BibTex RIS Kaynak Göster

Evaluation of Anti-Diarrhoeal Activity of the Leaves Extract of Ficus Microcarpa L. (Moraceae)

Yıl 2014, Cilt: 18 Sayı: 3, 135 - 138, 12.09.2014

Öz

The aim of present study was to investigate the anti-diarrheal

activity of Ficus microcarpa against experimentally induced

diarrhea in rats. Albino rats were used for the experiment.

Anti-diarrheal activity was determined by castor oil induced

diarrhea. The extract of the bark administered orally at a

dose 300 mg/kg and 600 mg/kg. The extract of Ficus

microcarpa produced a marked anti-diarrheal effect in rats.

Both doses of extract significantly decreased (P<0.05) the

total number of wet feces produced by administration of

castor oil (4.31 at the dose of 300 mg/kg and 7.16 at the dose

of 600 mg/kg) as compared to the castor oil treated control

group (20.75). The Ficus microcarpa extract was found to

possess an anti-enteropooling activity. Oral administration of

castor oil produced a significant increase (P<0.05) in the

intestinal fluid (3.14 ml) as compared to the normal rat (1.29

ml). The extract when given orally one hour before castor

oil, significantly inhibited (P<0.05) the enteropooling; 1.48

ml (300mg/kg) and 1.68 ml (600mg/kg). The results revealed

that the extract inhibited the small intestinal motility of the

charcoal marker in the rats by 23.92-31.12% whereas the

inhibition was noted to be 61.2% in the case of treatment by

loperamide. The results of this investigation conclude that

the extract contains pharmacologically active substances

with anti-diarrheal properties. Further research is to be

carried out to fractionate and purify the extract, in order to

find the molecules responsible for the anti-diarrheal activity.

Keywords: Anti-diarrheal activity, Ficus Microcarpa, Castor

oil, Methanolic extract.

Kaynakça

  • Mani M, Sachan N, Tandon A, Wahi AK. Anti-diarrheal activity of methanolic extract of root bark of Ailanthus altissima Swingle (Family: Simaroubaceae) on experimental animals. Int J Pharm Sci Res 2010;1:197-202.
  • Park K. Park’s Textbook of preventive and social medicine. Jabalpur, India: M/S Banarsidas Bharat Publishes; 2000;172-5.
  • Mohammed A, Ahmed H, Goji ADT, Okpanachi AO, Ezekiel I, Tanko Y. Preliminary Anti-diarrheal Activity of Hydromethanolic Extract of Aerial Part of Indigofera pulchra in Rodents. Asian J Med Sci; 2009; 1: 22-5.
  • Wagner WL, Herbst DR, Sohmer SH. Manual of the Flowering Plants of Hawaii. 2 nd ed. Honolulu: University of Hawaii and Bishop Museum Press; 1999.
  • Warrier PK, Nambiar VPK, Ramankutty C. Indian Medicinal Plants a Compendium of 500 Species.3 rd ed. Madras: Orient Longman; 1995.
  • Chiang YM, Chang JY, Kuo CC. Cytotoxic triterpenes from the aerial roots of Ficus microcarpa. J Phytochemistry 2005; 66: 495-501.
  • Taira T, Ohdomari A, Nakama N,Shimoji M, Ishihara M. Characterization and antifungal activity of gazyumaru (Ficus microcarpa) latex chitinase: Both the chitin-binding and the antifungal activities of class 1 chitinase are reinforced with increasing ionic strength. Biosci Biotechnol Biochem 2005; 69: 811-8.
  • Nasrin A, Iran R, Amir M. Hepatoprotective Activity of Capparis spinosa Root Bark Against CCl4 Induced Hepatic Damage in Mice. Iranian Journal of Pharmaceutical Research 2007; 6: 285-90.
  • Trease G.E. and W.C. Evans. Textbook of Pharmacognosy. 15th Edn. London: Bailliere Tindal;2006,135-9.
  • Hilaly JE, Israili Z.H, Lyoussi B. Acute and chronic toxicological studies of Ajuga iva in experimental animals. J Ethnopharmacol 2004; 91: 43-50.
  • Doherty SS. Inhibition of arachinodic acid release, mechanism by which glucocorticoids inhibit endotoxin-induced diarrhea. British J Pharmacol 1981; 73: 549-54.
  • Zaval MA, Pera ZS, Perez P, Vargan R, Perz RM. Antidiarrheal activity of Waltheria anorlana, Commelina coelestis and Alternanthera repens. J Ethnopharmacol 1988; 61: 41- 7.
  • Robert A, Nezamis JF, Lancaster C, Hanchar AJ, Klepper MS. Enteropooling assay: a test for diarrhea produced by prostaglandins. Prostaglandins 1976; 11:809-28.
  • Rao VSN, Santos FA, Sabreira TT, Souza MF, Melo CL, Silveria ER. Investigations on the gastroprotective and antidiarrhoeal properties of ternatin, a tetramethoxyflavone from Egletes viscosa. Planta Medica 1997;63:146-9
  • Ammon PJ, Thomas, Philips S. Effects of oleic acid and ricinolic net jejuna water and electrolyte movement. J Clin Invest 1974; 53:374-9. Tripathi KD. Essentials of Medical Pharmacology. New Delhi: Jaypee Brothers Medical Publishers (P); 1994.

