Evaluation of Anti-Diarrhoeal Activity of the Leaves Extract of Ficus Microcarpa L. (Moraceae)

Abstract

The aim of present study was to investigate the anti-diarrheal

activity of Ficus microcarpa against experimentally induced

diarrhea in rats. Albino rats were used for the experiment.

Anti-diarrheal activity was determined by castor oil induced

diarrhea. The extract of the bark administered orally at a

dose 300 mg/kg and 600 mg/kg. The extract of Ficus

microcarpa produced a marked anti-diarrheal effect in rats.

Both doses of extract significantly decreased (P<0.05) the

total number of wet feces produced by administration of

castor oil (4.31 at the dose of 300 mg/kg and 7.16 at the dose

of 600 mg/kg) as compared to the castor oil treated control

group (20.75). The Ficus microcarpa extract was found to

possess an anti-enteropooling activity. Oral administration of

castor oil produced a significant increase (P<0.05) in the

intestinal fluid (3.14 ml) as compared to the normal rat (1.29

ml). The extract when given orally one hour before castor

oil, significantly inhibited (P<0.05) the enteropooling; 1.48

ml (300mg/kg) and 1.68 ml (600mg/kg). The results revealed

that the extract inhibited the small intestinal motility of the

charcoal marker in the rats by 23.92-31.12% whereas the

inhibition was noted to be 61.2% in the case of treatment by

loperamide. The results of this investigation conclude that

the extract contains pharmacologically active substances

with anti-diarrheal properties. Further research is to be

carried out to fractionate and purify the extract, in order to

find the molecules responsible for the anti-diarrheal activity.

Keywords: Anti-diarrheal activity, Ficus Microcarpa, Castor

oil, Methanolic extract.

Keywords

• Anti-diarrheal activity, Ficus Microcarpa, Castor oil, Methanolic extract.

ORIGINAL RESEARCH

Abstract

Bu çalışmanın amacı, sıçanlarda deneysel olarak oluşturulan diyareye karşı Ficus microcarpa ekstresinin antidiyareik etkinliğini araştırmaktır. Deneylerde Albino sıçanlar kullanıldı. Antidiyareik aktivite hint yağı ile oluşturulan diyare modelinde çalışıldı. 300 mg/kg ve 600 mg/kg dozlarında Ficus microcarpa ekstresi sıçanlarda anlamlı bir anti diyareik etki gösterdi. Toplam ıslak dışkı sayısı hint yağı grubuna (20.75) göre ekstre tedavisi uygulanan gruplarda her iki dozda önemli ölçüde (P <0.05; 300 mg/kg ‘de 4.31 ve 600 mg/kg dozunda 7.16) azaldı. Ficus microcarpa ekstresinin anti- enteropooling etkinliğe sahip

Keywords

• Anti-diyareik aktivite, Ficus microcarpa, Hintyağı, Metanolik ekstre

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