BENİGN VE MALİGN NEOPLASTİK DERİ LEZYONLARINDA EPİDERMAL LANGERHANS HÜCRELERİ VE DERMAL MAST HÜCRELERİ

Year 2011, Volume: 12 Issue: 2, 11 - 16, 01.08.2011

Canten Tataroğlu Nil Çulhacı Emel Dikicioğlu Çetin Zehra Kesen Hicran Turhan

Abstract

AMAÇ:Langerhans hücreleri ve mast hücreleri kemik iliği kökenli hücreler olup dermis ve epidermisin immunsisteminde kritik rol oynarlar. Biz bu çalışmada benign ve malign skuamoid tümörlerde mast hücre veLangerhans hücrelerinin rolünü değerlendirmeyi amaçladık.GEREÇ veYÖNTEM:Bu araştırmaya 12 seboreik keratoz, 9 aktinik keratoz, 15 keratoakantom ve 33 skuamözhücreli karsinom olgusu alındı. Dermal mast hücreleri ve epidermal peri ve intratümöral Langerhans hücrelerisırasıyla mast hücre triptaz ve CD1a antikorlarıyla boyandı.BULGULAR:Mast hücre sayısı skuamöz hücreli karsinomda seboreik keratoza göre anlamlı olarak yüksekti(p=0.001). Mast hücre sayısı diğer tümör grupları arasında farklılık göstermedi. İntratümöral Langerhanshücreleri seboreik keratozda skuamöz hücreli karsinoma göre önemli oranda artmış saptandı (p=0.026).Peritümöral Langerhans hücreleri ise skuamöz hücreli karsinom (p=0.007, p=0.001) ve keratoakantomda(p=0.001, p=0.001), aktinik keratoz ve seboreik keratoza oranla artmış olarak saptandı.SONUÇ:Sonuç olarak biz çalışmamızda skuamöz hücreli karsinom ve keratoakantomda peritümöralLangerhans hücreleri ve mast hücrelerini sayıca artmış bulduk. İmmün sistemde görevleri bulunan epidermalLangerhans hücreleri ve dermal mast hücrelerinin benign ve malign deri tümörlerinde farklı rolleri olduğunudüşündürmektedir

Keywords

Mast hücreleri, Langerhans hücreleri, deri tümörleri

Epidermal Langerhans Cells and Dermal Mast Cells in Bening and Malignant Neoplastic Skin Lesions

Abstract

PORPOSE: Langerhans cells and mast cells are bone marrow derived cells. They represent a critical role in the immune system in the epidermis and dermis. In the present study, we aimed to evaluate the role of mast cells and Langerhans cells in benign and malignant squamous tumors. MATERIALS and METHODS: This study included 12 patients with seborrheic keratosis, 9 patients with actinic keratosis, 15 patients with keratoacanthoma and 33 patients with squamous cell carcinoma. Dermal mast cells and epidermal peri and intratumoral Langerhans cells were labeled with mast cell tryptase and CD1a antibodies respectively. RESULTS: The number of mast cells were significantly increased in the patients with squamous cell carcinoma in comparison with seborrheic keratosis (p=0.001). However, this parameter did not show significant difference between patients of other groups. The number of intratumoral Langerhans cells in seborrheic keratosis were significantly increased in comparison with squamous cell carcinoma (p=0.026). The peritumoral Langerhans cells were increased in squamous cell carcinoma (p=0.007, p=0.001) and keratoacanthoma (p=0.001, p=0.001) in comparison with actinic keratosis and seborrheic keratosis. CONCLUSION: Our immunohistochemical study has demonstrated that peritumoral Langerhans cells and mast cells are increased in number in keratoacanthoma and squamous cell carcinoma. Both epidermal Langerhans cells and dermal mast cells which have some contributions in the immune system, are different in number in benign and malignant skin tumors.

Keywords

Mast cells, Langerhans cells, skin tumors

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