Relationship Between Abdominal Aortic Aneurysm and Inflammatory Markers
Abstract
Objective: In this study, we aimed to investigate the relationship between abdominal aortic aneurysm and systemic immune inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and other inflammatory markers, especially those derived from complete blood count.
Methods: Retrospectively, 72 consecutive patients admitted to our clinic for Abdominal Endovascular Aneurysm Repair (EVAR) for abdominal aortic aneurysm (AAA) between January 2019 and January 2022 were included in the study. Routine blood samples were taken before EVAR operation. NLR, PLR, SII of the patients were calculated and, RDW, Mean Platelet Volume (MPV), C-reactive protein values and other laboratory tests were recorded. They were compared with an age-matched control group.
Results: The age of the patients included in the study was 67.7 ± 10.6 years and the majority were male. The frequency of hypertension and coronary artery disease was also higher. In the comparison of hematologic parameters with the control group, MPV was 10.4(9.6-11.2) versus 9.5(8.6-10.1), p<0.001; CRP was 5(1.625-42.135) versus 3.21(2.08-4.75), p=0.04, NLR was 3.46(2.15-6.69) versus 2.29(1.65-2.78), p<0.001. SII was 682.54(417.08-1522.72) versus 558.22(405.33-711.31), p=0.02. The most significant association with the presence of ascending aortic aneurysm was observed between NLR.
Conclusion: Inflammatory markers, CRP, SII, NLR, MPV are significantly higher in patients with AAA. In patients with AAA, the association between aneurysm and NLR appears to be better. When following up these patients, it may be especially useful to look at CRP, SII, NLR, MPV levels.
Keywords
Aortic Aneurysm, Systemic İmmune İnflammation İndex, Neurophil Lymphocyte Ratio
Ethical Statement
:Ethics committee approval was received for this study from 23.06.2023 Clinical Research Ethics Committee of Ordu University.
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