The aim of present study was to investigate the anti-diarrheal
activity of Ficus microcarpa against experimentally induced
diarrhea in rats. Albino rats were used for the experiment.
Anti-diarrheal activity was determined by castor oil induced
diarrhea. The extract of the bark administered orally at a
dose 300 mg/kg and 600 mg/kg. The extract of Ficus
microcarpa produced a marked anti-diarrheal effect in rats.
Both doses of extract significantly decreased (P<0.05) the
total number of wet feces produced by administration of
castor oil (4.31 at the dose of 300 mg/kg and 7.16 at the dose
of 600 mg/kg) as compared to the castor oil treated control
group (20.75). The Ficus microcarpa extract was found to
possess an anti-enteropooling activity. Oral administration of
castor oil produced a significant increase (P<0.05) in the
intestinal fluid (3.14 ml) as compared to the normal rat (1.29
ml). The extract when given orally one hour before castor
oil, significantly inhibited (P<0.05) the enteropooling; 1.48
ml (300mg/kg) and 1.68 ml (600mg/kg). The results revealed
that the extract inhibited the small intestinal motility of the
charcoal marker in the rats by 23.92-31.12% whereas the
inhibition was noted to be 61.2% in the case of treatment by
loperamide. The results of this investigation conclude that
the extract contains pharmacologically active substances
with anti-diarrheal properties. Further research is to be
carried out to fractionate and purify the extract, in order to
find the molecules responsible for the anti-diarrheal activity.
Keywords: Anti-diarrheal activity, Ficus Microcarpa, Castor
oil, Methanolic extract.
Bu çalışmanın amacı, sıçanlarda deneysel olarak oluşturulan diyareye karşı Ficus microcarpa ekstresinin antidiyareik etkinliğini araştırmaktır. Deneylerde Albino sıçanlar kullanıldı. Antidiyareik aktivite hint yağı ile oluşturulan diyare modelinde çalışıldı. 300 mg/kg ve 600 mg/kg dozlarında Ficus microcarpa ekstresi sıçanlarda anlamlı bir anti diyareik etki gösterdi. Toplam ıslak dışkı sayısı hint yağı grubuna (20.75) göre ekstre tedavisi uygulanan gruplarda her iki dozda önemli ölçüde (P <0.05; 300 mg/kg ‘de 4.31 ve 600 mg/kg dozunda 7.16) azaldı. Ficus microcarpa ekstresinin anti- enteropooling etkinliğe sahip
Primary Language | English |
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Journal Section | Articles |
Authors | |
Publication Date | September 12, 2014 |
Published in Issue | Year 2014 Volume: 18 Issue: 3 |
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