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AYDIN'DA BEHÇET HASTALIĞI DENEYİMİ: 67 HASTANIN RETROSPEKTİF DEĞERLENDİRİLMESİ

Year 2008, Volume: 9 Issue: 3, 21 - 26, 01.12.2008

Abstract

AMAÇ:Bu çalışmada Adnan Menderes Üniversitesi Tıp Fakültesi Dermatoloji AD'da izlenen Behçethastalarının demografik ve klinik özelliklerinin belirlenmesi amaçlandı.GEREÇ ve YÖNTEM:Çalışmaya uluslararası Behçet hastalığı tanı kriterlerini dolduran 67 hasta dahil edildi.Hastaların dosya bilgileri incelendi ve veriler SPSS 14 programı kullanılarak analiz edildi.BULGULAR:Yaşları 16 ile 61 arasında değişen hastaların yaş ortalaması 35.7±10.5'ti ve erkek/kadın oranı1.48:1 idi. Hastalığın ilk semptomunun başlama yaşı ortalaması 27.1±9.3, Behçet hastalığı tanısını alma yaşıortalaması 32.4±9.6'ydı. Oral ülserler (%100) ve genital ülserler (%97.0) hastalığın en sık bulguları idi. Bunlarıpapülopüstüler döküntü (%72.3), paterji pozitifliği (%50.8) eritema nodozum (%38.8), eklem tutulumu (%23.9),göz tutulumu (%21.5) ve tromboflebit (%9.1) izledi. Tromboflebit anlamlı olarak erkeklerde daha fazla görüldü(p=0.03).SONUÇ:Aydın'da tek merkezli olarak Dermatoloji kliniğinde izlenen Behçet hastalarının verileri sunuldu.Mukokutanöz bulguların ön planda olduğu hastaların hiçbirinde şiddetli tutulum izlenmedi

