Protective effect of erdosteine against naphthalene-induced oxidative stress in rats

Year 2010, Volume: 14 Issue: 2, 67 - 73, 03.03.2014

Ahmet Şehirli Göksel Şener

Abstract

ABSTRACT: In this study the role of free radicals in naphthalene-induced toxicity and the
protection by erdosteine are investigated. Female Sprague-Dawley rats were treated with a
single oral dose of 1100 mg naphthalene/kg in corn oil. Erdosteine was given 50 mg/kg/day
orally for 3 days before naphthalene treatment and rats were decapitated 24 hours after
naphthalene administration. Liver and kidney tissue samples were taken for determination
of malondialdehyde (MDA), glutathione (GSH), Na+, K+-ATPase and myeloperoxidase
(MPO) activities. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood
urea nitrogen (BUN) and creatinine levels and lactate dehydrogenase (LDH) activity were
measured in the serum samples, while TNF-

Keywords

Naphthalene, erdosteine, lipid peroxidation, glutathione, myeloperoxidase

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