Squamous Differentiation In Transitional Bladder Carcinomas And Its Correlation With Grade, Stage, DNA Content, And Prognosis

Year 2001, Volume: 2 Issue: 1, 17 - 20, 01.04.2001

Füruzan Kacar Elif Selek Cem Yeniyol Sedat Çiçek

Abstract

In this study, the correlation of squamous differentiation with tumor grade, stage, DNA content and
prognosis was investigated in tansitional cell carcinomas.
Materials and Methods: Cases of transitional cell carcinomas with squamous differentiation were histologically
graded, (Mostofi), clinically staged (AJCC), and DNA content of tumor cells were determined with flow
cytometry. These data were correlated with prognosis using Pearson chi square, Pearson correlation analysis and
Kaplan-Meier analysis.
Only 2 of 16 cases of grade I transitional cell carcinoma showed squamous differentiation. Among grade
III cases 8 of 14 showed squamous differentiation, while 6 cases didn't. Only 3 of 17 stage I cases showed
squamous differentiation; 14 cases didn't. Five of 11 stage II cases showed squamous differentiation; 6 cases
didn't. Two out of 2 cases of stage III transitionel cell carcinoma showed squamous differentiation. Out of 15
cases which had diploid DNA content, only 1 showed squamous differentiation while 14 didn't. Among 15 cases
with aneuploid DNA content, 9 had squamous differentiation; 6 cases didn't. During the 4 years follow up period,
only 1 of 20 cases of transitional cell carcinoma without squamous differentiation were fatal, while three of 10
cases with squamous differentiation were fatal.
While no direct correlation between squamous differentiation and survival could be demonstrated,
since there was a significant relation between squamous differentiation and stage (p<0.05, r=0.457), grade
(p<0.05, r=0.472) and DNA content (p<0.05, r=0.566), we believe that presence of squamous differentiation is an
important finding that has to be indicated in pathology reports.

Keywords

Squamous differentiation, bladder carcinoma, flowcytometry

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