Evaluation of The Relationship Between Apelin 36 and Oxidative Stress In Patients With General Anxiety Disorder

İlkay Bahçeci; Umut Serkan Söztanacı; Meltem Puşuroğlu; Nuray Arslan; Ömer Faruk Duran; Bulent Bahceci; Zihni Acar Yazıcı

doi:10.19127/mbsjohs.1024605

EN

Evaluation of The Relationship Between Apelin 36 and Oxidative Stress In Patients With General Anxiety Disorder

Abstract

Objective: The aim of this study was to evaluate the relationship between apelin-36 and oxidative parameters and Generalized Anxiety Disorder (GAD). Apelin which prevents hippocampal neuronal death is an endogenous ligand for G protein bound APJ receptors in the central nervous system. Oxidative Stress were occurred by free radicals which caused apoptosis in the hypothlamus, hippocampus and amygdala regions of the Central Nervous System (CNS).
Methods: In this study, 61 patients diagnosed generalized anxiety disorder at psychiatry polyclinic and 55 control subjects were enrolled. The Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) and the Hamilton Anxiety Rating Scale (HARS) were used in this study and they were filled by the patients and healthy individuals. Serum apelin-36 level was measured by using an ELISA kit. Total antioxidant status (TAS) and Total Oxidant Status (TOS) in the serum was measured by an automated system. The data were analyzed by using the SPSS.
Results: It was found that serum apelin-36, TOS and Oxidative stress index (OSI) levels were significantly lower in patients’ group than controls. In addition, negative correlation was detected between apelin 36 levels and HARS scores, TOS and OSI values in patients’ group. TAS values were found as similar between the patient and control group. There was no correlation between TAS and Apelin 36 in the patient group.
Conclusion: In this study it was found that serum apelin-36, TOS and OSI levels were low in GAD. According to the results, Apelin-36 and oxidative stress may play a role in the etiopathogenesis of Generalized Anxiety Disorder.

Keywords

Apelin 36, , General Anxiety Disorder,, Oxidative stress,, Total antioxidant status,, total oxidant status

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

İlkay Bahçeci ^*
0000-0003-3662-1629
Türkiye

Umut Serkan Söztanacı
0000-0002-7100-9067
Türkiye

Meltem Puşuroğlu
0000-0002-1970-3262
Türkiye

Nuray Arslan
0000-0002-5893-1452
Türkiye

Ömer Faruk Duran
0000-0003-1936-128X
Türkiye

Bulent Bahceci
0000-0002-7591-3643
Türkiye

Zihni Acar Yazıcı
0000-0003-1603-6545
Türkiye

Publication Date

December 31, 2021

Submission Date

November 18, 2021

Acceptance Date

December 13, 2021

Published in Issue

Year 2021 Volume: 7 Number: 3

DOI

https://doi.org/10.19127/mbsjohs.1024605

IZ

https://izlik.org/JA75UJ98GZ

APA

Bahçeci, İ., Söztanacı, U. S., Puşuroğlu, M., Arslan, N., Duran, Ö. F., Bahceci, B., & Yazıcı, Z. A. (2021). Evaluation of The Relationship Between Apelin 36 and Oxidative Stress In Patients With General Anxiety Disorder. Middle Black Sea Journal of Health Science, 7(3), 397-403. https://doi.org/10.19127/mbsjohs.1024605

AMA

1.Bahçeci İ, Söztanacı US, Puşuroğlu M, et al. Evaluation of The Relationship Between Apelin 36 and Oxidative Stress In Patients With General Anxiety Disorder. Mid Blac Sea J Health Sci. 2021;7(3):397-403. doi:10.19127/mbsjohs.1024605

Chicago

Bahçeci, İlkay, Umut Serkan Söztanacı, Meltem Puşuroğlu, et al. 2021. “Evaluation of The Relationship Between Apelin 36 and Oxidative Stress In Patients With General Anxiety Disorder”. Middle Black Sea Journal of Health Science 7 (3): 397-403. https://doi.org/10.19127/mbsjohs.1024605.

EndNote

Bahçeci İ, Söztanacı US, Puşuroğlu M, Arslan N, Duran ÖF, Bahceci B, Yazıcı ZA (December 1, 2021) Evaluation of The Relationship Between Apelin 36 and Oxidative Stress In Patients With General Anxiety Disorder. Middle Black Sea Journal of Health Science 7 3 397–403.

IEEE

[1]İ. Bahçeci et al., “Evaluation of The Relationship Between Apelin 36 and Oxidative Stress In Patients With General Anxiety Disorder”, Mid Blac Sea J Health Sci, vol. 7, no. 3, pp. 397–403, Dec. 2021, doi: 10.19127/mbsjohs.1024605.

ISNAD

Bahçeci, İlkay - Söztanacı, Umut Serkan - Puşuroğlu, Meltem - Arslan, Nuray - Duran, Ömer Faruk - Bahceci, Bulent - Yazıcı, Zihni Acar. “Evaluation of The Relationship Between Apelin 36 and Oxidative Stress In Patients With General Anxiety Disorder”. Middle Black Sea Journal of Health Science 7/3 (December 1, 2021): 397-403. https://doi.org/10.19127/mbsjohs.1024605.

JAMA

1.Bahçeci İ, Söztanacı US, Puşuroğlu M, Arslan N, Duran ÖF, Bahceci B, Yazıcı ZA. Evaluation of The Relationship Between Apelin 36 and Oxidative Stress In Patients With General Anxiety Disorder. Mid Blac Sea J Health Sci. 2021;7:397–403.

MLA

Bahçeci, İlkay, et al. “Evaluation of The Relationship Between Apelin 36 and Oxidative Stress In Patients With General Anxiety Disorder”. Middle Black Sea Journal of Health Science, vol. 7, no. 3, Dec. 2021, pp. 397-03, doi:10.19127/mbsjohs.1024605.

Vancouver

1.İlkay Bahçeci, Umut Serkan Söztanacı, Meltem Puşuroğlu, Nuray Arslan, Ömer Faruk Duran, Bulent Bahceci, Zihni Acar Yazıcı. Evaluation of The Relationship Between Apelin 36 and Oxidative Stress In Patients With General Anxiety Disorder. Mid Blac Sea J Health Sci. 2021 Dec. 1;7(3):397-403. doi:10.19127/mbsjohs.1024605

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Oxidative Imbalance in Pediatric Anxiety Disorders: A Preliminary Comparative Study

Cureus

https://doi.org/10.7759/cureus.54796