References

  • 1. Çakır N, Derviş E, Benian O, Pamuk ON, Sönmezateş N, Rahimoğlu R, Tuna S, Çetin T, Sarıkaya Y. Prevalence of Behçet's disease in rural western Turkey: a preliminary report. Clin Exp Rheumatol 2004; 22: 53- 5.
  • 2. Tüzün Y, Yurdakul S, Cem Mat M, Özyazgan Y, Hamuryudan V, Tüzün B, Yazıcı H. Epidemiology of Behçet's syndrome in Turkey. Int J Dermatol 1996; 35: 618-20.
  • 3. Yurdakul S, Günaydın I, Tüzün Y, Tankurt N, Pazarlı H, Özyazgan Y, Yazıcı H.The prevalence of Behçet's syndrome in a rural area in Northern Turkey. J Rheumatol 1988; 15: 820-2.
  • 4. Azizlerli G, Köse AA, Sarıca R, Gül A, Tutkun İT, Kulaç M, Tunç R, Urgancıoğlu M, Dişçi R. Prevalence of Behçet's disease in İstanbul, Turkey. Int J Dermatol 2003; 42: 803-6.
  • 5. İdilA, GürlerA, BoyvatA, Çalışkan D, Özdemir O, Işık A, Tunçbilek A, Koçyiğit P, Çalıkoğlu E. The prevalence of Behçet's disease above the age of 10 years. The results of a pilot study conducted at the Park Primary Health Care Center in Ankara, Turkey. Opthalmic Epidemiol 2002; 9: 325-31
  • 6. Yazıcı H, Tüzün Y, Pazarlı H, Yurdakul S, Özyazgan Y, Özdoğan H, Serdaroğlu S, Ersanlı M, Ülkü BY, Müftüoğlu AU. Influence of age of onset and patient's sex on the prevalence and severity of manifestations of Behçet's syndrome.Ann Rheum Dis 1984; 43: 783-9.
  • 7. Zouboulis CC, Vaiopoulos G, Marcomichelakis N, Palimeris G, Markidou I, Thouas B, Kaklamanis P. Onset signs, clinical course, prognosis, treatment and outcome of adult patients with Adamantiades-Behçet's disease in Greece. Clin Exp Rheumatol 2003; 21: 19- 26.
  • 8. Alpsoy E, Dönmez L, Önder M, Günaştı S,Usta A, Karıncaoğlu Y. Clinical course of Behçet's disease in 661 cases: a multicenter study. Br J Dermatol 2007; 157: 901-6.
  • 9. Kontogiannis V, Powell RJ. Behçet's disease. Postgrad Med J 2000; 76: 629-37.
  • 10. Gürler A, Boyvat A, Türsen Ü. Clinical manifestations of Behçet's disease: an analysis of 2147 patients.Yonsei Med J 1997; 38: 423-7.
  • 11. Zouboulis CC, Kötter I, Djawari D, Kirch W, et al. Epidemiological features of Adamantiades-Behçet's disease in Germany and in Europe. Yonsei Med J 1997; 38: 411-22.
  • 12. Saylan T, Mat C, Fresko İ, Melikoğlu M. Behçet's disease in Middle East. Clin Dermatol 1999; 17: 209- 23.
  • 13. Karıncaoğlu Y, Borlu M, Toker SC, Akman A, Önder M, Günaştı S, Usta A, Kandi B, Durusoy C, Seyhan M, Utaş S, Sarıcaoğlu H, Özden MG, Tursen U, Çiçek D, Dönmez L, Alpsoy E. Demographic and clinical properties of juvenile-onset Behçet's disease: A controlled multicenter study. J Am Acad Dermatol 2008; 58: 579-84.
  • 14. Whallett AJ, Thurairajan G, Hamburger J, Palmer RG, Murray PI. Behçet's syndrome. A multidisciplinary approach to clinical care. Q J Med 1999; 92: 727-40.
  • 15. Tursen Ü, Gürler A, Boyvat A. Evaluation of clinical findings according to sex in 2313 Turkish patients with Behçet's disease. Int J Dermatol 2003; 42: 346-51.
  • 16. Bang D, Oh S, Lee KH, Lee ES, Lee S. Influence of sex on patients with Behçet's disease in Korea. J Korean Med Sci 2003; 18: 231-5.
  • 17. Kone-Paut I, Gorchakoff-Molinas A, Weschler B, Touitou I. Paediatric Behçet's disease in France. Ann Rheum Dis 2002; 61: 655-6.
  • 18. Kontogiannis V, Powell RJ. Behçet's disease. Postgrad Med J 2000; 76: 629-37.
  • 19. Jorizzo JL,Abernethy JL,WhiteWL, Mangelsdorf HC, Zouboulis CC, Sarıca R, Gaffney K, Mat C, Yazıcı H, al Ialaan A et al. Mucocutaneous criteria for the diagnosis of Behçet's disease: an analysis of clinicopathological data from multiple international centers. J Am Acad Dermatol 1995; 32: 968-76.
  • 20. Ergun T, Gürbüz O, Doğusoy G, Mat C, Yazıcı H. Histopathologic features of the spontaneous pustular lesions of Behçet's disease. Int J Dermatol 1998; 37: 194-6.
