Hypericum perforatum L. in vitro. J Agric Food Chem 2004;52:16:5032-39. doi:10.1021/jf049571r
  • Sánchez-Reus MI, Gómez del Rio MA, Iglesias I, et al. Standardized Hypericum perforatum reduces oxidative stress and increases gene expression of antioxidant enzymes on rotenone-exposed rats. Neuropharmacology 2007;52:2:606- 16.doi:10.1016/j.neuropharm.2006.09.003
  • Han MC, Durmuş AS, Sağliyan A, et al. Effects of Nigella sativa and Hypericum perforatum on wound healing. Turkish J Vet Anim Sci 2017;41:1:99-105. doi:10.3906/vet-1603-26
  • Bilgen F, Ural A, Kurutas EB, Bekerecioglu M. The effect of oxidative stress and Raftlin levels on wound healing. Int Wound J 2019;16:5:1178-84. doi:10.1111/iwj.13177
Toplam 20 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Makaleler
Yazarlar

Ayse Nilhan Aksu Bu kişi benim 0000-0001-6571-9612

Tayfun Bılgıc Bu kişi benim 0000-0002-7564-3663

Cavit Kerem Kayhan Bu kişi benim 0000-0001-5754-9289

Zumrut Mine Isık Saglam Bu kişi benim 0000-0001-8142-3213

Nazli Caf Bu kişi benim 0000-0001-9364-9236

Yayımlanma Tarihi 31 Ekim 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 35 Sayı: 3

Kaynak Göster

APA Aksu, A. N., Bılgıc, T., Kayhan, C. K., Isık Saglam, Z. M., vd. (2022). Partial healing effects of St. John’s wort oil on the rat excisional wound model. Marmara Medical Journal, 35(3), 281-287. https://doi.org/10.5472/marumj.1186858
AMA Aksu AN, Bılgıc T, Kayhan CK, Isık Saglam ZM, Caf N. Partial healing effects of St. John’s wort oil on the rat excisional wound model. Marmara Med J. Ekim 2022;35(3):281-287. doi:10.5472/marumj.1186858
Chicago Aksu, Ayse Nilhan, Tayfun Bılgıc, Cavit Kerem Kayhan, Zumrut Mine Isık Saglam, ve Nazli Caf. “Partial Healing Effects of St. John’s Wort Oil on the Rat Excisional Wound Model”. Marmara Medical Journal 35, sy. 3 (Ekim 2022): 281-87. https://doi.org/10.5472/marumj.1186858.
EndNote Aksu AN, Bılgıc T, Kayhan CK, Isık Saglam ZM, Caf N (01 Ekim 2022) Partial healing effects of St. John’s wort oil on the rat excisional wound model. Marmara Medical Journal 35 3 281–287.
IEEE A. N. Aksu, T. Bılgıc, C. K. Kayhan, Z. M. Isık Saglam, ve N. Caf, “Partial healing effects of St. John’s wort oil on the rat excisional wound model”, Marmara Med J, c. 35, sy. 3, ss. 281–287, 2022, doi: 10.5472/marumj.1186858.
ISNAD Aksu, Ayse Nilhan vd. “Partial Healing Effects of St. John’s Wort Oil on the Rat Excisional Wound Model”. Marmara Medical Journal 35/3 (Ekim 2022), 281-287. https://doi.org/10.5472/marumj.1186858.
JAMA Aksu AN, Bılgıc T, Kayhan CK, Isık Saglam ZM, Caf N. Partial healing effects of St. John’s wort oil on the rat excisional wound model. Marmara Med J. 2022;35:281–287.
MLA Aksu, Ayse Nilhan vd. “Partial Healing Effects of St. John’s Wort Oil on the Rat Excisional Wound Model”. Marmara Medical Journal, c. 35, sy. 3, 2022, ss. 281-7, doi:10.5472/marumj.1186858.
Vancouver Aksu AN, Bılgıc T, Kayhan CK, Isık Saglam ZM, Caf N. Partial healing effects of St. John’s wort oil on the rat excisional wound model. Marmara Med J. 2022;35(3):281-7.