Relationship between Newly Diagnosed Hypertensive Patients’ DippingStatus and Mean Neutrophil Volume

Year 2023, Volume: 24 Issue: 4, 292 - 297, 30.12.2023

Muhammet Salih Ateş , Muhammed Ulvi Yalçın Abdullah Tunçez , Kenan Demir Nazif Aygül

Abstract

Objective: Little is known about the pathogenesis of essential hypertension (HT) despite the research conducted in this field. However, similar to other chronic diseases, an association has been shown between HT and inflammation. Thus, this study aimedto explore the association between an indicator of inflammatory response and mean neutrophil volume (MNV) in newly diagnosedhypertensive patients.
Materials and Methods: The medical records of patients newly diagnosed with HT were retrospectively reviewed. The control groupcomprised healthy persons with normal ambulatory blood pressure records. In accordance with their immersion status, newlydiagnosed hypertensive patients were divided into two groups.
Results: This study included 222 patients: One hundred and forty four patients had HT, and one hundred and eighty-eight werenormotensives. HT patients had significantly higher MNV than normotensive patients [144.1 (range: 136.1-152.1 vs.) 140.3 (range: 135.1-145.5), p=0.001], respectively. There were 51 patients with dipper HT and 53 patients with non-dipper HT in the hypertensivegroup. MNV was significantly higher in the non-dipper HT group [145.7 (range: 138.1-153.46) vs. 142.3 (range: 134.3-150.3), p=0.022], respectively. Multivariate regression analysis demonstrated that MNV [95% confidence interval (CI): 1,006-1,122, p=0.032] andpulse wave velocity (95% CI: 1,203-2,655, p=0.004) were independently correlated with the non-dipping status in newly diagnosedhypertensive patients.
Conclusion: Patients with newly diagnosed HT had higher MNV. In addition, increased MNV measurements were associatedwithnon-dipper HT.

Keywords

Hypertension , mean neutrophil volume , pulse wave velocity , non-dipper hypertension , MNV