  • 21. Diri E, Mat C, Hamuryudan V, Yurdakul S, Hızlı N, Yazıcı H. Papulopustular skin lesions are seen more frequently in patients with behçet's syndrome who have arthritis: a controlled and masked study. Ann Rheum Dis 2001; 60: 1074-6.
  • 22. Hatemi G, Bahar H, Uysal S, Mat C, Göğüs F, Masatlıoğlu S, Altas K, Yazıcı H. The pustular skin lesions in Behçet's syndrome are not sterile. Ann Rheum Dis 2004; 63: 1450-2.
  • 23. Alpsoy E, Aktekin M, Er H, Durusoy C, Yılmaz E. A randomized, controlled and blinded study of papulopustular lesions in Turkish Behçet's patients. Int J Dermatol 1998; 37: 839-42.
  • 24. Houman MH, Neffati H, Braham A, Harzallah O, Khanfir M, Miled M, Hamzaoui K. Behçet's disease in Tunisia. Demographic, clinical and genetic aspects in 260 patients. Clin Exp Rheumatol 2007; 25: 58-64.
  • 25. Krause I, Molad Y, Mitrani M, Weinberger A. Pathergy reaction in Behçet's disease: lack of correlation with mucocutaneous menifestations and systemic disease expression. 2000; 18: 71-4.
  • 26. Kaklamani VG, Kaklamanis PG. Treatment of Behçet's disease-an update. Semin Arthritis Rheum 2001; 30: 299-312.
  • 27. Özdemir M, Balevi Ş, Deniz F, Mevlitoğlu I. Pathergy reaction in different body areas in Behçet's disease. Clin Exp Dermatol 2006; 32: 85-7.
  • 28. Doğan B, Taşkapan O, Harmanyeri Y. Prevalance of pathergy test positivity in Behçet's disease in Turkey. 2003; 17: 228-9.
  • 29. Dilşen N, Koniçe M, Aral O, Öcal L, İnanç M, Gül A. Comparative study of the skin pathergy test with blunt and sharp needles in Behçet's disease: confirmed specificity but decreased sensitivity with sharp needles. Ann Rheum Dis 1993; 52: 823-5.
  • 30. Fresko I, Yazıcı H, Bayramiçli M, Yurdakul S, Mat C. Effect of surgical cleaning of the skin on the pathergy phenomenon in Behçet's syndrome. Ann Rheum Dis 1993; 52: 619-20.
  • 31. Mat CM, Gökler G, Yurdakul S, Tüzün Y, Hamuryudan V, Kösem V, Özyazgan Y, Yazıcı H. The effect of prick duration on pathergy positivity in Behçet's syndrome. Cerrahpaşa J Med 1996; 27: 94-7.
  • 32. Tugal-Tutkun İ, Onal S, Altan-Yaycıoğlu R, Altunbaş HH, Urgancıoğlu M. Uveitis in Behçet Disease: an analysis of 880 patients. J Opthalmol 2004; 138: 373- 80.
  • 33. Lee SK, Lee J. Behçet's disease- A rheumatologic perspective.Yon Med J 1997; 38: 395-400.
  • 34. Karıncaoğlu Y, Çoşkun BK, Seyhan M, Akı T. Demographical and clinical characteristics of Behçet's disease patients in Malatya and Elazığ. Turkiye Klinikleri J Dermatol 2005; 15: 65-70.
  • 35. Houman MH, Ben Ghorbel I, Khiari Ben Salah I, Lamloum M, Ben Ahmed M, Miled M. Deep vein thrombosis in Behçet's disease. Clin Exp Rheumatol 2001; 19: 48-50.
  • 36. Küçükoğlu RS, Akadağ-Köse A, Kayabalı M, Yazganoğlu KD, Dişçi R, Erzengin D, Azizlerli G. Vascular involvement in Behçet's disease: a retrospective analysis of 2319 cases. Int J Dermatol 2006; 45: 919-21.
  • 37. Düzgün N, Ateş A, Aydıntuğ OT, Demir O, Ölmez U. Characteristics of vascular involvement in Behçet's disease. Scand J Rheumatol 2006; 35: 65-8.
  • 38. Şentürk T, Aydıntuğ O, Kuzu I, Düzgün N, Tokgöz G, Gürler A, Tulunay O. Adhesion molecule expression in eryhtema nodosum-like lesions in Behçet's disease. A histopathological and immunohistochemical study. Rheumatol Int 1998;18: 51-7.
  • 39. Akman A, Yılmaz E, Çiftçioğlu MA, Alpsoy E. Unilateral erythema nodosum-like lesions and superficial thrombophlebitis together with ipsilateral thrombosis of the vena cava femoralis in Behçet's disease. Eur J Dermatol 2006; 16: 703-4.
  • 40. Krause I, Leibovici L, Guedj D, Molad Y, Uziel Y, Weinberger A. Disease patterns of patients with Behçet's disease demonstrated by factor analysis. Clin Exp Dermatol 1999; 17: 347-50.

