Assessment of oxidative stress with thiol disulfide homeostasis and ischemia-modifıed albumin level in acute urticaria

Yıl 2021, Cilt: 7 Sayı: 1, 115 - 121, 30.04.2021

İsmail Erkan Aydın Şeyda Tuba Savrun Atakan Savrun Sevda Önder Salim Neşelioğlu Özcan Erel Yeliz Kaşko Arıcı

https://doi.org/10.19127/mbsjohs.908621

Cited By: 3

Öz

Objective: There is no study in the literature investigating ischemia-modified albumin (IMA) values and thiol disulfide homeostasis (TDH) parameters in acute urticaria patients. This study aimed assessment of TDH parameters and IMA in acute urticaria patients.
Methods: The study included a total of 68 cases, with 35 acute urticaria patients and 33 healthy volunteers. Patients who presented to Ordu University Hospital and were diagnosed with acute urticaria between January 2019 and June 2019 and healthy individuals as the control group were included in the study. Serum albumin, IMA, native thiol, total thiol, and disulfide thiol levels were measured, and the results were compared between the groups.
Results: IMA values of 0.93±0.09 in the study group were significantly high compared to 0.8±0.10 in the control group (p<0.01). Native thiol (SH) level was 353.66±87.5 in the study group, 393.62±47.7 in the control group (p:0.022), and total thiol (TSH) level was 385.46±86.6 in the study group and 433.53±56.06 in the control group (p:0.008). In the patient group there was a significant negative correlation between SH levels and IMA levels (r=-0.626, p<0.001).
Conclusion: In acute urticaria, IMA increases while SH and TSH levels reduce. However, TDH does not change. The lack of change in the balance may be explained by acute urticaria being an acute event and not being a chronic inflammatory process.

