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Formulation Design and In Vitro Evaluation of Carbamazepine Gastroretentive Floating Drug Delivery System for Oral Application

Year 2017, Volume: 21 Issue: 1, 59 - 66, 08.09.2016

Mohammad Salim Hossaın Md. Masud Kaisar Bhuıyan Sujan Banık , Md. Asif Hasan Md. Selim Reza

https://doi.org/10.12991/marupj.259882

Abstract

The objective of the study was to develop a gastroretentive floating drug delivery system containing Carbamazepine as a model drug with two hydrophilic polymers i.e. Methocel K4M and Carbomer 971. The effect of these polymers was evaluated in terms of physical characteristics, floating behavior and drug release.  Floating lag time was found to be 4-136 sec and total floating time was > 18 h depending on the formulations. Drug release was studied for 8 h. Simulated drug release pattern in different kinetic model suggests that the mechanism controlling of the drug release from all formulations was the anomalous or non-Fickian and Case II type release. Polymer with lower viscosity (HMPC K4M) was found to be beneficial than higher viscosity polymer (Carbopol 971) in improving the release properties of gastric floating drug delivery system. Incorporation of Carbopol also in formulation helped in maintaining buoyancy of system with desirable drug release. Further study is required in case of in vitro- in vivo correlation but the present study will help us to future scientists working in this area to effectively use the potential of this drug delivery system for the benefit of mankind. 

Keywords

Carbamazepine Methocel K4M Carbopol 971 Buoyancy GRDDS

Midede kalış süresini uzatan yüzen karbamazepin tabletlerinin formülasyonu ve in vitro değerlendirilmesi

Year 2017, Volume: 21 Issue: 1, 59 - 66, 08.09.2016

Mohammad Salim Hossaın Md. Masud Kaisar Bhuıyan Sujan Banık , Md. Asif Hasan Md. Selim Reza

https://doi.org/10.12991/marupj.259882

Abstract

Bu çalışmanın amacı, etken madde
olarak karbamazepin  içeren midede kalış
süresini uzatan yüzen bir model tablette 
Metosel K4M and Karbomer 971 gibi hidrofilik polimerlerin  etkinliklerinin değerlendirilmesidir.
Polimerlerin etkinlikleri;  fiziksel
özellikleri, şişme özellikleri, yüzme yetenekleri ve  ilaç salım profilleri açısından
değerlendirilmiştir. Tabletlerin  formülasyonlarına
bağlı olarak yüzmeye başlama öncesindeki 
gecikme süreleri 4-136 saniye, toplam yüzme süreleri 6-18  saat olarak bulunmuştur. Tabletlerden etken
madde salımı  8 saatlik bir zaman dilimi
için çalışılmıştır. Simulasyon ile  oluşturulan
farklı ilaç salım kinetik modelleri ile yapılan 
çalışmalar sonucunda; hazırlanan bütün formülasyonların ilaç  salım özelliklerinin özdeş olmadığı veya Fick
yasasına uymadığı  tespit edilmiştir.
Karbopol 971’in, Metosel K4M’ye kıyasla daha 
yüksek şişme kapasitesine sahip olması nedeniyle ilaç salım  süresini daha etkili şekilde uzattığı tespit
edilmiştir.  

Keywords

Karbamazepin Metosel K4M Karbopol 971 Yüzebilme özelliği GRDDS

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Details

Subjects Health Care Administration
Journal Section Articles
Authors

Mohammad Salim Hossaın This is me

Md. Masud Kaisar Bhuıyan This is me

Sujan Banık

Md. Asif Hasan This is me

Md. Selim Reza This is me

Publication Date September 8, 2016
Published in Issue Year 2017 Volume: 21 Issue: 1

Cite

APA Hossaın, M. S., Bhuıyan, M. M. K., Banık, S., Hasan, M. A., et al. (2016). Formulation Design and In Vitro Evaluation of Carbamazepine Gastroretentive Floating Drug Delivery System for Oral Application. Marmara Pharmaceutical Journal, 21(1), 59-66. https://doi.org/10.12991/marupj.259882
AMA Hossaın MS, Bhuıyan MMK, Banık S, Hasan MA, Reza MS. Formulation Design and In Vitro Evaluation of Carbamazepine Gastroretentive Floating Drug Delivery System for Oral Application. J Res Pharm. September 2016;21(1):59-66. doi:10.12991/marupj.259882
Chicago Hossaın, Mohammad Salim, Md. Masud Kaisar Bhuıyan, Sujan Banık, Md. Asif Hasan, and Md. Selim Reza. “Formulation Design and In Vitro Evaluation of Carbamazepine Gastroretentive Floating Drug Delivery System for Oral Application”. Marmara Pharmaceutical Journal 21, no. 1 (September 2016): 59-66. https://doi.org/10.12991/marupj.259882.
EndNote Hossaın MS, Bhuıyan MMK, Banık S, Hasan MA, Reza MS (September 1, 2016) Formulation Design and In Vitro Evaluation of Carbamazepine Gastroretentive Floating Drug Delivery System for Oral Application. Marmara Pharmaceutical Journal 21 1 59–66.
IEEE M. S. Hossaın, M. M. K. Bhuıyan, S. Banık, M. A. Hasan, and M. S. Reza, “Formulation Design and In Vitro Evaluation of Carbamazepine Gastroretentive Floating Drug Delivery System for Oral Application”, J Res Pharm, vol. 21, no. 1, pp. 59–66, 2016, doi: 10.12991/marupj.259882.
ISNAD Hossaın, Mohammad Salim et al. “Formulation Design and In Vitro Evaluation of Carbamazepine Gastroretentive Floating Drug Delivery System for Oral Application”. Marmara Pharmaceutical Journal 21/1 (September 2016), 59-66. https://doi.org/10.12991/marupj.259882.
JAMA Hossaın MS, Bhuıyan MMK, Banık S, Hasan MA, Reza MS. Formulation Design and In Vitro Evaluation of Carbamazepine Gastroretentive Floating Drug Delivery System for Oral Application. J Res Pharm. 2016;21:59–66.
MLA Hossaın, Mohammad Salim et al. “Formulation Design and In Vitro Evaluation of Carbamazepine Gastroretentive Floating Drug Delivery System for Oral Application”. Marmara Pharmaceutical Journal, vol. 21, no. 1, 2016, pp. 59-66, doi:10.12991/marupj.259882.
Vancouver Hossaın MS, Bhuıyan MMK, Banık S, Hasan MA, Reza MS. Formulation Design and In Vitro Evaluation of Carbamazepine Gastroretentive Floating Drug Delivery System for Oral Application. J Res Pharm. 2016;21(1):59-66.

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