Comparison of Antibiotic Sensitivity Pattern of Escherichia coli which Produce Extended Spectrum Beta-Lactamase Strains Isolated From Various Clinical Specimens In Intensive Care Unit

Tuğba Cebeci; Dilek Keskin; Ahmet Ali Gökal

doi:10.19127/mbsjohs.525833

EN

Comparison of Antibiotic Sensitivity Pattern of Escherichia coli which Produce Extended Spectrum Beta-Lactamase Strains Isolated From Various Clinical Specimens In Intensive Care Unit

Abstract

Objective: A retrospective analysis of the widely used antibiotics all susceptibility testing results from Escherichia coli (E. coli) cultured from clinical specimens private hospital (from January 2017 to November 2018) was performed.

Methods: The VITEK 2 Compact automated microbiology system (bioMérieux) is designed for automated rapid antimicrobial susceptibility testing and identification of clinically relevant bacteria. Minimum inhibitory concentration (MIC) results previously obtained in recent clinical isolates with well-defined in isolates with well-characterized resistance mechanisms with the microdilution method were re-interpreted for the susceptible, intermediate and resistant categories using the 2018 EUCAST breakpoints. Clinical samples are most commonly isolated from blood, sputum and urine samples.

Results: The results of resistance pattern of E. coli isolates in our locality to antimicrobial agents showed that the 64 E. coli strains tested against fifteen antimicrobial agents. E. coli isolates were highly resistant to piperacillin, ceftazidime and aztreonam 98%, 61% and 61% respectively. The most sensitive antibiotics were colistin, tigecycline, imipenem and meropenem. In the present study, 73% (47) of the isolates were resistant to at least three to fourteen antibiotics. All of the isolates showed resistance to at least one antibiotics. Thirty nine per cent of E. coli isolates were extended spectrum beta-lactamase (ESBL) producers.

Conclusion: Considering the antibiogram, imipenem and meropenem should be preferred drugs for E. coli infection isolated from clinical samples.

Keywords

Esherichia coli,antibiotic sensitivity,clinical specimens,intensive care unit

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Tuğba Cebeci ^*
0000-0001-8960-0587
Türkiye

Dilek Keskin
Türkiye

Ahmet Ali Gökal This is me
Türkiye

Publication Date

April 28, 2019

Submission Date

February 13, 2019

Acceptance Date

April 4, 2019

Published in Issue

Year 2019 Volume: 5 Number: 1

DOI

https://doi.org/10.19127/mbsjohs.525833

IZ

https://izlik.org/JA32WZ55KB

Vancouver

1.Tuğba Cebeci, Dilek Keskin, Ahmet Ali Gökal. Comparison of Antibiotic Sensitivity Pattern of Escherichia coli which Produce Extended Spectrum Beta-Lactamase Strains Isolated From Various Clinical Specimens In Intensive Care Unit. Mid Blac Sea J Health Sci. 2019 Apr. 1;5(1):33-8. doi:10.19127/mbsjohs.525833

Comparison of Antibiotic Sensitivity Pattern of Escherichia coli which Produce Extended Spectrum Beta-Lactamase Strains Isolated From Various Clinical Specimens In Intensive Care Unit

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Comparison of Antibiotic Sensitivity Pattern of Escherichia coli which Produce Extended Spectrum Beta-Lactamase Strains Isolated From Various Clinical Specimens In Intensive Care Unit

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