Streptozotosin ile Tip-1 diyabet oluşturulan sıçanlarda acı badem yağının serum ve eritrositlerdeki bazı biyokimyasal parametrelere etkisi

Ersin Demir; Ökkeş Yılmaz

doi:10.12991/201414121

Streptozotosin ile Tip-1 diyabet oluşturulan sıçanlarda acı badem yağının serum ve eritrositlerdeki bazı biyokimyasal parametrelere etkisi

Abstract

ÖZET: Bu çalışma, Tip–1 diyabet oluşturulan sıçanlarda acı badem yağının serum ve eritrositlerdeki
bazı biyokimyasal parametreler üzerine etkisinin araştırılması için tasarlandı. Sıçanlar
kontrol (K), diyabet (STZ) ve diyabet+acı badem yağı (STZ+ABY) olmak üzere üç
grubu ayrıldı. Diyabet gruplarına intraperitoneal enjeksiyonla streptozotosin (65 mg/kg) verilerek
diyabet oluşturuldu. Acı badem yağı grubundaki sıçanlara haftada iki gün 1ml/kg dozunda
intraperitoneal enjeksiyonla acı badem yağı, ayrıca deney boyunca toz haline getirilmiş
2 gr acı badem çekirdeği, 500 ml içme suyuna eklenerek verildi. Kontrol grubuna göre,
STZ grubunda postprandial kan glukoz düzeyinin anlamlı olarak arttığı (p<0.001), STZ grubu
ile karşılaştırıldığında ise, STZ+ABY grubunda postprandial kan glukoz düzeyinin anlamlı
olarak azaldığı (p<0.001) belirlendi. Kontrol grubuna göre, STZ grubunun serum ve eritrositlerinde
malondialdehit (MDA) düzeyinin anlamlı olarak arttığı (p<0.001), eritrositlerde ise
glutatyon (GSH) düzeyinin anlamlı olarak azaldığı (p<0.001) belirlendi. STZ grubuna göre,
STZ+ABY grubunun serum ve eritrositlerinde MDA düzeyinin anlamlı olarak azaldığı
(p<0.001), eritrositlerde ise GSH düzeyinin anlamlı olarak arttığı (p<0.001) saptandı. STZ
grubuna göre, STZ+ABY grubunun serumunda palmitik ve linoleik asit değerlerinin, eritrositlerinde
ise; palmitik, palmitoleik, stearik, araşidonik ve dokosaheksaenoik asit değerlerinin
kontrol grubu değerlerine yaklaştığı belirlendi. STZ+ABY grubunda ayrıca serum
-tokoferol asetat ve -sitosterol düzeylerinin ve eritrositlerde ise -tokoferol düzeyinin
kontrol gurubu değerlerine yaklaştığı tespit edildi. Serumda STZ grubuna göre, STZ+ABY
grubunda -tokoferol düzeyinin arttığı belirlendi. Sonuç olarak, diyabetik sıçanlara uyguladığımız
acı badem yağının serum ve eritrositlerde, lipid peroksidasyon, glutatyon, yağ asidi ve
-tokoferol düzeyleri üzerinde olumlu etkileri bulunmaktadır. Elde ettiğimiz verilere göre, acı
bademin diyabet tedavisinde kullanılmasının iyi bir diyet stratejisi olabileceğini fakat bu çalışma
verilerinin kapsamlı çalışma verileri ile desteklenmesi gerektiğini düşünmekteyiz.
ANAHTAR KELİMELER: Diyabet, streptozotosin, acı badem yağı, lipid peroksidasyon,
 tokoferol, yağ asidi kompozisyonu

Keywords

Diyabet, streptozotosin, acı badem yağı, lipid peroksidasyon,  tokoferol, yağ asidi kompozisyonu

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Details

Primary Language

English

Subjects

-

Journal Section

-

Authors

Ersin Demir

Ökkeş Yılmaz This is me

Publication Date

January 16, 2014

Submission Date

January 16, 2014

Acceptance Date

-

Published in Issue

Year 2014 Volume: 18 Number: 1

DOI

https://doi.org/10.12991/201414121

IZ

https://izlik.org/JA97TU35LE

Cite

RIS / Bibtex

APA

Demir, E., & Yılmaz, Ö. (2014). Streptozotosin ile Tip-1 diyabet oluşturulan sıçanlarda acı badem yağının serum ve eritrositlerdeki bazı biyokimyasal parametrelere etkisi. Marmara Pharmaceutical Journal, 18(1), 13-21. https://doi.org/10.12991/201414121

AMA

1.Demir E, Yılmaz Ö. Streptozotosin ile Tip-1 diyabet oluşturulan sıçanlarda acı badem yağının serum ve eritrositlerdeki bazı biyokimyasal parametrelere etkisi. J Res Pharm. 2014;18(1):13-21. doi:10.12991/201414121

Chicago

Demir, Ersin, and Ökkeş Yılmaz. 2014. “Streptozotosin Ile Tip-1 Diyabet Oluşturulan Sıçanlarda Acı Badem Yağının Serum Ve Eritrositlerdeki Bazı Biyokimyasal Parametrelere Etkisi”. Marmara Pharmaceutical Journal 18 (1): 13-21. https://doi.org/10.12991/201414121.

EndNote

Demir E, Yılmaz Ö (April 1, 2014) Streptozotosin ile Tip-1 diyabet oluşturulan sıçanlarda acı badem yağının serum ve eritrositlerdeki bazı biyokimyasal parametrelere etkisi. Marmara Pharmaceutical Journal 18 1 13–21.

IEEE

[1]E. Demir and Ö. Yılmaz, “Streptozotosin ile Tip-1 diyabet oluşturulan sıçanlarda acı badem yağının serum ve eritrositlerdeki bazı biyokimyasal parametrelere etkisi”, J Res Pharm, vol. 18, no. 1, pp. 13–21, Apr. 2014, doi: 10.12991/201414121.

ISNAD

Demir, Ersin - Yılmaz, Ökkeş. “Streptozotosin Ile Tip-1 Diyabet Oluşturulan Sıçanlarda Acı Badem Yağının Serum Ve Eritrositlerdeki Bazı Biyokimyasal Parametrelere Etkisi”. Marmara Pharmaceutical Journal 18/1 (April 1, 2014): 13-21. https://doi.org/10.12991/201414121.

JAMA

1.Demir E, Yılmaz Ö. Streptozotosin ile Tip-1 diyabet oluşturulan sıçanlarda acı badem yağının serum ve eritrositlerdeki bazı biyokimyasal parametrelere etkisi. J Res Pharm. 2014;18:13–21.

MLA

Demir, Ersin, and Ökkeş Yılmaz. “Streptozotosin Ile Tip-1 Diyabet Oluşturulan Sıçanlarda Acı Badem Yağının Serum Ve Eritrositlerdeki Bazı Biyokimyasal Parametrelere Etkisi”. Marmara Pharmaceutical Journal, vol. 18, no. 1, Apr. 2014, pp. 13-21, doi:10.12991/201414121.

Vancouver

1.Ersin Demir, Ökkeş Yılmaz. Streptozotosin ile Tip-1 diyabet oluşturulan sıçanlarda acı badem yağının serum ve eritrositlerdeki bazı biyokimyasal parametrelere etkisi. J Res Pharm. 2014 Apr. 1;18(1):13-21. doi:10.12991/201414121