A Preliminary Study on the Use of Ultrasound for Obtaining Pulsatile Release

Yıl 2014, Cilt: 18 Sayı: 3, 101 - 108, 12.09.2014

Yelda Komesli , Emel Çetin Levent Kırılmaz Evren Gündoğdu

Öz

In this study, the controlled release tablet of diltiazem

hydrochloride was developed. The controlled release

tablets were prepared with ethyl cellulose by changing

the ratio of diltiazem hydrochloride and the in vitro

release studies were carried out by using an ultrasonic

water bath. According to release results, a new equation

was developed that can be used to estimate the release of

drug as a function of time and drug content in the

formulation. In addition, the effect of ultrasound on the

release of diltiazem hydrochloride from controlled

release dosage forms and relationships between release

rate constants and drug contents were investigated. This

study showed that the developed equation can

successfully be used to estimate the effect of ultrasound

on the release of drug from the formulations prepared

with different concentrations of diltiazem hydrochloride.

It was concluded that ultrasound has a very important

effect on the release of drug and increases drug release

obviously.

Keywords: ultrasound; controlled release; pulsatile

release

Anahtar Kelimeler

ultrasound; controlled release; pulsatile release

ORIGINAL RESEARCH

Öz

Kaynakça

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