Protective and Therapeutic Effects of Polygonum cognatum Meissn Aqueous Extract in Experimental Colitis

Abstract

The aim of the study was to investigate the protective and
therapeutic effects of Polygonum cognatum Meissn (PC) in
the treatment of colitis. Rats were orogastrically treated with
PC (2g/kg) throughout a 10-day interval before and/or after
colitis, which was induced by intracolonic administration of
acetic acid. Microscopic damage scores and scanning electron
microscopy changes of colon segments were analyzed. The
levels of interleukin-6 (IL-6) and tumor necrosis factor-alpha
(TNF-α) in serum, malonyldialdehyde (MDA), glutathione
(GSH), tissue factor (TF) levels, myeloperoxidase (MPO),
superoxide dismutase (SOD), catalase (CAT) and
gammaglutamyltransferase (GGT) activities in the colon
tissues were measured. PC treatment ameliorated the acetic
acid-induced disturbances in colonic tissue. Serum IL-6 and
TNF-α levels decreased with PC treated colitis group.
Colonic tissue GGT, MPO activities and MDA levels were
decreased on the other hand SOD, CAT activities and GSH
levels were increased in PC treated colitis group. PC was
effective in the treatment of acetic acid-induced colitis in
rats. This may be due to the supression and down regulation
of mediators in intestinal inflammatory response and the
expression of antioxidant and anti-inflammatory response.
In conclusion, PC can play an protective role by
downregulating the colonic tissue damage and oxidative
stress which may be related to modulating the activities of
antioxidant molecules in rat model of colitis.
Keywords: Polygonum cognatum Meissn, Oxidative Stress,
Colitis, Antioxidant, Anti-inflammatory

Keywords

• Polygonum cognatum Meissn, Oxidative Stress, Colitis, Antioxidant, Anti-inflammatory

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