Antimicrobial Resistance of Enterococcus Species Isolated from Urine Cultures
Abstract
Objective: Enterococcus spesies are among the common causes of nosocomial urinary tract infections mainly, along with other infections and have been observed to have increasing rates of resistance against antimicrobial agents in recent years. The aim of this study is to determine the Enterococcus spp. isolated from urine cultures in our hospital and to determine antibiotic resistance rates.
Methods: Enterococcus isolates identification and antibiogram results obtained from urine samples sent to Ordu University Education and Research Hospital Microbiology laboratory from inpatients and outpatients were retrospectively evaluated. The identification and antimicrobial susceptibility tests of the isolates were completed on a VITEK 2 Compact (Biomerieux, Marcy l'Etoile, France) system. Resistance rates against ampicillin, ciprofloxacin, nitrofurantoin, tigecycline, linezolid, teicoplanin and vancomycin were analyzed.
Results: Our study identified 346 Enterococcus strains. These strains were defined as 195 Enterococcus faecalis (56%), 127 Enterococcus faecium (37%) and 24 other enterococci (7%). The antimicrobials with highest resistance were ciprofloxacin (51%), ampicillin (42%), nitrofurantoin (14%) and tigecycline (1%), in order, with no resistance encountered for linezolid, teicoplanin and vancomycin.
Conclusion: Glycopeptide resistance were not encountered among enterococci isolated from urine cultures in our hospital, with qunolone resistance at the fore. The results of antimicrobial susceptibility tests are important to select appropriate treatments.
Keywords
References
- Agus N, Sarica A, Ozkalay N, Cengiz A. Antimicrobial Resistance of Enterococcus Strains Isolated from Clinical Specimens. ANKEM J. 2006;20(3):145-7.
- Aktepe OC, Asik G, Ciftci IH, Cetinkaya Z. Antibiotic Resistance Rates in Enterococcus Strains Isolated from Clinical Specimens. Turk Mikrobiyol Cem J 2011;41(2):86-90.
- Andriole VT. The Quinolones: Past, Present, and Future. Clinical Infectious Diseases. 2005;41(Supplement_2):113-9.
- Aykut Arca E, Mert Dinc B, Karabiber N. Distribution to Clinics of Enterococci Species Isolated from Various Clinical Samples. Turkish Bulletin of Hygiene and Experimental Biology. 2009;66(1):1-5.
- Baykan M. Evaluation of invitro antibiotic sensitivity of Enterococcus isolated from urine samples. Gen Med J. 2001;11(3):119-21.
- Butler KM. Enterococcal Infection in Children. Seminars in Pediatric Infectious Disease: 2006;17(3):128-39. Contreras GA, Munita JM, Arias CA. Novel Strategies for the Management of Vancomycin-Resistant Enterococcal Infections. Curr Infect Dis Rep. 2019;21(7):22.
- Dilek AR, Yildiz F, Dilek N, Bulut Y, Asci Toraman Z. In-vitro Activity of Linezolid Against Methicillin-resistant Staphylococcus aureus (MRSA) and Enterococcus spp. ANKEM J. 2007;21(4): 211-3.
- Etiz P, Kibar F, Ekenoglu Y, Yaman A. Evaluation of the Antibiotic Resistance Profiles of Enterococcus Species Isolated from Urine Cultures. Turk Mikrobiyol Cem Derg. 2014;44(3):107-13.
- Gonzales RD, Schreckenberger PC, Graham MB, Kelkar S, DenBesten K, Quinn JP. Infections due to vancomycin-resistant Enterococcus faecium resistant to linezolid. Lancet. 2001;357(9263):1179.
- Gordon S, Swenson JM, Hill BC, Pigott NE, Facklam RR, Cooksey RC et al. Antimicrobial susceptibility patterns of common and unusual species of enterococci causing infections in the United States. Enterococcal Study Group. J Clin Microbiol. 1992;30(9):2373-8.