Lipid Peroxidation and Antioxidant Activity in Normal and Preeclampsic Pregnancies

Year 2009, Volume: 10 Issue: 2, 53 - 58, 01.08.2009

Mehmet Berköz Serap Yalın

Abstract

Serbest radikallerin oluşumu normal fizyolojik bir süreçtir ve bu serbest radikaller lipidler üzerinde lipidperoksidasyonuna yol açmaktadır. Bununla birlikte insan vücut hücreleri bir takım antioksidan savunmasistemleri geliştirmişlerdir. Lipid peroksidasyonu-antioksidan dengesi hayatın her evresinde olduğu gibihamilelik döneminde de hem annenin hem de fetüsün fizyolojik fonksiyonlarını sürdürebilmesi için önemtaşımaktadır. Hamilelik boyunca artan plasental lipoperoksidatif aktivite hem plasentaya hem de fetüse olumsuzetkiler yapmaktadır. Preeklamptik hamileliklerde ise vasküler endotel hücre disfonksiyonuna bağlı olarak lipidperoksidasyonundaki artış bu durumu çok daha dramatik bir hale getirmektedir. Bu yüzden antioksidan savunmasisteminin devreye girip girmemesi durumun seyri açısından oldukça önem taşımaktadır. Son yıllarda yapılançalışmalarda, lipid peroksidasyonundaki yükselmeye karşın antioksidan sisteminin devreye girmediğidurumlarda eksojen vitamin takviyesinin gerekebileceği ve bu müdahalenin hem annenin hem de fetüsün hayatıiçin koruyucu olabileceği belirtilmektedir

Keywords

Lipid peroksidasyonu, antioksidan savunma sistemi, hamilelik, preeklampsi

Lipid Peroxidation and Antioxidant Activity in Normal and Preeclampsic Pregnancies

Abstract

The formation of free radicals is a normal physiological course and free radicals which act on lipids cause to lipid peroxidation. Nevertheless, all human body cells have developed a set of antioxidant defence system. During pregnancy, the balance between lipid peroxidation and antioxidant defence system is also important as all terms of the human life for resuming the basic physiological functions of both mother and her fetus. Increasing on placental lipoperoxidative activity during pregnancy could effect the placenta and fetus unfavorably. In preeclamptic pregnancies, vasculer endothelial cell disfunction could rise the lipid peroxidation more dramatically. Therefore, intervening the antioxidant defence system is highly vital for the prognosis of the condition. According to the recent studies, antioxidant vitamin supplement can be required whether the antioxidant system doesn't step in against to the lipid peroxidation and this treatment could protect the life of mother and her fetus.

Keywords

Lipid peroxidation, antioxidant defence system, pregnancy, preeclampsia

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• Mersin Üniversitesi Eczacılık Fakültesi, Biyokimya
• Anabilim Dalı, MERSİN Telefon Faks
• :0 324 341 30 22 E-Posta
• :[e-mail] Geliş Tarihi Kabul Tarihi :25.09.2008