Behcet's Disease Experience in Aydin: Retrospective Evaluation of 67 Patients

Year 2008, Volume: 9 Issue: 3, 21 - 26, 01.12.2008

Abstract

We aimed to investigate the demographical and clinical features of patients with Behçet's disease
followed up inAdnan Menderes University Medical Faculty, Dermatology Department.
Sixtyseven patients who fullfilled the diagnostic criteria of the International
Study Group for Behçet's Disease were included to the study. Patients records were investigated and analysed by
using SPSS 14 programme.
Patient's age range was between 16-61, mean age was 35.7±10.5 and male/female ratio was 1.48:1.
The mean age at the first symptom of the disease was 27.1±9.3, and mean age of the diagnosis of Behçet's disease
was 32.4±9.6. Oral ulcers (100.0%) and genital ulcers (97.0%) were the most common findings of the disease.
These were followed by papulopustular lesions (72.3%), pathergy positivity (50.8%) erythema nodosum
(38.8%), articular involvement (23.9%), eye involvement (21.5%) and thrombophlebitis (9.1%).
Thrombophlebitis was seen significantly more frequently in male patients than females (p=0.03).
The data of patients with Behçet's disease who were followed up in a Dermatology clinic in
Aydin were presented as a one centered study. Major findings were mucocutaneous ones and none of the patients
had the severe involvement of the Behçet's disease

