ANKİLOZAN SPONDİLİT VE İNSAN LÖKOSİT ANTİJENİ-B27 POZİTİFLİĞİNDE SİSTEMİK İMMÜN-İNFLAMASYON İNDEKSİ VE PAN-İMMÜN-İNFLAMASYON DEĞERİNİN PROGNOSTİK ÖNEMİ

Year 2024, Volume: 25 Issue: 3, 244 - 252, 30.09.2024

Adem Keskin , Taner Karakaya , Recai Aci , Ozlem Sezer , Samet Semiz , Ferhat Şirinyıldız , İpek Okutan

https://doi.org/10.69601/meandrosmdj.1542434

Abstract

Amaç: Ankilozan spondilit (AS) hem otoimmün hem de otoinflamatuar bir hastalık olarak tanımlanır. Kronik inflamatuar hastalıklarda tanı amaçlı yaygın olarak kullanılan insan lökosit antijeni B27 (HLA-B27), AS dahil aksiyel spondiloartritin temel laboratuvar parametresidir. Tam kan sayımı parametrelerinin formüle edilmesiyle elde edilen sistemik immün-inflamasyon indeksi (SII) ve pan-immün-inflamasyon değeri (PIV), sistemik inflamasyonu ve lokal immün yanıtı yansıtan ve hastalıklarda prognozu öngören umut verici biyobelirteçlerdir. Bu çalışmanın amacı, AS hastalarında HLA-B27 pozitifliğini öngörmede SII ve PIV biyobelirteçlerinin duyarlılığını ve özgüllüğünü araştırmaktır.
Gereç ve Yöntemler: Çalışmaya HLA-B27 testleri pozitif olan 68 hasta (AS grubu) ve HLA-B27 testleri negatif olan 102 hasta (kontrol grubu) dahil edildi.
Bulgular: AS grubunda lenfosit ve ortalama trombosit hacmi değerleri kontrol grubuna göre düşük bulunurken, diğer tam kan sayımı parametreleri, eritrosit sedimantasyon oranı (ESR) ve C-reaktif protein (CRP) daha yüksek bulundu. AS grubunun SII ve PIV değerleri CRP ve ESR düzeyleri ile pozitif korelasyon gösterirken, kontrol grubunda korelasyon göstermedi. HLA-B27 pozitifliğini öngörmede PIV için duyarlılık %83,80, özgüllük %84,30 bulunurken, SII için duyarlılık %83,80, özgüllük %86,30 bulundu.
Sonuç: Kolayca ve hızla erişilebilen biyobelirteçler SII ve PIV, AS hastalarında HLA-B27 pozitifliğini tahmin etmek için potansiyel olarak kullanılabilir.

Keywords

Ankilozan Spondilit, SII, PIV, İnsan lökosit antijeni-b27.

SYSTEMIC IMMUNE INFLAMMATION INDEX AND PAN-IMMUNE INFLAMMATION VALUE IN PREDICTING HUMAN LEUKOCYTE ANTIGEN-B27 POSITIVITY: A STUDY ON ANKYLOSING SPONDYLITIS PATIENTS

Abstract

Objective: Ankylosing spondylitis (AS) is defined as both an auto-immune and autoinflammatory illness. Human leukocyte antigen B27 (HLA-B27), which is extensively employed in the diagnosis of chronic inflammatory diseases, is the basic laboratory parameter of axial spondylarthritis including AS. Systemic immune-inflammation index (SII) and pan-immune-inflammation value (PIV), obtained by formulating complete blood count parameters, are promising biomarkers that reflect systemic inflammation and local immune response and predict prognosis in diseases. The aim of this study was to investigate the sensitivity and specificity of SII and PIV biomarkers in predicting HLA-B27 positivity in AS patients.
Materials and Methods: The research included 68 individuals with HLA-B27 tests (+) (AS group) and 102 patients with HLA-B27 tests (-) (control group).
Results: In the AS group, lymphocyte and mean platelet volume values were determined to be lower than in the control group, while other complete blood count parameters, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), were found to be higher. While the SII and PIV values of the AS group determined a positive relation with CRP and ESR levels, they did not show a correlation in the control group. While the sensitivity for PIV in predicting HLA-B27 positivity was found to be 83.80% and the specificity was found to be 84.30%, for SII the sensitivity was found to be 83.80% and the specificity was found to be 86.30%.
Conclusion: Easily and rapidly accessible biomarkers SII and PIV can potentially be used to predict HLA-B27 positivity in AS patients.

Keywords

PIV, Ankylosing Spondylitis, SII, Human leukocyte antigen-b27

Ethical Statement

The ethics committee decision for the research was taken at the Samsun University Non-Interventional Clinical Ethics Committee meeting held on February 28, 2024. (Protocol code: GOKAEK 2024/5/5).

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