Anahtar Kelimeler

acute urticaria, thiol disulfide, ischemia-modified albumin, oxidative stress

Kaynakça

• 1. Goncu Kocaturk E, Aktan Ş, Atakan N, Başkan EB, Erdem T, Koca R, et al. The Turkish Guideline for the Diagnosis and Management of Urticaria-2016. Turkderm–ArchTurk Dermatol Venerology. 2016;50:82-98.
• 2. Kulthanan K, Chiawsirikajorn Y, Jiamton S. Acute urticaria: etiologies, clinical course and quality of life. Asian Pac J Allergy Immunol. 2008;26:1–9.
• 3. Akbas A, Kilinc F, Sener S, Aktaş A, Baran P, Ergin M, et al. Investigation of thiol-disulphide balance in patients with acute urticaria and chronic spontaneous urticaria. Cutan Ocul Toxicol. 2017;36(3):205-210.
• 4. Briganti S, Picardo M. Antioxidant activity, lipid peroxidation and skin diseases. What’s new? J Eur Acad Dermatol Venereol. 2003;17:663–669.
• 5. Bickers DR, Athar M. Oxidative stress in the pathogenesis of skin disease. J Invest Dermatol. 2006;126:2565–2575.
• 6. Korkmaz V, Kurdoglu Z, Alisik M, Cetin O, Korkmaz H, Surer H, et al. Impairment of thiol-disulfidehomeostasis in preeclampsia. J Matern Fetal Neonatal Med. 2016;29(23):3848-53.
• 7. Okayama Y. Oxidative stress in allergic and inflammatory skin diseases. Curr Drug Targets Inflamm Allergy. 2005;4:517–519.
• 8. Cassano N, De Meo M, Scoppio BM, Loviglio MC, Del Vecchio S, Vena G. A.Does oxidative stress play a role in the pathogenesis of urticarias? Eur J Inflamm. 2005;3:5–10.
• 9. Cichota LC, Moresco RN, Duarte MMMF, Silva JEPD. Evaluation of ischemia-modified albumin in anemia associated to chronic kidney disease. J Clin Lab Anal. 2008;22:1-5.
• 10. Raho G, Cassano N, D’Argento V, Vena GA, Zanotti F. Overexpression of Mn-superoxide dismutase as a marker of oxidative stress in lesional skin of chronic idiopathic urticaria. Clin Exp Dermatol. 2003;28:318–320.
• 11. Cassano N, Raho G, Filieri M, D’Argento V, Amoruso A, Filotico R, et al. Influence of desloratadine on oxidative stress markers in patients with chronic idiopathic urticaria. Int J Dermatol. 2006;45:394–396.
• 12. Kasperska-Zajac A, Brzoza Z, Rogala B, Polaniak R, Birkner E. Antioxidant enzyme activity and malondialdehyde concentration in the plasma and erythrocytes of patients with urticaria induced by nonsteroidal anti-inflammatory drugs. J Investig Allergol Clin Immunol. 2008;18:372–375.
• 13. Sagdic A, Sener O, Bulucu F, Karadurmus N, Yamanel L, Tasci C, et al. Oxidative stress status in patients with chronic idiopathic urticaria. Allergol Immunopathol (Madr). 2011;39:150–153.
• 14. Kalkan G, Seckin HY, Duygu F, Akbaş A, Özyurt H, Şahin M. Oxidative stress status in patients with acute urticaria. Cutan Ocul Toxicol. 2014;33:109–114.
• 15. Briganti S, Cristaudo A, D'argento V, Cassano N, Turbino L, Guarrera M, et al. Oxidative stress in physical urticarias. Clin Exp Dermatol. 2001;26:284–288.
• 16. Kasperska-Zajac A, Brzoza Z, Rogala B, Polaniak R, Birkner E. Antioxidant enzyme activity and malondialdehyde concentration in the plasma and erythrocytes of patients with urticaria induced by nonsteroidal anti-inflammatory drugs. J Investig Allergol Clin Immunol. 2008;18:372–375.
• 17. Mushtaq A, Khan MN, Khursheed R, Qureshi MS, Malik A, Zahid S, et al. Antioxidant enzyme activity and malondialdehyde concentration in patients with urticaria induced by non steroidal anti-inflammatory drugs. Ann Punjab Med Coll. 2012;6(2):110–114.
• 18. Knight JA. Review: free radicals, antioxidants, and the immune system. Ann Clin Lab. 2000;30:145–158.
• 19. Dilek F, Ozceker D, Ozkaya E, Guler N, Tamay Z, Kesgin S, et al. Oxidative Stress in Children with Chronic Spontaneous Urticaria. Oxid Med Cell Longev. 2016;2016:3831071.
• 20. Eren Y, Dirik E, Neselioglu S, Erel O. Oxidative stres and decreased thiol levels in patients with migraine: crosssectional study. Acta Neurol Belg. 2015;115:643–649.
• 21. Ates I, Ozkayar N, Inan B, Yilmaz FM, Topcuoglu C, Neselioglu S, et al. Dynamic thiol/disulphide homeostasis in patients with newly diagnosed primary hypertension. J Am Soc Hypertens. 2016;10(2):159-66.
• 22. Kundi H, Ates I, Kiziltunc E, Cetin, M, Cicekcioglu H, Neselioglu S, et al. A Novel oxidative stres marker in acute myocardial infarction; thiol/disulphide homeostasis. Am J Emerg Med. 2015;33:1567–1571.
• 23. Ozyazici S, Karateke F, Turan U, Kuvvetli A, Kilavuz H, Karakaya B, et al. A Novel Oxidative Stress Mediator in Acute Appendicitis: Thiol/Disulphide Homeostasis. Mediators Inflamm. 2016;2016:6761050.
• 24. Yilmaz OH, Bal C, Neselioglu S, Buyuksekerci M, Gunduzoz M, Eren F, et al. Thiol/disulphide homeostasis in asphalt workers. Arch Environ Occup Health. 2016;71:268–272.
• 25. Sbarouni E, Georgiadou P, Voudris V. Ischemia modified albumin changes – review and clinical implications. Clin Chem Lab Med. 2011;49(2):177-84.
• 26. Toker A, Karatas Z, Altın H, Karaarslan S, Cicekler H, Alp H.. Evaluation of serum ischemia modified albumin levels in acute rheumatic fever before and after therapy. Indian J Pediatr. 2014;81(2):120-5.
• 27. Can U, Yerlikaya FH, Yosunkaya S. Role of oxidative stress and serum lipid levels in stable chronic obstructive pulmonary disease. J Chin Med Assoc. 2015;78(12):702-8.
• 28. Kaplan M, Yuksel M, Ates I, Kilic ZMY, Kilic H, Kuzu U, et al. Is ischemia modified albumin a disease activity marker for inflammatory bowel diseases? J Gastroenterol Hepatol. 2016;31(6):1120-5.
• 29. Ozdemir M, Kivici A, Balevi A, Mevlitoğlu I, Peru C. Assessment of ischaemia- modified albumin level in patients with psoriasis. Clin Exp Dermatol. 2012;37:610-4.
• 30. Erem C, Suleyman AK, Civan N, Mentese A, Nuhoglu I, Uzun A, et al. Ischemia-modified albümin and malondialdehyde levels in patients with overt and subclinical hyperthyroidism: effects of treatment on oxidative stress. Endocr J. 2015;62:493-501.
• 31. Dadaci Z, Oncel M, Oncel Acir N, Sahin E, Borazan M. Oxidative stres parameters and serum magnesium levels in patients with seasonal allergic conjunctivitis. Cutan Ocul Toxicol. 2016;35(4):270-4.
• 32. Patella V, Incorvaia C, Minciullo PL, Oricchio C, Saitta S, Florio G, et al. Oxidative stress markers in patients with hymenoptera venom allergy. Allergy Asthma Proc. 2015;36:9–13.
• 33. Roy D, Quiles J, Gaze DC, Collinson P, Kaski JC, Baxter GF. Role of reactive oxygen species on the formation of the novel diagnostic marker ischaemia modified albumin. Heart Br Card Soc. 2006;92:113–114.
• 34. Borderie D, Allanore Y, Meune C, Devaux JY, Ekindjian OG, Kahan A. High ischemia-modified albumin concentration reflects oxidative stress but not myocardial involvement in systemic sclerosis. Clin Chem. 2004;50: 2190–2193.
• 35. Kaefer M, Piva SJ, De Carvalho JA, Da Silva DB, Becker AM, Coelho AC, et al. Association between ischemia modified albumin, inflammation and hyperglycemia in type 2 diabetes mellitus. Clin Biochem. 2010; 43:450–454.