Relationship Between BCL-2 and Ki-67 in Chronic Sialadenitis
Abstract
Objective: Apoptosis
or programmed cell death can be triggered by a variety of physiological and
pathological signals. B-cell lymphoma-2 (Bcl-2) is an important anti-apoptotic
protein of apoptosis pathways, mainly localized in intracellular membranes in
mitochondrial outer membrane nuclear membrane and endoplasmic reticulum. BCL-2
family molecules can be stocked by upstream with irreversible cellular damage
sites and have an important role in apoptosis studies. The best known antibody
for identifying proliferating cells is Ki-67. There is a clear correlation
between Ki-67 and the number of mitoses. Ki-67 is a nuclear protein that is
believed to play a role in the early stages of rRNA synthesis ex- pressed in
the G1, S, G2 and M phases except for the G0 phase of the cell cycle. In this
study, we evaluated the expression of BCL-2 and Ki-67 in the pathogenesis of
chronic sialadenitis.
Methods: This study
was included 18 cases of chronic sialadenitis. The immunohistochemistry BCL-2
and Ki-67 antibodies was performed in cases.
Results:
Statistically, there were significant correlation between BCL-2 and Ki-67
expression in acinar cells (p= 0.016). There was significant correlation
between BCL-2 and Ki-67 expression in ductus and epimyoepithelial islands (p=
0.017). There was significant correlation between ductal and acinar cells on
account of Ki-67 expression (p= 0.010).
Conclusion: In this
study, it was seen that decrease of BCL-2 and Ki-67 expression in acinar cells
was higher than ductal epithelial cells.
Keywords
BCL-2,Ki-67,chronic sialadenitis
