Carotid intima-media thickness correlated with age and pulse wave velocity in ANCA-associated vasculitis patients

Yıl 2024, Cilt: 37 Sayı: 3, 290 - 294, 30.10.2024

Tuba Nur Izgi Dilek Barutcu Atas , Halil Atas , Can Ilgın , Arzu Velioglu , İzzet Hakkı Arıkan , Fatma Alibaz Öner , Haner Direskeneli , Serhan Tuğlular , Ebru Aşıcıoğlu

https://doi.org/10.5472/marumj.1571918

Öz

Objective: Cardiovascular diseases are the main causes of mortality in the anti-neutrophil cytoplasmic antibody (ANCA)-associated
vasculitis (AAV) patients. Carotid intima-media thickness (CIMT) measurement and pulse wave velocity (PWV) were performed to
determine atherosclerosis and arterial stiffness as cardiovascular risk markers.
Patients and Methods: The data of 31 patients with AAV were compared with 21 healthy controls. Demographic and laboratory
findings were recorded.
Results: Seventeen patients (54.8%) were male. Mean age was 52.6±11.5 years. CIMT was higher in the patient group [0.74 (0.65 – 0.84)
vs 0.63 (0.57-0.74) mm; p=0.048]. PWV [7.9 (6.7-9.3) vs 7.8 (6.8-8.5) m/s; p=0.295] and augmentation index (AI) [22.5 (11.0-30.0) vs.
23 (9.5-30.5) mm/Hg, p=0.801] were similar in both groups. CIMT was correlated with age (r: 0.538, p<0.001) and PWV (r: 0.554 p<
0.001) while there was no correlation with AI (r: 0.047, p= 0.764).
Conclusion: The present study showed that CIMT is significantly increased and correlated with age and PWV in patients with AAV
compared to controls. CIMT can be used as a screening tool as part of patient follow-up to identify patients at cardiac risk.

Anahtar Kelimeler

ANCA-associated vasculitis, Cardiovascular risk, Carotid intima media thickness, Pulse wave velocity

Kaynakça

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