Transdermal delivery of ethosomes as a novel vesicular carrier for paroxetine hydrochloride: In vitro evaluation and In vivo study
Öz
Kaynakça
- grieswith bach Conference: Liposome Dermatics. editors: Braun-Falco O, Kortung HC, Maibach HI. Springer-Verlag, Berlin, Heidelberg. 1992.
- touitou e, Junginger He, Weiner ND, Mezei M. Liposomes as carriers for topical and transdermal delivery. J Pharm Sci 1992; 9: 1189–1203.
- Hollister Le. a Lange Medical Book: Basic and Clinical Pharmacology. appleton and Lange, Norwalk, Connecticut. 1995, pp 448–459.
Transdermal delivery of ethosomes as a novel vesicular carrier for paroxetine hydrochloride: In vitro evaluation and In vivo study
Öz
The aim of the present work was to develop, characterisation of stable ethosomal formulation as a carrier for transdermal delivery of paroxetine hydrochloride. To prepare this ethosome different concentration of soya lecithin and ethanol was taken. Vesicular size, polydispersity index, zeta potential, entrapment effiency was determined by photon correlation spectroscopy and ultracentrifugation techniques. The in vitro permeation study across human cadaver skin was done. Stability study was done on optimised F2 formulation. The vesicle size decreases as an increase in the concentration of ethanol. Entrapment efficiency increase with increase in concentration of soya lecithin. The ethosome exhibit entrapment efficiency of 40-64%. In vitro permeation study across human skin ethosome F2 formulation showed higher transdermal flux 29.64%µg/cm2/hr. The release mechanism of in vitro permeation shows zero order drug release from the formulation. In vivo pharmacodyanamic study F2 formulation showed significant immobility as compared to control group. Stability study results revealed no significant change found in vesicle size distribution and polydispersity index. Our result indicates that the developed ethosomal system may be potential and safe to delivery paroxetine hydrochloride through transdermal delivery.
Anahtar Kelimeler
ethosome transdermal Paroxetine hydrochloride Soya lecithin Cholesterol
Kaynakça
- grieswith bach Conference: Liposome Dermatics. editors: Braun-Falco O, Kortung HC, Maibach HI. Springer-Verlag, Berlin, Heidelberg. 1992.
- touitou e, Junginger He, Weiner ND, Mezei M. Liposomes as carriers for topical and transdermal delivery. J Pharm Sci 1992; 9: 1189–1203.
- Hollister Le. a Lange Medical Book: Basic and Clinical Pharmacology. appleton and Lange, Norwalk, Connecticut. 1995, pp 448–459.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Bölüm | Makaleler |
| Yazarlar | |
| Yayımlanma Tarihi | 10 Ağustos 2015 |
| Yayımlandığı Sayı | Yıl 2016 Cilt: 20 Sayı: 1 |