References

  • 1. Çakır N, Derviş E, Benian O, Pamuk ON, Sönmezateş N, Rahimoğlu R, Tuna S, Çetin T, Sarıkaya Y. Prevalence of Behçet's disease in rural western Turkey: a preliminary report. Clin Exp Rheumatol 2004; 22: 53- 5.
  • 2. Tüzün Y, Yurdakul S, Cem Mat M, Özyazgan Y, Hamuryudan V, Tüzün B, Yazıcı H. Epidemiology of Behçet's syndrome in Turkey. Int J Dermatol 1996; 35: 618-20.
  • 3. Yurdakul S, Günaydın I, Tüzün Y, Tankurt N, Pazarlı H, Özyazgan Y, Yazıcı H.The prevalence of Behçet's syndrome in a rural area in Northern Turkey. J Rheumatol 1988; 15: 820-2.
  • 4. Azizlerli G, Köse AA, Sarıca R, Gül A, Tutkun İT, Kulaç M, Tunç R, Urgancıoğlu M, Dişçi R. Prevalence of Behçet's disease in İstanbul, Turkey. Int J Dermatol 2003; 42: 803-6.
  • 5. İdilA, GürlerA, BoyvatA, Çalışkan D, Özdemir O, Işık A, Tunçbilek A, Koçyiğit P, Çalıkoğlu E. The prevalence of Behçet's disease above the age of 10 years. The results of a pilot study conducted at the Park Primary Health Care Center in Ankara, Turkey. Opthalmic Epidemiol 2002; 9: 325-31
  • 6. Yazıcı H, Tüzün Y, Pazarlı H, Yurdakul S, Özyazgan Y, Özdoğan H, Serdaroğlu S, Ersanlı M, Ülkü BY, Müftüoğlu AU. Influence of age of onset and patient's sex on the prevalence and severity of manifestations of Behçet's syndrome.Ann Rheum Dis 1984; 43: 783-9.
  • 7. Zouboulis CC, Vaiopoulos G, Marcomichelakis N, Palimeris G, Markidou I, Thouas B, Kaklamanis P. Onset signs, clinical course, prognosis, treatment and outcome of adult patients with Adamantiades-Behçet's disease in Greece. Clin Exp Rheumatol 2003; 21: 19- 26.
  • 8. Alpsoy E, Dönmez L, Önder M, Günaştı S,Usta A, Karıncaoğlu Y. Clinical course of Behçet's disease in 661 cases: a multicenter study. Br J Dermatol 2007; 157: 901-6.
  • 9. Kontogiannis V, Powell RJ. Behçet's disease. Postgrad Med J 2000; 76: 629-37.
  • 10. Gürler A, Boyvat A, Türsen Ü. Clinical manifestations of Behçet's disease: an analysis of 2147 patients.Yonsei Med J 1997; 38: 423-7.
  • 11. Zouboulis CC, Kötter I, Djawari D, Kirch W, et al. Epidemiological features of Adamantiades-Behçet's disease in Germany and in Europe. Yonsei Med J 1997; 38: 411-22.
  • 12. Saylan T, Mat C, Fresko İ, Melikoğlu M. Behçet's disease in Middle East. Clin Dermatol 1999; 17: 209- 23.
  • 13. Karıncaoğlu Y, Borlu M, Toker SC, Akman A, Önder M, Günaştı S, Usta A, Kandi B, Durusoy C, Seyhan M, Utaş S, Sarıcaoğlu H, Özden MG, Tursen U, Çiçek D, Dönmez L, Alpsoy E. Demographic and clinical properties of juvenile-onset Behçet's disease: A controlled multicenter study. J Am Acad Dermatol 2008; 58: 579-84.
  • 14. Whallett AJ, Thurairajan G, Hamburger J, Palmer RG, Murray PI. Behçet's syndrome. A multidisciplinary approach to clinical care. Q J Med 1999; 92: 727-40.
  • 15. Tursen Ü, Gürler A, Boyvat A. Evaluation of clinical findings according to sex in 2313 Turkish patients with Behçet's disease. Int J Dermatol 2003; 42: 346-51.
  • 16. Bang D, Oh S, Lee KH, Lee ES, Lee S. Influence of sex on patients with Behçet's disease in Korea. J Korean Med Sci 2003; 18: 231-5.
  • 17. Kone-Paut I, Gorchakoff-Molinas A, Weschler B, Touitou I. Paediatric Behçet's disease in France. Ann Rheum Dis 2002; 61: 655-6.
  • 18. Kontogiannis V, Powell RJ. Behçet's disease. Postgrad Med J 2000; 76: 629-37.
  • 19. Jorizzo JL,Abernethy JL,WhiteWL, Mangelsdorf HC, Zouboulis CC, Sarıca R, Gaffney K, Mat C, Yazıcı H, al Ialaan A et al. Mucocutaneous criteria for the diagnosis of Behçet's disease: an analysis of clinicopathological data from multiple international centers. J Am Acad Dermatol 1995; 32: 968-76.
  • 20. Ergun T, Gürbüz O, Doğusoy G, Mat C, Yazıcı H. Histopathologic features of the spontaneous pustular lesions of Behçet's disease. Int J Dermatol 1998; 37: 194-6.
  • 21. Diri E, Mat C, Hamuryudan V, Yurdakul S, Hızlı N, Yazıcı H. Papulopustular skin lesions are seen more frequently in patients with behçet's syndrome who have arthritis: a controlled and masked study. Ann Rheum Dis 2001; 60: 1074-6.