ORIGINAL RESEARCH

Yıl 2014, Cilt: 18 Sayı: 3, 135 - 138, 12.09.2014

Öz

Bu çalışmanın amacı, sıçanlarda deneysel olarak oluşturulan diyareye karşı Ficus microcarpa ekstresinin antidiyareik etkinliğini araştırmaktır. Deneylerde Albino sıçanlar kullanıldı. Antidiyareik aktivite hint yağı ile oluşturulan diyare modelinde çalışıldı. 300 mg/kg ve 600 mg/kg dozlarında Ficus microcarpa ekstresi sıçanlarda anlamlı bir anti diyareik etki gösterdi. Toplam ıslak dışkı sayısı hint yağı grubuna (20.75) göre ekstre tedavisi uygulanan gruplarda her iki dozda önemli ölçüde (P <0.05; 300 mg/kg ‘de 4.31 ve 600 mg/kg dozunda 7.16) azaldı. Ficus microcarpa ekstresinin anti- enteropooling etkinliğe sahip

Kaynakça

  • Mani M, Sachan N, Tandon A, Wahi AK. Anti-diarrheal activity of methanolic extract of root bark of Ailanthus altissima Swingle (Family: Simaroubaceae) on experimental animals. Int J Pharm Sci Res 2010;1:197-202.
  • Park K. Park’s Textbook of preventive and social medicine. Jabalpur, India: M/S Banarsidas Bharat Publishes; 2000;172-5.
  • Mohammed A, Ahmed H, Goji ADT, Okpanachi AO, Ezekiel I, Tanko Y. Preliminary Anti-diarrheal Activity of Hydromethanolic Extract of Aerial Part of Indigofera pulchra in Rodents. Asian J Med Sci; 2009; 1: 22-5.
  • Wagner WL, Herbst DR, Sohmer SH. Manual of the Flowering Plants of Hawaii. 2 nd ed. Honolulu: University of Hawaii and Bishop Museum Press; 1999.
  • Warrier PK, Nambiar VPK, Ramankutty C. Indian Medicinal Plants a Compendium of 500 Species.3 rd ed. Madras: Orient Longman; 1995.
  • Chiang YM, Chang JY, Kuo CC. Cytotoxic triterpenes from the aerial roots of Ficus microcarpa. J Phytochemistry 2005; 66: 495-501.
  • Taira T, Ohdomari A, Nakama N,Shimoji M, Ishihara M. Characterization and antifungal activity of gazyumaru (Ficus microcarpa) latex chitinase: Both the chitin-binding and the antifungal activities of class 1 chitinase are reinforced with increasing ionic strength. Biosci Biotechnol Biochem 2005; 69: 811-8.
  • Nasrin A, Iran R, Amir M. Hepatoprotective Activity of Capparis spinosa Root Bark Against CCl4 Induced Hepatic Damage in Mice. Iranian Journal of Pharmaceutical Research 2007; 6: 285-90.
  • Trease G.E. and W.C. Evans. Textbook of Pharmacognosy. 15th Edn. London: Bailliere Tindal;2006,135-9.
  • Hilaly JE, Israili Z.H, Lyoussi B. Acute and chronic toxicological studies of Ajuga iva in experimental animals. J Ethnopharmacol 2004; 91: 43-50.
  • Doherty SS. Inhibition of arachinodic acid release, mechanism by which glucocorticoids inhibit endotoxin-induced diarrhea. British J Pharmacol 1981; 73: 549-54.
  • Zaval MA, Pera ZS, Perez P, Vargan R, Perz RM. Antidiarrheal activity of Waltheria anorlana, Commelina coelestis and Alternanthera repens. J Ethnopharmacol 1988; 61: 41- 7.
  • Robert A, Nezamis JF, Lancaster C, Hanchar AJ, Klepper MS. Enteropooling assay: a test for diarrhea produced by prostaglandins. Prostaglandins 1976; 11:809-28.
  • Rao VSN, Santos FA, Sabreira TT, Souza MF, Melo CL, Silveria ER. Investigations on the gastroprotective and antidiarrhoeal properties of ternatin, a tetramethoxyflavone from Egletes viscosa. Planta Medica 1997;63:146-9
  • Ammon PJ, Thomas, Philips S. Effects of oleic acid and ricinolic net jejuna water and electrolyte movement. J Clin Invest 1974; 53:374-9. Tripathi KD. Essentials of Medical Pharmacology. New Delhi: Jaypee Brothers Medical Publishers (P); 1994.
Toplam 15 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Makaleler
Yazarlar

