Mechanical evaluation of matrix type transdermal therapeutic systems containing captopril

Year 2015, Volume: 19 Issue: 1 , 67 - 72 , 07.01.2015

Oya Kerimoğlu Sevinç Şahbaz , Ahmet Şehirli Betül Dortunç Göksel Şener

https://izlik.org/JA88FE67BM

Abstract

The objective of this study was to evaluate the
mechanical properties of transdermal therapeutic
systems (TTS) containing captopril together with
synthetic and pH independent polymers, Eudragit
RL 100 and RS 100. The formulations were
characterized in terms of their adhesiveness and
bioadhesiveness by using texture analyser. These
optimum formulations were chosen according to the
results of our previous study regarding in vitro
dissolution and ex vivo diffusion rate studies through
excised human skin by using Franz Diffusion Cell.
Results indicated that the mechanical properties of
the formulations were suitable to be used as a
transdermal patch.
Keywords: captopril, transdermal therapeutic
system, patch adhesiveness, patch bioadhesiveness,
texture analyser

Keywords

captopril , transdermal therapeutic system , patch adhesiveness , patch bioadhesiveness , texture analyser

Mechanical evaluation of matrix type transdermal therapeutic systems containing captopril

https://izlik.org/JA88FE67BM

Abstract

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