Candida albicans effects the tissue factor activity of blood cells in Type II Diabetes Mellitus

Abstract

Disorders of hemostatic mechanism play a role in the
development of diabetic complications and cardiovascular
events. C. albicans infection is frequently found in diabetic
individuals compared to nondiabetic individuals. In this
study, the in vitro effect of Candida albicans on the tissue
factor activity of the PMNS, MNS and platelet cells, that
were isolated from the blood samples of healthy and
diabetic individuals, was determined. The isolated blood
cells were counted after the viability test has been checked.
C.albicans suspension was added to one part of the cells.
An equal volume phosphate buffer was added to other part
of the cells instead of C.albicans suspension. Tissue factor
activity of all blood cells was determined by the method of
Quick. Tissue factor activity of these cells was found to be
significantly changed in the presence of C.albicans. The
presence of diabetes was also significantly changed tissue
factor activity of the PMNs, MNs and platelet cells when
compared to the healthy individuals. The findings of this
study will contribute to the treatment of diabetic patients
with or without candida infection in terms of tissue factor
activity.
Keywords: Tissue factor activity, diabetes, Candida
albicans, leukocyte, platelet

Keywords

• Tissue factor activity, diabetes, Candida albicans, leukocyte, platelet

Candida albicans effects the tissue factor activity of blood cells in Type II Diabetes Mellitus

Abstract

References

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