References

• 1. Sliwa K, Stewart S, Gersh BJ. Hypertension: a global perspective. Circulation 2011; 123: 2892-6.
• 2. Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, BurnierM, et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension. Eur Heart J 2018; 39: 3021-104.
• 3. Skeete J, Connell K, Ordunez P, DiPette DJ. The American Collegeof Cardiology/American Heart Association 2017 hypertension guideline: Implications for incorporation in Latin America, the Caribbean, and other resource-limited settings. J Clin Hypertens (Greenwich) 2018; 20: 1342-9.
• 4. Shimamoto K. [Guideline for the managements of hypertension -blood pressure control for the elderly hypertension]. Nihon Ronen Igakkai Zasshi 2011; 48: 648-50.
• 5. Virdis A, Dell’Agnello U, Taddei S. Impact of inflammation on vascular disease in hypertension. Maturitas 2014; 78: 179-83.
• 6. Bermudez EA, Rifai N, Buring J, Manson JE, Ridker PM. Interrelationships among circulating interleukin-6, C-reactive protein, and traditional cardiovascular risk factors in women. Arterioscler Thromb Vasc Biol 2002; 22: 1668-73.
• 7. Shankar A, Klein BE, Klein R. Relationship between white blood cell count and incident hypertension. Am J Hypertens 2004; 17: 233-9.
• 8. Coppo M, Bandinelli M, Berni A, Galastri S, Abbate R, Poggesi L, et al. Ang II Upregulation of the T-lymphocyte renin-angiotensin system is amplified by low-grade inflammation in human hypertension. Am J Hypertens 2011; 24: 716-23.
• 9. Virdis A, Schiffrin EL. Vascular inflammation: a role in vascular disease in hypertension? Curr Opin Nephrol Hypertens 2003; 12: 181-7.
• 10. Bagdasaryan R, Zhou Z, Tierno B, Rosenman D, Xu D. Neutrophil VCS parameters are superior indicators for acute infection. Lab Hematol 2007; 13: 12-6.
• 11. De Smet D, Van Moer G, Martens GA, Nanos N, Smet L, Jochmans K, et al. Use of the Cell-Dyn Sapphire hematology analyzer for automated counting of blood cells in body fluids. Am J Clin Pathol 2010; 133: 291-9.
• 12. Bhargava M, Saluja S, Sindhuri U, Saraf A, Sharma P. Elevated mean neutrophil volume+CRP is a highly sensitive and specific predictor of neonatal sepsis. Int J Lab Hematol 2014; 36: e11-4.
• 13. van Hout GP, van Solinge WW, Gijsberts CM, Teuben MP, Leliefeld PH, Heeres M, et al. Elevated mean neutrophil volume represents altered neutrophil composition and reflects damage after myocardial infarction. Basic Res Cardiol 2015; 110: 58.
• 14. Celik IH, Demirel G, Aksoy HT, Erdeve O, Tuncer E, Biyikli Z, et al. Automated determination of neutrophil VCS parameters in diagnosis and treatment efficacy of neonatal sepsis. Pediatr Res 2012; 71: 121-5
• 15. Lee AJ, Kim SG. Mean cell volumes of neutrophils and monocytes are promising markers of sepsis in elderly patients. Blood Res 2013; 48: 193-7.
• 16. Zhu Y, Cao X, Zhang K, Xie W, Xu D, Zhong C. Delta mean neutrophil volume (ΔMNV) is comparable to procalcitonin for predictingpostsurgical bacterial infection. J Clin Lab Anal 2014; 28: 301-5.
• 17. Suresh PK, Minal J, Rao PS, Ballal K, Sridevi HB, Padyana M. VolumeConductivity and Scatter Parameters as an Indicator of AcuteBacterial Infections by the Automated Haematology Analyser. JClinDiagn Res 2016; 10: EC01-3.
• 18. Mardi D, Fwity B, Lobmann R, Ambrosch A. Mean cell volumeof neutrophils and monocytes compared with C-reactive protein, interleukin-6 and white blood cell count for prediction of sepsisand nonsystemic bacterial infections. Int J Lab Hematol 2010; 32: 410-8.
• 19. Schunkert H. Management der arteriellen Hypertonie : ESC/ESHLeitlinien 2018 [Management of arterial hypertension : ESC/ESHguidelines 2018]. Herz 2018; 43: 695-700.
• 20. Wassertheurer S, Kropf J, Weber T, van der Giet M, BaulmannJ, Ammer M, et al. A new oscillometric method for pulsewaveanalysis: comparison with a common tonometric method. JHumHypertens 2010; 24: 498-504.
• 21. Araos P, Figueroa S, Amador CA. The Role of NeutrophilsinHypertension. Int J Mol Sci 2020; 21: 8536.
• 22. Buyukterzi Z GK, Erdem S. Akut Koroner Sendromlu HastalardaOrtalama Nötrofil Hacmi Artar Kocaeli Medical Journal 2019; 8: 74-80.
• 23. Kim BK, Lim YH, Lee HT, Lee JU, Kim KS, KimSG, et al. NonDipper Pattern is a Determinant of the Inappropriateness of Left Ventricular Mass in Essential Hypertensive Patients. KoreanCircJ2011; 41: 191-7.
• 24. de la Sierra A, Redon J, Banegas JR, Segura J, Parati G, Gorostidi M, et al. Prevalence and factors associated with circadianbloodpressure patterns in hypertensive patients. Hypertension 2009; 53: 466-72.
• 25. Cuspidi C, Macca G, Sampieri L, Fusi V, Severgnini B, MichevI, et al. Target organ damage and non-dipping pattern definedbytwo sessions of ambulatory blood pressure monitoring in recentlydiagnosed essential hypertensive patients. J Hypertens 2001; 19: 1539-45.