Taste Masked Oral Fast Dissolving Sublingual Strips of Rizatriptan Benzoate for Migraine Therapy

Abstract

The aim of present investigation was to develop a taste masked

fast dissolving sublingual strips of rizatriptan benzoate. The

fast dissolving strips (FDS) were prepared by solvent casting

method using polyox N-10 and polyethylene glycol 400 (PEG

400) as polymer and plasticizer respectively. The FDS were

evaluated for pH, folding endurance, tensile strength, moisture

absorption, disintegration time and in vitro dissolution. All

formulations were free from bubble and exhibited smooth

appearance. The pH of the films was acidic. It was observed

that increase in the concentration of polyox N-10 increased

the disintegration time but reduced the dissolution rate.

The formulation A2 showed all the evaluation parameters

within the acceptable range and was considered as optimized

formulation. The optimized formulation was subjected to the

taste masking and stability study. The results of taste masking

study indicated an efficient masking of the bitter taste of drug

by the flavouring agents in the film. The formulation A2 was

found to be stable for three months with an insignificant

change in the drug content and mean dissolution time (MDT).

The compatibility study performed using ATR-FTIR and

DSC analysis indicated absence of any unusual interaction

between drug and excipients used in formulation. Thus, the

FDS comprised of polyox N-10 and PEG 400 may be a better

alternative to the other available fast dissolving systems for

delivery of rizatriptan benzoate.

Keywords

• Fast dissolving strips,Polyox N-10,PEG 400,Rizatriptan benzoate

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