Shripad Baıragı

Abhijeet Aher Bu kişi benim

Nitin Nema Bu kişi benim

Inayat Pathan Bu kişi benim

Yayımlanma Tarihi 12 Eylül 2014
Yayımlandığı Sayı Yıl 2014 Cilt: 18 Sayı: 3

Kaynak Göster

APA Baıragı, S., Aher, A., Nema, N., Pathan, I. (2014). Evaluation of Anti-Diarrhoeal Activity of the Leaves Extract of Ficus Microcarpa L. (Moraceae). Marmara Pharmaceutical Journal, 18(3), 135-138. https://doi.org/10.12991/mpj.2014187240
AMA Baıragı S, Aher A, Nema N, Pathan I. Evaluation of Anti-Diarrhoeal Activity of the Leaves Extract of Ficus Microcarpa L. (Moraceae). mpj. Kasım 2014;18(3):135-138. doi:10.12991/mpj.2014187240
Chicago Baıragı, Shripad, Abhijeet Aher, Nitin Nema, ve Inayat Pathan. “Evaluation of Anti-Diarrhoeal Activity of the Leaves Extract of Ficus Microcarpa L. (Moraceae)”. Marmara Pharmaceutical Journal 18, sy. 3 (Kasım 2014): 135-38. https://doi.org/10.12991/mpj.2014187240.
EndNote Baıragı S, Aher A, Nema N, Pathan I (01 Kasım 2014) Evaluation of Anti-Diarrhoeal Activity of the Leaves Extract of Ficus Microcarpa L. (Moraceae). Marmara Pharmaceutical Journal 18 3 135–138.
IEEE S. Baıragı, A. Aher, N. Nema, ve I. Pathan, “Evaluation of Anti-Diarrhoeal Activity of the Leaves Extract of Ficus Microcarpa L. (Moraceae)”, mpj, c. 18, sy. 3, ss. 135–138, 2014, doi: 10.12991/mpj.2014187240.
ISNAD Baıragı, Shripad vd. “Evaluation of Anti-Diarrhoeal Activity of the Leaves Extract of Ficus Microcarpa L. (Moraceae)”. Marmara Pharmaceutical Journal 18/3 (Kasım 2014), 135-138. https://doi.org/10.12991/mpj.2014187240.
JAMA Baıragı S, Aher A, Nema N, Pathan I. Evaluation of Anti-Diarrhoeal Activity of the Leaves Extract of Ficus Microcarpa L. (Moraceae). mpj. 2014;18:135–138.
MLA Baıragı, Shripad vd. “Evaluation of Anti-Diarrhoeal Activity of the Leaves Extract of Ficus Microcarpa L. (Moraceae)”. Marmara Pharmaceutical Journal, c. 18, sy. 3, 2014, ss. 135-8, doi:10.12991/mpj.2014187240.
Vancouver Baıragı S, Aher A, Nema N, Pathan I. Evaluation of Anti-Diarrhoeal Activity of the Leaves Extract of Ficus Microcarpa L. (Moraceae). mpj. 2014;18(3):135-8.