Yıl 2013, Cilt 3 , Sayı 4, Sayfalar 220 - 228 2014-01-30

Medical use of squalene as a natural antioxidant
Doğal bir antioksidan olarak skualenin medikal kullanımı

Fatma Esra Güneş [1]


The aim of the present review is to emphasize the importance of squalene, a nutrient, in preventive and therapeutic medicine. Squalene is a triterpene that carries oxygen independent of the hemoglobin and it can carry oxygen directly to cell membranes throughout the body and reach the regions having low oxygen supply. Squalene has been reported to have an inhibitory effect on cancer promotion and a high anti-tumor activity; thus, it is primarily used as a supportive therapy in a variety of cancers. Epidemiological and experimental animal researches regarding squalene’s anti-cancer properties are interesting and promising. However, these properties of squalene should be supported by further extensive trials in humans.

Key words: Squalene, triterpene, cytotoxic activity, anti-tumor activity, skin disease, cholesterol metabolism
Bu derlemenin amacı, koruyucu ve tedavi edici tıp içerisinde skualenin yerini ve önemini vurgulamaktır. Skualen bir triterpen olup, hemoglobinden bağımsız olarak oksijeni hücreye doğrudan taşıyarak tüm vücuda ulaştırabilmektedir. Skualenin kanser oluşumunu önlediği ve yüksek anti-tümör aktivitesine sahip olduğu bildirilmiştir, bu nedenle, çeşitli kanserlerin tedavi sürecinde destekleyici olarak kullanılabilmektedir. Skualenin bu konu ile ilgili epidemiyolojik ve deneysel hayvan araştırmaları ilginç ve umut vericidir. Bununla birlikte, skualenin kimyasal özellikleri nedeniyle farklı hastalıkların tedavisinde kullanılması açısından, insanlarda daha geniş çalışmalarla desteklenmesi gerekmektedir.

Anahtar Kelimeler : Skualen, triterpen, sitotoksik aktivite, anti-tümor aktivite, deri hastalıkları, kolesterol metabolizması
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Yazar: Fatma Esra Güneş

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Yayımlanma Tarihi : 30 Ocak 2014

Bibtex @ { marusbed187215, journal = {Clinical and Experimental Health Sciences}, issn = {}, eissn = {2459-1459}, address = {}, publisher = {Marmara Üniversitesi}, year = {2014}, volume = {3}, pages = {220 - 228}, doi = {}, title = {Doğal bir antioksidan olarak skualenin medikal kullanımı}, key = {cite}, author = {Güneş, Fatma Esra} }
APA Güneş, F . (2014). Doğal bir antioksidan olarak skualenin medikal kullanımı. Clinical and Experimental Health Sciences , 3 (4) , 220-228 . Retrieved from https://dergipark.org.tr/tr/pub/marusbed/issue/17856/187215
MLA Güneş, F . "Doğal bir antioksidan olarak skualenin medikal kullanımı". Clinical and Experimental Health Sciences 3 (2014 ): 220-228 <https://dergipark.org.tr/tr/pub/marusbed/issue/17856/187215>
Chicago Güneş, F . "Doğal bir antioksidan olarak skualenin medikal kullanımı". Clinical and Experimental Health Sciences 3 (2014 ): 220-228
RIS TY - JOUR T1 - Doğal bir antioksidan olarak skualenin medikal kullanımı AU - Fatma Esra Güneş Y1 - 2014 PY - 2014 N1 - DO - T2 - Clinical and Experimental Health Sciences JF - Journal JO - JOR SP - 220 EP - 228 VL - 3 IS - 4 SN - -2459-1459 M3 - UR - Y2 - 2020 ER -
EndNote %0 Clinical and Experimental Health Sciences Doğal bir antioksidan olarak skualenin medikal kullanımı %A Fatma Esra Güneş %T Doğal bir antioksidan olarak skualenin medikal kullanımı %D 2014 %J Clinical and Experimental Health Sciences %P -2459-1459 %V 3 %N 4 %R %U
ISNAD Güneş, Fatma Esra . "Doğal bir antioksidan olarak skualenin medikal kullanımı". Clinical and Experimental Health Sciences 3 / 4 (Ocak 2014): 220-228 .
AMA Güneş F . Doğal bir antioksidan olarak skualenin medikal kullanımı. Clinical and Experimental Health Sciences. 2014; 3(4): 220-228.
Vancouver Güneş F . Doğal bir antioksidan olarak skualenin medikal kullanımı. Clinical and Experimental Health Sciences. 2014; 3(4): 228-220.