The Effect of Intracranial Hemorrhage and SARS-CoV-2 Association on Mortality
Abstract
Methods: This study is a single-center retrospective cohort study. Patients who applied to Afyonkarahisar State Hospital between June 2020 and June 2021, who were evaluated as SARS-CoV-2 in their current state and who were found to have an intracranial hemorrhage, were evaluated.
Results: Of the 13 patients in our cohort, 7 (54%) had comorbidities such as hypertension, diabetes mellitus, and chronic renal failure. The intraparenchymal hematoma was observed in 5 patients, chronic subdural hematoma in 2 patients, acute subdural hematoma in 1 patient, and subarachnoid hemorrhage in 4 patients. Decompressive craniectomy and hematoma evacuation were performed on 5 patients in our study. Nine of the patients included in our study died as a result of their follow-up and treatment in the intensive care unit, and the mortality rate was 69%.
Conclusion: Intracranial hemorrhages may occur rarely in patients with SARS-CoV-2 infection, and it is observed that intracerebral hemorrhages, which are already quite mortal, are more mortal. In addition, COVID-19 infection is thought to be a risk factor for intracranial hemorrhages.
Keywords
Intracranial hemorrhages , anticoagulants , covid-19 , mortality
References
- 1. Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, et al. Neurologic Manifestations of Hospitalized Patients with Coronavirus Disease 2019 in Wuhan, China. JAMA Neurol. 2020;77(6):683-690. doi:10.1001/jamaneurol.2020.1127
- 2. Unüvar A. COVID-19 and Coagulopathy COVID-19 and Coagulopathy COVID-19 Associated Coagulopathy. Journal of Health Science Advanced Studies. 2020;3:53-62. doi:10.26650/JARHS2020-S1-0007
- 3. Sharifi-Razavi A, Karimi N, Rouhani N. COVID-19 and intracerebral haemorrhage: causative or coincidental? New Microbes New Infect. 2020;35:0-1. doi:10.1016/j.nmni.2020.100669
- 4. Benger M, Williams O, Siddiqui J, Sztriha L. Intracerebral haemorrhage and COVID-19: Clinical characteristics from a case series. Brain Behav Immun. 2020;88(June):940-944. doi:10.1016/j.bbi.2020.06.005
- 5. Thachil J, Tang N, Gando S, Falanga A, Jattaneo M, Levi M, et al. ISTH interim guidance on recognition and management of coagulopathy in COVID-19. J Thromb Haemost. 2020;18(5):1023-1026. doi:10.1111/jth.14810
- 6. Dogra S, Jain R, Cao M, Bilaloglu S, Zagzag D, Hochman S, et al. Hemorrhagic stroke and anticoagulation in COVID-19. J Stroke Cerebrovasc Dis. 2020;29(8):104984. doi:10.1016/j.jstrokecerebrovasdis.2020.104984
- 7. Rymer MM. Hemorrhagic stroke: intracerebral hemorrhage. Mo Med. 2011;108(1):50-54.
- 8. Cheruiyot I, Sehmi P, Ominde B, Bundi P, Mislani M, Ngure B, et al. Intracranial hemorrhage in coronavirus disease 2019 (COVID-19) patients. Neurol Sci. 2021;42(1):25-33. doi:10.1007/s10072-020-04870-z
- 9. Prokop M, Everdingen W Van, Vellinga T van R, Ufford HQ Van, Stöger L, Beenen L, et al. CO-RADS-A categorical CT assessment scheme for patients with suspected COVID-19: definition and evaluation original research. Radiology. 2020;(1):1-37.
- 10. Jaergere T, Krdzalic J, Fasen B, Kwee R. Radiological Society of North America Chest Classification System for Reporting COVID-19 Pneumonia: Interobserver Variability and Correlation with RT-PCR. Radiol Cardiothorac Imaging. Published online 2020. https://doi.org/10.1148/ryct.2020200213