Hematological and Inflammatory Parameters to Predict the Develop Surgical Site Infection After Cesarean Section
Abstract
Objective: This study seeks to illustrate the efficacy of inflammatory hematological markers in patients who develop site infections following a cesarean section, while also establishing reference values for these parameters.
Methods: This retrospective, single-center study was conducted at Ordu University Training and Research Hospital from January 2016 to January 2023. A comparison was made between 42 cases where surgical site infection developed after cesarean section and 42 cases. The data for this study were obtained from hospital medical records, which encompass of demographic, general medical, obstetric, and neonatal information. Preoperative complete blood count (CBC) was included in the analysis.
Results: Statistically significant differences were observed among preoperative hematological and inflammation markers, including "PLT, WBC, NOT, PCT, MLR, DNLR, NLO, PLO, MPVPR, LP, RDWPR, NLRNPR, SII. ROC analysis revealed that optimal cutoff values were statistically significant for most laboratory parameters and blood count-derived ratios in patients with post-Cesarean wound infection. The largest AUC for SII was 0.861 with the cut-off value of 892.03 (sensivity %76 and specifity %76).
Conclusion: This article has revealed differences between hematological and inflammatory markers in patients developing complications at the incision site after cesarean section. To assess the risk of surgical site infection development and reduce morbidity and hospitalization durations, further research in this area is needed.
Keywords
References
- Boley JP. The history of caesarean section. CMAJ 1991;145(4):319–22.
- Hammad IA, Chauhan SP, Magann EF, Alfred Z. Peripartum complications with cesarean delivery: a review of Maternal-Fetal Medicine Units Network publications. J Matern Fetal Neonatal Med 2014;7058, doi:http://dx.doi.org/ 10.3109/14767058.2013.818970.
- Conroy K, Koenig AF, Yu Y, Courtney A, Lee HJ, Norwitz ER. Infectious morbidity after cesarean delivery: 10 strategies to reduce risk. Rev Obstet Gynecol 2012;5 (2):69–77, doi:http://dx.doi.org/10.3909/riog0188.
- Wloch C, Wilson J, Lamagni T, Harrington P, Charlett A, Sheridan E. Risk factors for surgical site infection following caesarean section in England: results from a multicentre cohort study. BJOG 2012;1324–33, doi:http://dx.doi.org/10.1111/ j.1471-0528.2012.03452.x.
- Nabhan AF, Allam NE, Hamed Abdel-Aziz Salama M. Routes of administration of antibiotic prophylaxis for preventing infection after caesarean section (Review). Cochrane Database Syst Rev 2016;17(6), doi:http://dx.doi.org/ 10.1002/14651858.CD011876.pub2.www.cochranelibrary.com.
- Balta S, Ozturk C, Balta S, Ozturk C. The platelet-lymphocyte ratio: a simple, inexpensive and rapid prognostic marker for cardiovascular events. Platelets 2015;7104:2014–6, doi:http://dx.doi.org/10.3109/09537104.2014.979340.
- Büyükavcı R, Aktürk SSS. Comparison of blood platelet distribution width and neutrophil-lymphocyte ratio in patients with different grades of knee osteoarthritis. J Back Musculoskelet Rehabil 2018;31(6):1035–9.
- Verit FF, Cetin O, Yildirim O, Neutrophil to lymphocyte ratio is superior to platelet to lymphocyte ratio as an early predictor of moderate/severe ovarian hyperstimulation syndrome. J Obstet Gynaecol 2014;3615, doi:http://dx.doi.org/10.3109/01443615.2014.920792.
- Kurtoglu E, Kokcu A, Celik H . May ratio of neutrophil to lymphocyte be useful in predicting the risk of developing preeclampsia? A pilot study. J Matern Fetal Neonatal Med 2015;7058, doi:http://dx.doi.org/10.3109/14767058.2014.905910.
- Sonmez, O., & Sonmez, M. Role of platelets in immune system and inflammation. Porto biomedical journal, 2017;2(6): 311-314.