  • 22. Hatemi G, Bahar H, Uysal S, Mat C, Göğüs F, Masatlıoğlu S, Altas K, Yazıcı H. The pustular skin lesions in Behçet's syndrome are not sterile. Ann Rheum Dis 2004; 63: 1450-2.
  • 23. Alpsoy E, Aktekin M, Er H, Durusoy C, Yılmaz E. A randomized, controlled and blinded study of papulopustular lesions in Turkish Behçet's patients. Int J Dermatol 1998; 37: 839-42.
  • 24. Houman MH, Neffati H, Braham A, Harzallah O, Khanfir M, Miled M, Hamzaoui K. Behçet's disease in Tunisia. Demographic, clinical and genetic aspects in 260 patients. Clin Exp Rheumatol 2007; 25: 58-64.
  • 25. Krause I, Molad Y, Mitrani M, Weinberger A. Pathergy reaction in Behçet's disease: lack of correlation with mucocutaneous menifestations and systemic disease expression. 2000; 18: 71-4.
  • 26. Kaklamani VG, Kaklamanis PG. Treatment of Behçet's disease-an update. Semin Arthritis Rheum 2001; 30: 299-312.
  • 27. Özdemir M, Balevi Ş, Deniz F, Mevlitoğlu I. Pathergy reaction in different body areas in Behçet's disease. Clin Exp Dermatol 2006; 32: 85-7.
  • 28. Doğan B, Taşkapan O, Harmanyeri Y. Prevalance of pathergy test positivity in Behçet's disease in Turkey. 2003; 17: 228-9.
  • 29. Dilşen N, Koniçe M, Aral O, Öcal L, İnanç M, Gül A. Comparative study of the skin pathergy test with blunt and sharp needles in Behçet's disease: confirmed specificity but decreased sensitivity with sharp needles. Ann Rheum Dis 1993; 52: 823-5.
  • 30. Fresko I, Yazıcı H, Bayramiçli M, Yurdakul S, Mat C. Effect of surgical cleaning of the skin on the pathergy phenomenon in Behçet's syndrome. Ann Rheum Dis 1993; 52: 619-20.
  • 31. Mat CM, Gökler G, Yurdakul S, Tüzün Y, Hamuryudan V, Kösem V, Özyazgan Y, Yazıcı H. The effect of prick duration on pathergy positivity in Behçet's syndrome. Cerrahpaşa J Med 1996; 27: 94-7.
  • 32. Tugal-Tutkun İ, Onal S, Altan-Yaycıoğlu R, Altunbaş HH, Urgancıoğlu M. Uveitis in Behçet Disease: an analysis of 880 patients. J Opthalmol 2004; 138: 373- 80.
  • 33. Lee SK, Lee J. Behçet's disease- A rheumatologic perspective.Yon Med J 1997; 38: 395-400.
  • 34. Karıncaoğlu Y, Çoşkun BK, Seyhan M, Akı T. Demographical and clinical characteristics of Behçet's disease patients in Malatya and Elazığ. Turkiye Klinikleri J Dermatol 2005; 15: 65-70.
  • 35. Houman MH, Ben Ghorbel I, Khiari Ben Salah I, Lamloum M, Ben Ahmed M, Miled M. Deep vein thrombosis in Behçet's disease. Clin Exp Rheumatol 2001; 19: 48-50.
  • 36. Küçükoğlu RS, Akadağ-Köse A, Kayabalı M, Yazganoğlu KD, Dişçi R, Erzengin D, Azizlerli G. Vascular involvement in Behçet's disease: a retrospective analysis of 2319 cases. Int J Dermatol 2006; 45: 919-21.
  • 37. Düzgün N, Ateş A, Aydıntuğ OT, Demir O, Ölmez U. Characteristics of vascular involvement in Behçet's disease. Scand J Rheumatol 2006; 35: 65-8.
  • 38. Şentürk T, Aydıntuğ O, Kuzu I, Düzgün N, Tokgöz G, Gürler A, Tulunay O. Adhesion molecule expression in eryhtema nodosum-like lesions in Behçet's disease. A histopathological and immunohistochemical study. Rheumatol Int 1998;18: 51-7.
  • 39. Akman A, Yılmaz E, Çiftçioğlu MA, Alpsoy E. Unilateral erythema nodosum-like lesions and superficial thrombophlebitis together with ipsilateral thrombosis of the vena cava femoralis in Behçet's disease. Eur J Dermatol 2006; 16: 703-4.
  • 40. Krause I, Leibovici L, Guedj D, Molad Y, Uziel Y, Weinberger A. Disease patterns of patients with Behçet's disease demonstrated by factor analysis. Clin Exp Dermatol 1999; 17: 347-50.
There are 40 citations in total.

Details

Other ID JA25YT29SH
Journal Section Research Article
Authors

Meltem Uslu This is me

Göksun Karaman This is me

Ekin Şavk This is me

Neslihan Şendur This is me

Eylem Yılmaz This is me

Publication Date December 1, 2008
Published in Issue Year 2008 Volume: 9 Issue: 3

Cite

EndNote Uslu M, Karaman G, Şavk E, Şendur N, Yılmaz E (December 1, 2008) Behcet’s Disease Experience in Aydin: Retrospective Evaluation of 67 Patients. Meandros Medical And Dental Journal 9 3 21–26.