Investigation of Thyroid Hormones and Prolactin Levels in Fertile and Infertile Women

Year 2016, Volume: 2 Issue: 1, 1 - 6, 27.04.2016

Arzu Şahin , Feyyaz Önder

https://doi.org/10.19127/mbsjohs.63680

Cited By: 1

Abstract

Objective: This study was conducted to investigate thyroid hormones and prolactin levels in fertile and infertile women.

Materials and Methods: The study enrolled a total of 84 women, 40 infertile and 44 fertile, aged between 15-45 years and applied to Kars Maternity and Child Hospital, Obstetrics Clinic and Artvin State Hospital, Obstetrics and Gynecology Clinic. The study population was divided into 3 groups: Group P (n=30, women having primary infertility), Group S (n=10, women having secondary infertility) and Group F (N=44, fertile women). Blood samples were obtained in early follicular phase and serum thyrotropin (TSH), free triiodothyronine (FT₃₎, free thyroxine (FT₄) and prolactin levels were determined by Microparticle Enzyme Immunoasay (MEIA) method.

Results: Serum TSH levels were 1.70±0.40, 1.60±0.20 and 0.80±0.20 µIU/ml for the groups F, P and S, respectively (p> 0.05).  FT₃ levels were 2.36±0.06, 2.46±0.09 and 2.35±0.2 pg/ml while FT₄ levels were 0.98±0.02, 0.94±0.04 and 1.00±0.03 ng/dl for the groups F, P and S, respectively. There was a significant negative correlation between TSH and FT₄ (p=0.012, r = -0.275) and a significant positive correlation between FT₃ and FT₄ (p=0.002, r = 0.330). Serum prolactin levels were measured as 16.70±2.60, 21.10± 2.10 and 16.00±1.90 ng/ml respectively for the groups F, P and S and no significant difference was detected between the groups with respect to prolactin levels (p >0.05).

Conclusion: As a result, there was no difference between the groups in terms of TSH, FT₃, FT₄ and prolactin levels. Hormone levels were generally within normal limits and therefore we determine no significant relationship between infertility and investigated parameters in this study.

Keywords

TSH, FT3, FT4, Prolactin, Infertility, Fertilty

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