Kemoterapötiklerin erkek üreme sistemi üzerindeki yan etkileri ve koruyucu stratejiler

Yıl 2013, Cilt: 17 Sayı: 2, 73 - 92, 24.10.2014

Gaffari Türk

Öz

Sitotoksik kemoterapi pek çok kanser türünün tedavisinde etkili bir yöntem olmasına
rağmen organizmada sayısız yan etkilere neden olmaktadır. İnfertilite de kemoterapötik ilaçların
hem erkek hem de dişilerde meydana getirdiği en önemli yan etkilerden biridir. Cinsel
isteksizlik, oligo-, azoo-, astenozoo- ve teratozoo-spermi, testiküler yapı, spermatogenesis
ve steroidogenesisteki bozukluklar, gonadotropin düzeylerindeki değişiklikler, sperm DNA
ve kromozomlarındaki hasarlar ve hatta tam sterilite hem kanserli erkekler hem de sağlıklı
deney hayvanlarında bildirilen kemoterapi kaynaklı yan etkilerdir. Kemoterapötiklerin erkeklerdeki
gonadotoksik etkilerinin önlenmesine yönelik hormon ve antioksidan uygulamalar ile
sperma ve germ hücrelerinin dondurularak saklanması gibi birtakım yöntemler kullanılmaktadır.
Bu derlemede kanser tedavisinde yaygın olarak kullanılan kemoterapötiklerin kanserli
ve sağlıklı erkeklerin üreme organ, doku ve hücrelerinde meydana getirdiği yan etkiler ve bu
etkilerin azaltılması veya önlenmesine yönelik koruyucu stratejiler ile ilgili literatür bilgiler
sunulmaktadır.

Anahtar Kelimeler

Antioksidan; kemoterapötik; kriyoprezervasyon; oksidatif stres; sperm; testis

Kaynakça

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