Protective Effect of Vitamin B5 (Dexpanthenol) on Nephropathy in Streptozotocin Diabetic Rats

Year 2021, Volume: 22 Issue: 1, 53 - 56, 30.04.2021

Nazlı Gülriz Çeri , Kanat Gülle , Mehmet Araslı , Meryem Akpolat Ferah , Buket Demirci

https://doi.org/10.4274/meandros.galenos.2021.65002

Cited By: 1

Abstract

Objective: This study aimed to evaluate the effects of vitamin B5 [dexpanthenol, DEX] treatment on the kidney in a streptozotocin (STZ) diabetes animal model.
Materials and Methods: Twenty-four Wistar rats were randomised in one of the four groups: Group 1 served as control, and group 2 was administered high-dose DEX (300 mg/kg/day) as a safety group. Diabetes was induced by intraperitoneal injection of a single dose of STZ (50 mg/kg) in groups 3 and 4. In group 4, DEX was administered as well. All groups were followed up for 6 weeks. Histopathological analyses were performed on renal tissue using periodic acid-Schiff and Hematoxylin Eosin stains.
Results: Microscopic evaluation of the kidney revealed that the rats demonstrated kidney damage 6 weeks after STZ administration. However, high-dose and longterm DEX administration alone did not damage renal tissue; moreover, kidney damage was prevented if DEX was administered in the early phase of diabetes.
Conclusion: DEX could be a safe and cost-effective vitamin for the prevention of diabetes complications.

Keywords

Cytokines , panthenol , pantothenic acid , pantothenol , streptozotocin

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