Weight Drop Models in Traumatic Brain Injury

Güven Akçay

doi:10.19127/mbsjohs.1187145

EN

Weight Drop Models in Traumatic Brain Injury

Abstract

Traumatic brain injury (TBI) is the leading cause of morbidity and mortality worldwide. TBI is often seen in people with loss of motor, cognitive and sensory function. TBI causes serious health problems such as death, disability and mental disorders. TBI continues to be an increasing health problem all over the world. It is estimated that approximately 1.7 million people suffer from head trauma each year and approximately 50,000 of these individuals die. Although TBI is seen in all ages and populations, the age population with the highest incidence is children and the elderly. Falls, sports activities and motor vehicle accidents are the biggest risk factors for TBI. To develop diagnosis and treatment methods for traumatic brain injury, the molecular and cellular mechanisms underlying neuropathology should be known. Therefore, different models of mild, moderate and severe experimental traumatic brain injury models are used. Animal models of traumatic brain injury are broadly classified as focal, diffuse, and mixed injury. Fluid percussion, controlled cortical effect, weight reduction and blast wave are the most preferred models in traumatic brain injury experimental research. This review describes the strengths and weaknesses of current rodent models for traumatic brain injury.

Keywords

Experimental Traumatic Brain Injury Models, Weight Drop, Animal Models

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Review

Authors

Güven Akçay ^*
0000-0003-3418-8825
Türkiye

Publication Date

May 31, 2023

Submission Date

October 10, 2022

Acceptance Date

January 5, 2023

Published in Issue

Year 2023 Volume: 9 Number: 2

DOI

https://doi.org/10.19127/mbsjohs.1187145

IZ

https://izlik.org/JA34HL77XJ

APA

Akçay, G. (2023). Weight Drop Models in Traumatic Brain Injury. Middle Black Sea Journal of Health Science, 9(2), 375-384. https://doi.org/10.19127/mbsjohs.1187145

AMA

1.Akçay G. Weight Drop Models in Traumatic Brain Injury. Mid Blac Sea J Health Sci. 2023;9(2):375-384. doi:10.19127/mbsjohs.1187145

Chicago

Akçay, Güven. 2023. “Weight Drop Models in Traumatic Brain Injury”. Middle Black Sea Journal of Health Science 9 (2): 375-84. https://doi.org/10.19127/mbsjohs.1187145.

EndNote

Akçay G (May 1, 2023) Weight Drop Models in Traumatic Brain Injury. Middle Black Sea Journal of Health Science 9 2 375–384.

IEEE

[1]G. Akçay, “Weight Drop Models in Traumatic Brain Injury”, Mid Blac Sea J Health Sci, vol. 9, no. 2, pp. 375–384, May 2023, doi: 10.19127/mbsjohs.1187145.

ISNAD

Akçay, Güven. “Weight Drop Models in Traumatic Brain Injury”. Middle Black Sea Journal of Health Science 9/2 (May 1, 2023): 375-384. https://doi.org/10.19127/mbsjohs.1187145.

JAMA

1.Akçay G. Weight Drop Models in Traumatic Brain Injury. Mid Blac Sea J Health Sci. 2023;9:375–384.

MLA

Akçay, Güven. “Weight Drop Models in Traumatic Brain Injury”. Middle Black Sea Journal of Health Science, vol. 9, no. 2, May 2023, pp. 375-84, doi:10.19127/mbsjohs.1187145.

Vancouver

1.Güven Akçay. Weight Drop Models in Traumatic Brain Injury. Mid Blac Sea J Health Sci. 2023 May 1;9(2):375-84. doi:10.19127/mbsjohs.1187145