Amaç:Bu çalışmada çeşitli klinik örneklerden izole edilen stafilokokların antibiyotik direncinin saptanması amaçlanmıştır. Yöntem:Çalışmaya, klasik yöntemlerle tanımlanan 274 Staphylococcus. aureus (S. aureus) ve 172 koagülaz negatif stafilokok kökeni alınmıştır. Antibiyotik direnci, penisilin, metisilin, eritromisin, klindamisin, kotrimoksazol, siprofloksasin, vankomisin ve fusidik aside karşı Kirby-Bauer disk difüzyon yöntemi ile araştırılmış, metisilin direncinin saptanmasında oksasilin diski kullanılmıştır. Bulgular:Toplam 274 Staphylococcus aureus kökeninin % 92.3'ü penisiline, %10.9'u metisiline, % 21.5 'i eritromisine, % 14.8'i klindamisine %15.8'i ko-trimoksazole, % 7.3'ü siprofloksasine, % 5.7'si fusidik aside dirençli bulunurken, 172 koagülaz negatif stafilokok kökeninin % 84.2'si penisiline, %38.8'i metisiline, % 54.8'i eritromisine, % 44.4'ü klindamisine, %42.2'si ko-trimoksazole, % 25'i siprofloksasine, % 28.1'i fusidik aside dirençli bulunmuştur. Vankomisin direncine rastlanmamıştır. Sonuç:Koagülaz negatif stafilokok kökenlerinin S. aureusa göre antibiyotiklere daha yüksek oranda dirençli ve tüm stafilokok kökenlerinin vankomisine duyarlı olduğu saptanmıştır
Objective:The aim of this study was to detect the antibiotic resistance of staphylococci strains which were
isolated from various clinical specimens.
Methods:This study included 274 Staphylococcus aureus (S. aureus) and 172 coagulase negative staphylococci
strains which were identified with classical methods. Antibiotic resistance of strains to penicilline, methicillin,
erythromycin, clindamycin, co-trimoxazole, ciprofloxacin, vancomycin and fucidic acid were investigated by
Kirby-Bauer disc diffusion method, while in the detection of methicilline resistance oxacilline discs were used.
Results:Among the 274 S. aureus strains, 92.3% were found resistant to penicilline, 10.9% to methicillin, 21.5%
to erythromycin 14.8% to clindamycin, 15.8% to co-trimoxazole, 7.3% to ciprofloxacin, 5.7% to fucidic acid.
Among 172 CNS strains 84.2% were found resistant to penicilline, 38.8% to methicillin, 54.8% to erythromycin,
44.4% to clindamycin, 42.2% to co-trimoxazole, 25% to ciprofloxacin and 28.1% to fucidic acid. Vancomycin
resistance was not detected
Conclusion:In this study we found that strains of coagulase negative staphylococci were much more resistant
than S. aureus to antibiotics and all staphylococci were susceptible to vancomycin
Staphylococus aureus coagulase negative staphylococci methicillin resistance antibioticresistance
Other ID | JA68GP94DY |
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Journal Section | Research Article |
Authors | |
Publication Date | December 1, 2001 |
Published in Issue | Year 2001 Volume: 2 Issue: 3 |